Allis, David
Molecular Biology
The histone code and its impact on gene regulation and chromosome dynamics.
Allison, James P.
Chair, Immunology Program, SKI
Immunology
The T cell antigen receptor complex and its effect on T cell proliferation, survival, and cytokine production.
Altan-Bonnet, Grégoire
Computational Biology
Computationally probing and experimentally testing the integration of cellular activation that makes the immune response.
Amols, Howard I.
Chief, Clinical Physics Service
Memorial Hospital Research Laboratories
Development of advanced radiation therapy treatment techniques including image-guided radiation therapy and intensity-modulated radiation therapy.
Anderson, Kathryn V.
Chair, Developmental Biology Program, SKI
Developmental Biology
Genetic pathways that direct embryonic patterning and morphogenesis in the mouse embryo.
Antonescu, Cristina
Memorial Hospital Research Laboratories
Molecular pathogenesis of soft tissue sarcomas and gastrointestinal stromal tumors.
Bao, Zhirong
Developmental Biology
How the genome dictates development, with C. elegans as our models.
Baylies, Mary
Developmental Biology
Mechanisms underlying the specification and morphogenesis of muscle during development and disease.
Begg, Colin
Molecular Pharmacology & Chemistry
Statistical methods for cancer epidemiology, health services research, and clinical trials.
Benezra, Robert
Cancer Biology & Genetics
Molecular mechanisms of tumor growth and progression using mouse Id1 and Id3 knock-out models and analysis of the spindle assembly checkpoint.
Berger, Michael F.
Memorial Hospital Research Laboratories
Massively parallel sequencing of tumor DNA for biomarker discovery and clinical diagnostics.
Besmer, Peter
Developmental Biology
Normal and oncogenic receptor tyrosine kinase signaling in vitro and in vivo in mice.
Blasberg, Ronald G.
Molecular Pharmacology & Chemistry
Development of noninvasive imaging paradigms in living organisms using radionuclide and optical reporter systems.
Bradbury, Michelle S.
Memorial Hospital Research Laboratories
Development of translational silica nanomaterials and innovative imaging applications for cancer treatment.
Brennan, Cameron W.
Human Oncology & Pathogenesis Program
Genomic analysis of human and mouse gliomas and medulloblastomas.
Brentjens, Renier J.
Memorial Hospital Research Laboratories
Development of novel immunotherapies for leukemias and lymphomas.
Bromberg, Jacqueline
Memorial Hospital Research Laboratories
Aberrantly activated Stat3 and the mechanisms of Stat3-mediated transformation.
Carrasquillo, Jorge A.
Memorial Hospital Research Laboratories
Development of targeted radioimmunotherapy drugs.
Cartegni, Luca
Molecular Pharmacology & Chemistry
Role of alternative splicing events in the development and/or maintenance of cancer.
Carver, Brett S.
Memorial Hospital Research Laboratories
Identification of molecular pathways involved in prostate cancer initiation and progression.
Chaganti, Raju
Cell Biology
Genomic instability in cancer cells and its implications for clinical behavior of tumors and normal cellular developmental pathways.
Chan, Timothy A.
Human Oncology & Pathogenesis Program
Identification and characterization of tumor suppressors in glioblastoma and breast cancer.
Chandarlapaty, Sarat
Human Oncology & Pathogenesis Program
Regulation of growth factor signaling networks in cancer.
Chen, Yu
Human Oncology & Pathogenesis Program
The role of transcription factors that are critical for prostate cancer development.
Cheng, Emily H.
Human Oncology & Pathogenesis Program
The molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy.
Cheung, Nai-Kong
Memorial Hospital Research Laboratories
Engineering of antibodies and immune cells to treat solid tumors in children.
Chi, Ping
Human Oncology & Pathogenesis Program
Genetic and epigenetic regulation of oncogenic transcriptional programs in solid tumor pathogenesis.
Chiosis, Gabriela
Molecular Pharmacology & Chemistry
Pharmacological modulation of molecular chaperones in transformed systems.
Clarkson, Bayard
Molecular Pharmacology & Chemistry
Development of targeted therapies aimed at cancer stem cells.
Danishefsky, Samuel
Molecular Pharmacology & Chemistry
Synthesis of antitumor natural products and of fully synthetic carbohydrate-based vaccines.
Dave, Amita Shukla
Memorial Hospital Research Laboratories
Development of a program in multimodality imaging for head and neck cancer; development of new imaging criteria for prostate cancer.
Deasy, Joseph O.
