Knott A, et al. Natural Arctium lappa fruit extract improves the clinical signs of aging skin. J Cosmet Dermatol. 2008 Dec;7(4):281-9.
The goal of this study was to identify an active ingredient with anti-inflammatory and dermal matrix stimulating activity for use in a clinical trial studying its effect on the clinical signs of aging skin. In vitro assays with human dermal fibroblasts and monocyte-derived dendritic cells treated with pure arctiin displayed a stimulation in collagen synthesis and decrease in the proinflammatory factors IL-6 and TNF-a, compared to control cells. Topical in vivo application of a formulation containing A. lappa extract for 12 weeks (n=6), found that it significantly increased procollagen synthesis (p=0.01), and hyaluron synthase-2 expression (p<0.05), and improved hyaluron levels, compared to vehicle-treated areas. Treatment with an A. lappa containing formulation for 4 weeks was also found to significantly reduced “crow's feet” wrinkle volume around the eyes (p=0.05; n=38), as compared to treatment with the vehicle.
Wang HY, et al. Clinical observation on treatment of diabetic nephropathy with compound Fructus arctii mixture. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Jul;24(7):589-92.
This controlled clinical trial investigated the effect of a fructus arctii mixture (FAM) (Fructus arctii and astragalus root) in treating patients with diabetic neuropathy. In this study, 31 patients were given FAM and a group of 23 patients receiving Losartan served as the control group. Both groups of patients received FAM for 3 months. During the study, clinical symptoms, blood glucose, lipid metabolism, and urinary albumin were monitored. Study results indicated that patients who received FAM had significantly improved clinical symptoms, urinary protein and albumin, and lipid metabolism (p<0.05), whereas patients in the control group only experienced a significant improvement in urinary albumin level (p<0.05). The authors concluded that FAM was effective in reducing urinary albumin and 24 hour urinary protein, and it also improved post-prandial blood glucose and lipid metabolism.