Glyconutrients refer to eight plant monosaccharides: galactose, glucose, arabinose, glucosamine, mannose, xylose, rhamnose, and fucose. Related products are mostly marketed by a company called Mannatech under the brand name Ambrotose. Proponents claim that these monosaccharides are essential for the body because they are building blocks of glycoproteins which are used for cell-to-cell communication. They also suggest that modern diet is deficient in monosaccharides and that supplementation can restore cellular health and support the immune system (1). However, strong scientific evidence to support these claims is lacking.
Glyconutrients are also promoted aggressively to cancer patients through network marketing approach but their benefit is unclear.
- Antitumor properties
- Health maintenance
Commercial products may contain a combination of the following ingredients:
Grape pomace extract
Green tea extract
Australia Bush Plum
Aloe vera gel extract
Wakame (Undaria pinnatifida)
Mechanism of Action
Although sugars such as glucose are essential for normal functioning of the body, true deficiencies are rare except in malnourished patients. Humans can convert saccharides into different forms according to the body's needs. More complex polysaccharides, such as beta-glucan, have been studied for their immunomodulating effects, but it is unclear if the marketed products contain substantial amounts of such polysaccharides. Even though some of the constituents have been investigated for their anticancer effects, none of them have been shown to be effective for cancer treatment. In a trial sponsored by Mannatech, Ambrotose was shown to enhance brain wave activities when compared to placebo. However, the clinical implication remains to be determined (2).
Mannatech and its founder have been charged by the Texas Attorney General for deceptive trade practices that exaggerated the products' health benefits. (3)
There are no known side effects from using Ambrotose.
Dosage (Inside MSKCC Only)
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