Health Care Professional Information
Stillingia treculeana, queen’s root, queen’s delight, yaw root
Derived from the root of the plant, this supplement is used to treat syphilis, bronchitis, constipation, hemorrhoids, skin conditions, and is an ingredient in the Hoxsey herbal therapy, used as a cancer treatment.
Stillingia contains diterpene esters that cause mucosal irritation and skin eruptions. Other reported toxicities include vertigo, diarrhea, nausea, vomiting, muscle ache, pruritus, cough, fatigue, and sweating. No clinical data support the use of this supplement for any proposed claim.
Significant toxicity can occur following administration (1).
- Cancer treatment
- Chest congestion
- Skin abscesses
- Terpenoids: Stillingia factors S1-S8
- Diterpene esters: Phorbol, ingenane, daphnane
- Volatile oils
- Other: Sylvacrol, resinic acid, stillingine, tannin, hydrocyanic acid (leaf and stem)
Mechanism of Action
Stillingia has not been evaluated for any proposed claim. It contains diterpene esters, toxic irritants that can cause swelling and inflammation of the skin (1). In vitro research suggests that diterpene esters may have antitumor activity (2), but this has not been confirmed with stillingia root.
The diterpene esters in stillingia are irritants to the skin and mucous membranes (1).
Toxicity: Vertigo, burning sensation on mucous membranes, diarrhea, nausea, vomiting, muscle ache, pruritus, skin eruptions, cough, fatigue, sweating (1).
How It Works
Bottom Line: There is no evidence to support use of Stillingia to treat cancer, infections, or other medical conditions.
Stillingia is a root extract. It is known to contain chemicals called diterpene esters, toxic irritants that can cause swelling and inflammation of the skin. One laboratory experiment suggested that diterpene esters can halt the growth of cancer cells, but this has not been confirmed with stillingia root.
There is no scientific evidence to support any of the uses below:
- To treat bronchitis and relieve chest congestion
- To treat cancer as part of the Hoxsey Herbal Therapy
- To relieve constipation'
- To treat hemorrhoids
- To treat laryngitis
- To treat skin abscesses
- To treat muscle spasms
- To treat syphilis
- Stillingia contains chemicals called diterpene esters, which are known to irritate skin and mucous membranes. Major toxicities can occur when this herb is taken by mouth.
- Burning sensation on mucous membranes
- Muscle aches
- Pruritus (itching of the skin)
- Skin eruptions
- Stillingia root is one of the ingredients in the Hoxsey Herbal Therapy, which is promoted for treating cancer but has never been proven to be effective.
Last updated: February 18, 2014