Mangosteen is a plant native to Southeast Asia. The fruits are used in traditional medicine to treat skin infections, wounds, and diarrhea.
Recent studies have revealed that xanthones from the fruit hulls exhibit antibacterial (3), antifungal (4), and anti-inflammatory (5), cytototoxic (12) , aromatase-inhibitory (14) and anticancer (17) (18) properties and afford protection against doxorubicin-induced neurotoxicity (19).
Alpha-mangostin, a xanthone, inhibited growth of leukemia HL60 cells (1) (6), reduced the synthesis of prostaglandins (5), and prevented oxidative damage of LDL (7) in vitro. It was also shown to have renoprotective effects against cisplatin-induced nephrotoxicity (16). There is preliminary evidence that alpha- and gamma-mangostins act as histamine and serotonin receptor blockers (8), and inhibit HIV-1 protease (9). Garcinone E, another xanthone, exerts cytotoxic effects against hepatocellular carcinoma cells (10). Extract from the pericarp of mangosteen has antioxidant (13), antiproliferative and apoptotic effects (11).
Small studies in humans suggest its benefits as an adjunct for periodontal treatment (20) and for control of halitosis (21).
Mangosteen products may interfere with certain chemotherapeutic drugs.
Diabetic patients should use mangosteen juice with caution due to the sugar content.