Ito TY, Trant AS, Polan ML. A double-blind placebo-controlled study of ArginMax, a nutritional supplement for enhancement of female sexual function. J Sex Marital Ther 2001; 27(5):541-9.
Seventy-seven women (aged 24-71 years) with sexual dysfunction were randomly assigned to daily supplementation with Arginmax or placebo for four weeks. Physical examination, blood pressure and Female Sexual Function Index (FSFI) were used at baseline and at four weeks. Researchers observed an improvement in sexual desire in women in the ArginMax group. Large scale studies are needed to verify these results.
Ito TY, Polan ML, Whipple B, Trant AS. The enhancement of female sexual function with ArginMax, a nutritional supplement, among women differing in menopausal status. J Sex Marital Ther. 2006 Oct-Dec;32(5):369-78.
One hundred eight (108) women, ages 22-73 years, reporting lack of sexual desire, were randomized to receive ArginMax or placebo. The women self-reported as 59 premenopausal (PRE); 20 perimenopausal (PERI), and 29 postmenopausal (POST). After 4 weeks, PRE women on ArginMax reported significant improvement in level of sexual desire (72%; p = 0.03) and satisfaction with overall sex life (68%; p = 0.007), compared with placebo group, according to the Female Sexual Function Index (FSFI; Kaplan et al., 1999) scales. Frequency of sexual desire (60%; p = 0.05) and frequency of intercourse (56% p = 0.01) also increased among the PRE women. Among PERI women, primary improvements were reported for frequency of intercourse (86%; p = 0.002), satisfaction with sexual relationship (79%; p = 0.03), and vaginal dryness (64%; p = 0.03) compared with placebo group. POST women primarily showed an increase in level of sexual desire, with 51% showing improvement, compared with only 8% in the placebo group (p = 0.008).
Additional studies are needed to confirm these observations.