Common: Dizziness, vertigo, nausea, vomiting, skin irritation, esophageal burning, burning of the gums, systemic burning, oral leukoplakia.
Rare: hypersensitivity reaction, angioedema.
(11) (10) (14)
An 87-year-old Caucasian man with a history of basal cell carcinomas self-treated a new basal cell carcinoma over his left nasal ala with a “black salve” (a combination of zinc chloride and bloodroot). This resulted in complete loss of the nasal ala (24).
Two men, one with unremarkable medical history and the other with metastatic colon cancer used bloodroot salves for treating their skin lesions. The lesions in both men grew worse after application of the salve requiring hospitalization (26).
A 63-year-old man diagnosed with basal cell carcinoma preferred to self-treat the lesion with the black salve product containing 300 mg of bloodroot, galangal, red clover, and sheep sorrel. After a 4-month delay with no improvement, the patient consented to Mohs micrographic surgery. But a few months later, he was diagnosed with colon cancer and elected to self-treat with an oral black salve product and subsequently died (28).