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Kombucha

How It Works

Bottom Line: Kombucha tea has not been shown to treat cancer or AIDS in humans. The process of fermenting Kombucha tea encourages contamination and serious adverse effects have been reported.
Kombucha is a symbiotic culture of yeasts and bacteria that grows inside a semi-permeable membrane. Kombucha tea is prepared by fermenting sweetened black tea with Kombucha for seven to ten days. Kombucha tea, a slightly carbonated and acidic drink, has been used to treat a wide variety of symptoms and diseases. Kombucha tea has high levels of caffeine, sugar and B vitamins which may account for some of its purported benefits. Kombucha has been shown to have wide antibiotic and antioxidant effects in animals; however few benefits have been shown in humans. Allergic reaction and severe adverse reactions due to contamination have been reported.

Purported Uses

  • To treat atherosclerosis (the formation of plaque on the arteries)
    No scientific evidence supports this use in humans.
  • To treat cancer
    Animal studies have shown Kombucha to have antioxidant effects; however no studies support this use in humans.
  • To treat diabetes
    No scientific evidence supports this use in humans.
  • To treat AIDS
    No scientific evidence supports this use in humans.
  • To lower blood pressure
    No scientific evidence supports this use in humans. 
  • To stimulate the immune system
    Animal studies have shown Kombucha to have immune stimulating activity; however there is no evidence to support this use in humans.

  • Research Evidence

    No clinical studies of Kombucha in humans have been found in published literature.

    Warnings

    • This product is regulated by the F.D.A. as a dietary supplement. Unlike approved drugs, supplements are not required to be manufactured under specific standardized conditions. This product may not contain the labeled amount or may be contaminated. In addition, it may not have been tested for safety or effectiveness.
    • Growing Kombucha in unsanitary conditions has lead to contamination.
    • Lead poisoning has been associated with Kombucha tea brewed in a glazed ceramic pot.

    Do Not Take If

    If your immune system is suppressed, you should avoid Kombucha beverages produced in an uncontrolled environment.

    Side Effects

  • Stomach problems
  • Yeast infections
  • Anthrax contamination
  • Allergic reaction
  • Jaundice
  • Head and neck pain
  • Impairment of liver function

  • Common Name

    Champagne of Life, Manchurian Fungus, Manchurian mushroom, Tea Fungus, Kargasok Tea, Haipao, Fungus Japanicus, Combucha, Kwassan, Spumonto, T'Chai from the Sea, Tschambucco

    Clinical Summary

    Prepared by fermenting sweetened black tea with a symbiotic culture of yeasts and bacteria, Kombucha tea has been used to treat a wide variety of symptoms as well as certain diseases such as cancer, AIDS and diabetes (3). The high caffeine and sugar content of the tea may account for increased energy some users have reported following consumption of the product (4). Animal studies have shown potent antioxidant, immunostimulating (5), and hepato-protective (6) effects with limited toxicity (7), however clinical studies in humans are lacking (8). Because of the method of preparation, Kombucha can easily become contaminated. Allergic reactions, jaundice, serious illness and occasionally death have been associated with the consumption of home-grown Kombucha tea (9) (10) (11). Kombucha may reduce the absorption of drugs that are sensitive to the pH level of the stomach (12).

    Purported uses

    • Acne
    • Atherosclerosis
    • Cancer treatment
    • Constipation
    • Diabetes
    • Fatigue
    • GI disorders
    • Headaches
    • Health maintenance
    • Hemorrhoids
    • HIV and AIDS
    • Hypertension
    • Immunostimulation
    • Osteoarthritis
    • Stress

    Constituents

    • Alcohol (0.5%) 
    • Acids: acetic acid, gluconic acid, lactic acid, glucuronic acid, hyaluronic acid, chondroitin sulfate acid.
    • Bacteria: Acetobacter species
    • Yeasts: Brettanomyces, Zygosaccharomyces, and Saccharomyces species (1) (2)

    Mechanism of Action

    Preparation of Kombucha tea yields a slightly carbonated, acidic, fermented drink. Researchers have demonstrated Kombucha's antimicrobial activity against a large number of pathogenic microorganisms even at neutral pH and after denaturation. This suggests that Kombucha contains antimicrobial compounds other than acetic acid and large proteins (13). In addition, Kombucha tea has been shown to have high levels of B vitamins (14). Because of the method of culture, it is easy for Kombucha to become contaminated with other organisms. Contamination with Anthrax (10) and Aspergillus (14), a fungus that is dangerous to people with lowered immune systems, have been reported. Green tea can stimulate the Kombucha fermentation better than black tea, however it is generally not used (3).

