Hwang YC, et al. The effects of Acanthopanax senticosus extract on bone turnover and bone mineral density in Korean postmenopausal women. J Bone Miner Metab. 2009;27(5):584-90.
This randomized, open-label, controlled study enrolled 81 post-menopausal Korean women (age<65 years) with ostopenia or osteoporosis. Subjects were randomly assigned to a control (n=40) or treatment group (n=41). Both groups received 500 mg/day calcium and the treatment group also received Siberian ginseng extract. After 6 months the treatment group exhibited a significant change in plasma levels of the bone turnover markers, serium osteocalcin (p=0.041) and CTx, (C terminal telopeptide of type 1 collagen, [p<0.0001]), compared with the control group. However, no significant changes in bone density were observed, possibly due to the short treatment duration.. Siberian ginseng extract was well-tolerated and demonstrated a safety profile comparable to the control group. The authors concluded that Siberian ginseng extract is safe and may beneficially affect bone remodeling in Korean post-menopausal women.
Lee YJ, Chung HY, Kwak HK, Yoon S. The effects of A. senticosus supplementation on serum lipid profiles, biomarkers of oxidative stress, and lymphocyte DNA damage in postmenopausal women. Biochem Biophys Res Commun. Oct 10 2008;375(1):44-8.
To determine the effects of Siberian ginseng supplementation on blood lipid levels and oxidative stress, 40 postmenopausal women were randomly divided into either a control group receiving calcium (500 mg/day) or an experimental group receiving both calcium and A. senticosus capsules (500 mg tid). After 6 months, blood lipid profiles, oxidative stress, and lymphocytic DNA damage was assessed along with hepatoxicity. Serum LDL cholesterol, LDL/HDL ratio, lymphocytic DNA damage, and oxidative stress was significantly reduced in the treatment group while the control group did not experience any changes. Furthermore, no side effects were noted during this study. Future studies are required to determine if A. senticosus supplementation produces long term benefits in other study populations.