Computational chemist John Chodera uses statistical mechanics, molecular modeling, and automated biophysical experiments to help identify new potential therapeutics and investigate mechanisms of drug resistance in cancer.
Physician-scientist Michael Glickman investigates the physiology and pathogenic mechanisms of mycobacteria, including regulated intramembrane proteolysis (the Rip1 pathway); double-strand-break repair and associated DNA damage responses; and cell envelope biosynthesis.
Developmental biologist Danwei Huangfu investigates the fundamental mechanisms that govern cell identity and how they could be exploited therapeutically to manipulate cell fates in regenerative medicine.
Medical physicist Gikas Mageras focuses on radiation treatment planning and verification using CT images to guide radiation treatment and monitor and correct for patient internal and external movement during treatment delivery.
Structural biologist Dimitar Nikolov focuses on the structural, biophysical, and biochemical characterization of the molecular mechanisms of cell-cell interactions and signal transduction in the nervous system.
Cancer geneticist Kenneth Offit focuses on gene characterization; genetic and epidemiologic studies of cancer-predisposing alleles; and the therapeutic, prognostic, and psychosocial translation of these findings.
Molecular geneticist Elli Papaemmanuil performs systematic interrogations of well annotated clinical trial cohorts in leukemia and cancer to explore how the compound genetic and clonal architecture in patients leukemias and tumors dictate clinical phenotype, disease progression and clinical outcomes.
Structural biologist Alexandros Pertsinidis uses structural molecular and structural cell biology to study novel optical imaging and spectroscopy technologies to understand the function of complex macromolecular machines inside living cells.
Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.
Physician-scientist Jorge Reis-Filho focuses on the development of a predictive molecular classification for rare types of breast cancer and characterization of intratumor genetic heterogeneity in breast cancers.
Developmental biologist Lorenz Studer investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine.
Physician-scientist Laura Tang studies the molecular pathogenesis of cell transformation in neuroendocrine neoplasms of the gastrointestinal tract and pancreas and adenocarcinomas of the stomach and gastrointestinal junction.
Computational biologist Harel Weinstein investigates the structural, dynamic, and integrative determinants of molecular and cellular mechanisms underlying physiological function and pharmacological activity.
Medical physicist Pat Zanzonico focuses on radionuclide-based methods for detecting and localizing tumor hypoxia, immune effector-cell trafficking, patient-specific dosimetry for radionuclide therapies, and small-animal and molecular imaging.