    Warnings

    • Growing Kombucha in unsanitary conditions has lead to contamination. 
    • Lead poisoning has been associated with Kombucha tea brewed in a glazed ceramic pot.

    Contraindications

    Patients with suppressed immune systems should not consume Kombucha beverages produced in an uncontrolled environment (1).

    Adverse Reactions

    Reported (Oral): stomach problems and yeast infections (12).
    Case Report (Topical): A case report of an outbreak of cutaneous anthrax in 20 people who had applied Kombucha grown in unhygienic conditions (10).
    Case Report (Oral): Case reports of severe illness and death (9) (17) have been associated with the consumption of Kombucha tea. Two cases of lead poisoning have been reported following drinking Kombucha tea brewed in a lead-glazed ceramic pot (15). Four cases of gastrointestinal toxicity have been reported from Kombucha as well, including two cases of allergic reaction, one case of jaundice and one case of nausea, vomiting, head and neck pain (11). One case of hepatotoxicity has also been reported following Kombucha tea consumption (2).

    Herb-Drug Interactions

    Kombucha tea is acidic. This may affect the bioavailability of drugs that depend on the pH levels of the stomach for dissolution and absorption(12).

    Literature Summary and Critique

    A systematic review of clinical evidence found no clinical trials on humans (8).

    References

    1. Mayser P, Fromme S, Leitzmann C, Grunder K. The yeast spectrum of the 'tea fungus Kombucha'. Mycoses 1995;38:289-95.
    2. Perron AD, Patterson JA, Yanofsky NN. Kombucha "mushroom" hepatotoxicity. Ann.Emerg.Med 1995;26:660-1.
    3. Greenwalt CJ, Steinkraus KH, Ledford RA. Kombucha, the fermented tea: microbiology, composition, and claimed health effects. J Food Prot. 2000;63:976-81.
    4. Majchrowicz M. Kombucha: a dubious "cure". GMHC.Treat.Issues 1995;9:10.
    5. Dipti P, Yogesh B, Kain AK, Pauline T, Anju B, Sairam M et al. Lead induced oxidative stress: beneficial effects of Kombucha tea. Biomed.Environ.Sci. 2003;16:276-82.
    6. Pauline T, Dipti P, Anju B, Kavimani S, Sharma SK, Kain AK et al. Studies on toxicity, anti-stress and hepato-protective properties of Kombucha tea. Biomed.Environ.Sci. 2001;14:207-13.
    7. Vijayaraghavan R, Singh M, Rao PV, Bhattacharya R, Kumar P, Sugendran K et al. Subacute (90 days) oral toxicity studies of Kombucha tea. Biomed.Environ.Sci. 2000;13:293-9.
    8. Ernst E. Kombucha: a systematic review of the clinical evidence. Forsch.Komplementarmed.Klass.Naturheilkd. 2003;10:85-7.
    9. Unexplained severe illness possibly associated with consumption of Kombucha tea--Iowa, 1995. From the Centers for Disease Control and Prevention. JAMA 1996;275:96-8.
    10. Sadjadi J. Cutaneous anthrax associated with the Kombucha "mushroom" in Iran. JAMA 1998;280:1567-8.
    11. Srinivasan R, Smolinske S, Greenbaum D. Probable gastrointestinal toxicity of Kombucha tea: is this beverage healthy or harmful? J Gen.Intern Med 1997;12:643-4.
    12. Kombucha--toxicity alert. Crit Path.AIDS Proj. 1994;31-2.
    13. Sreeramulu G, Zhu Y, Knol W. Kombucha fermentation and its antimicrobial activity. J Agric.Food Chem. 2000;48:2589-94.
    14. Gamundi R,.Valdivia M. [The Kombucha mushroom: two different opinions]. Sidahora. 1995;34-5.
    15. Phan TG, Estell J, Duggin G, Beer I, Smith D, Ferson MJ. Lead poisoning from drinking Kombucha tea brewed in a ceramic pot. Med J Aust. 1998;169:644-6.
    16. MICROMEDEX(R) Healthcare Series. 120. 2004. Thomson MICROMEDEX.
    17. SungHee Kole A, Jones HD, Christensen R, et al. A case of Kombucha tea toxicity. J Intensive Care Med. 2009 May-Jun;24(3):205-7.


    Last Updated: Aug. 13, 2009
    E-mail your questions and comments to aboutherbs@mskcc.org.
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