Health Care Professional Information
Phytolacca americana, Phytolacca decandra
Poke Root, pocan, red plant
Derived from various parts of the plant, including root, leaf, and berry. Patients use this herb to treat rheumatoid arthritis, infections, and cancer (as part of the Hoxsey herbal tonic).
Pokeweed has not been studied extensively.
Few in vitro studies indicate that it has antioxidant and acetylcholinesterase inhibition properties (5). Pokeweed antiviral protein (PAP), an N-glycosidase ribosomal-inactivating protein isolated from the plant, demonstrated antiviral effects against encephalitis infection (6).
Pokeweed causes significant toxicity following oral or topical administration.
- Cancer treatment
- Fungal infections
- Induce vomiting
- Rheumatoid arthritis
- Alkaloids: Betanidine, betanine, phytolaccine, prebetanine
- Lectins: Pokeweed mitogen glycoproteins (Pa1-Pa5)
- Saponins: Phytolaccosides (A1, D2, and O), jaligonic acid, phytolaccagenic acid, aesculentic acid
- Other: Isoamericanin A, pokeweed antiviral protein (PAP), alpha-spinasterol, histamine, GABA
Mechanism of Action
Pokeweed mitogens and glycosidic saponins are known toxins that possess mitogenic and irritant properties (1). Pokeweed antiviral protein (PAP) shows broad antiviral activity in vitro. PAP inhibits replication of herpes simplex, influenza and poliovirus, possibly via inactivation of eukaryotic ribosomes (2). Saponin extracts from pokeweed, chiefly phytolaccagenin, exhibit antiinflammatory activity as demonstrated by carrageenan rat paw edema tests. Pokeweed's histamine and GABA content may have hypotensive effects. PAFP-s, an antifungal peptide extract from pokeweed, displays fungistatic effects against a variety of species in vitro (3).
Significant toxicity results from oral and topical administration of pokeweed.
Reported: Nausea, vomiting, stomach cramps, diarrhea, weakness, hematemesis, hypotension, tachycardia.
Toxicity: Prolonged vomiting, bloody diarrhea, dyspnea, muscle spasms, convulsions, death.
Literature Summary and Critique
No study supports the use of pokeweed for any proposed claim.
How It Works
Bottom Line: Because pokeweed has toxic effects, it should not be used to treat cancer, infections, inflammation, or any other medical condition.
Pokeweed products are extracts from all parts of the plant: leaves, root, and berries. Pokeweed contains chemicals that are known toxins, but several of its other components have shown biological activity in laboratory experiments. For example, pokeweed antiviral protein (PAP) is able to stop replication of viruses such as herpes simplex, influenza and poliovirus in the test tube, while pokeweed anti-fungal protein (PAFP) does the same to fungi. Certain saponins from pokeweed also reduce inflammation in rats. None of these effects have been seen in the human body.
- To treat cancer
There are no data to back this claim.
- To treat fungal infections
Pokeweed extracts stop fungal growth in the test tube, but human trials have not been conducted.
- To induce vomiting
Vomiting is a reported side effect of pokeweed.
- To treat infections
Pokeweed extracts stop growth of certain viruses in the test tube. Human data are lacking.
- To reduce inflammation in conditions such as mastitis and rheumatoid arthritis
Although pokeweed extracts reduce inflammation in one experiment in rats, clinical trials are lacking.
- To treat tonsillitis
There are no data to support this claim.
- Significant toxicity results from taking pokeweed by mouth or applying topically.
- Nausea and vomiting
- Stomach cramps
- Vomiting blood
- Low blood pressure
- Tachycardia (fast heart rate)
- Toxicity from high doses or prolonged use of pokeweed can cause protracted vomiting, bloody diarrhea, dyspnea (difficulty breathing), muscle spasms, convulsions, and death.
Last updated: August 9, 2013