Hypertension, anxiety, nervousness, nausea, dizziness, tachycardia, palpitations, insomnia, urinary frequency, diarrhea, manic symptoms (1) (6) (15).
Fatalities following accidental yohimbine overdose: Medical examiners attributed 2 unrelated fatalities to accidental acute yohimbine intoxication, due to substantial yohimbine blood concentrations (7,400 and 5,400 ng/mL) and in the absence of other significant positive findings for both cases (23).
Acute neurotoxic effects: Malaise, vomiting, loss of consciousness, and repeated seizures in a 39-year-old body builder following ingestion of yohimbine 5g. Glasgow Coma Score indicated the need for orotracheal intubation. Symptoms subsided 12 h posttreatment with furosemide, labetalol, clonidine, and urapidil as well as gastrointestinal decontamination (24).
Erythrodermic skin eruption, progressive renal failure, and lupus-like syndrome: In a 42-year-old black man following treatment with yohimbine. Patient was admitted and received aggressive hydration, Eucerin cream with 1% hydrocortisone cream for the entire body and betamethasone valerate 0.1 % cream for hands. Patient was discharged after 2 weeks with symptom resolution, although he was readmitted 4 months later for additional clinical presentations (25).
Severe priapism: In a 42-year-old man with complex medical history after ingestion of yohimbe extract. Treatment involved insertion of a proximal cavernosal spongiosum shunt (26).