MGN-3 is an arabinoxylan from rice bran made using enzymes from mycelia of shiitake, kawaratake and suehirotake mushrooms. The bioactive constituents are thought to be polysaccharides, which modulate the levels of TNF-alpha and IFN-gamma secretion, and augment natural killer (NK) cell function(3). In rat models, MGN-3 exerted protective effects against D-galactosamine induced liver injury by reducing the expression of interleukin (IL-18) (13); it also protected against hepatitis induced by D-galactosamine by suppressing the inhibition of NF-κB, JNK phosphorylation and CD14 expression (14).
MGN-3 displayed synergistic effects with paclitaxel by causing DNA damage, enhancing apoptosis, and by inhibiting cell proliferation in murine breast cancer cells (10). In another study, MGN-3 exerted antioxidative activity and protected against radiation-induced loss of body and organ weight in mice (11).
MGN-3 has also been shown to affect an increase in natural killer cell activity, in the number of myeloid dendritic cells in peripheral blood, and the concentrations of T helper cell type 1-related cytokines, in a study of myeloma patients (12).