Pomegranate is a small fruit-bearing tree native to Asia but is cultivated in many parts of the world including the United States. The fruit juice extracted from the arils of the seeds is used in drinks and as a dietary supplement. Several studies have shown that pomegranate has antioxidant and antiatherosclerotic properties attributed to the presence of multiple polyphenols such as tannins, flavonols, anthocyanins and ellagic acid (1) (2).
Consumption of pomegranate juice was found to benefit patients with carotid artery stenosis (6), in those with hypertension (7), hyperlipidemia (21), mild to moderate erectile dysfunction (19), and in patients with coronary heart disease (CHD) (8), but had no effect in patients with chronic obstructive pulmonary disease (COPD) (9).
In a study of postmenopausal women, intake of pomegranate seed oil did not reduce hot flashes (22).
Pomegranate juice has been shown to suppress inflammatory cell signaling (1), inhibit prostate tumor growth and lower serum PSA levels (3) (4), and also inhibit aromatase activity, endogenous estrogen biosynthesis and breast cancer cell proliferation (5) in vitro.
A pomegranate seed extract alleviated ciplatin-induced hepatotoxicity in animal studies (23).
Pomegranate juice was reported to slow the rate of increase of PSA in men with high PSA levels, but data are conflicting (2) (24).