Chair, Department of Medical Physics; Enid A. Haupt Chair in Medical Physics
Memorial Hospital Research Laboratories
Integration and analysis of dose, imaging, and molecular data to predict outcomes and guide personalized treatments.
DeMatteo, Ronald
Memorial Hospital Research Laboratories
Strategies to reduce immune subversion in gastrointestinal stromal tumor and liver cancer; immunobiology in liver cancer.
Deng, Liang
Memorial Hospital Research Laboratories
Poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.
Fagin, James
Human Oncology & Pathogenesis Program
Pathogenesis of thyroid cancer, role of oncogenic kinases.
Fong, Yuman
Memorial Hospital Research Laboratories
Herpes-based oncolytic viral therapies in the treatment of malignancy.
Fuks, Zvi
Molecular Pharmacology & Chemistry
Mechanisms of radiation-induced damage and the clinical basis of radiation resistance.
Funabiki, Hironori
Cell Biology
Regulation of the structure and configuration of chromosomes during the cell division cycle.
Giancotti, Filippo
Cell Biology
Signaling by cell adhesion receptors, neoplastic transformation, and metastatic dissemination.
Gin, David Y.
Molecular Pharmacology & Chemistry
Synthesis of complex glycoconjugate immunostimulants and anti-cancer, anti-viral natural products.
Glickman, Michael
Immunology
Physiology and pathogenic mechanisms of mycobacteria, including regulated intramembrane proteolysis (the Rip1 pathway), double-strand-break repair and associated DNA damage responses, and cell envelope biosynthesis.
Goldberg, Jonathan
Structural Biology
Structural and biochemical characterization of intracellular vesicle transport.
Goll, Mary
Developmental Biology
Mechanisms of epigenetic regulation and their roles in development using zebrafish as a model system.
Grimm, Jan
Molecular Pharmacology & Chemistry
Developing novel activatable molecular imaging approaches for improved detection and monitoring of prostate and other cancers.
Hadjantonakis, Anna-Katerina
Developmental Biology
Cell lineage commitment, tissue patterning, and morphogenesis in the early mammalian embryo.
Hall, Alan
Chair, Cell Biology Program, SKI
Cell Biology
Rho and Ras GTPases and the control of cell migration, morphogenesis, and polarity.
Hammerling, Ulrich
Immunology
Function of Vitamin A in the regulation of energy generation of mitochondria.
Haynes, Cole
Cell Biology
Molecular mechanisms of mitochondrial function during development, aging, and cancer cell growth.
Hedvat, Cyrus V.
Memorial Hospital Research Laboratories
Identification of clinically relevant genomic alterations in acute myeloid leukemia.
Holland, Eric C.
Cancer Biology & Genetics
Molecular mechanisms underlying the pathogenesis of CNS tumors and modeling of these cancers in the mouse.
Houghton, Alan
Immunology
The immune response to cancer, immune recognition of self and mutated molecules, and development of new immunotherapies.
Hricak, Hedvig
Molecular Pharmacology & Chemistry
Methodologies of molecular imaging of prostate and gynecologic tumors.
Hsieh, James J.
Human Oncology & Pathogenesis Program
Development of novel therapeutics targeting cancer cell proliferation and establishment of a translational kidney cancer program.
Hsu, Katharine C.
Memorial Hospital Research Laboratories
The biology of human natural killer cells and how they contribute to disease processes.
Huangfu, Danwei
Developmental Biology
The fundamental mechanisms that govern cell identity and how they could be exploited therapeutically to manipulate cell fates in regenerative medicine.
Humm, John L.
Memorial Hospital Research Laboratories
Noninvasive imaging of the tumor microenvironment using nuclear imaging methods.
Hurwitz, Jerard
Molecular Biology
Mechanisms of eukaryotic DNA replication and the isolation and characterization of the proteins involved.
Huse, Jason T.
Assistant Attending, Department of Pathology
Human Oncology & Pathogenesis Program
Molecular pathogenesis of brain tumors, particularly high-grade gliomas.
Jackson, Andrew
Memorial Hospital Research Laboratories
Relationship between radiotherapy dose-distributions and treatment outcome and the optimization of radiotherapy treatment planning.
Jallepalli, Prasad
Molecular Biology
Mechanisms of high-fidelity chromosome segregation in human cells.
Jasin, Maria
Developmental Biology
Double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.
Jiang, Xuejun
Cell Biology
Programmed cell death, molecular mechanisms, and their roles in tumorigenesis.
Joyce, Johanna
Cancer Biology & Genetics
Investigating the signaling pathways between cancer cells and their microenvironment in tumor progression, metastasis, and response to therapy.
Joyner, Alexandra
Developmental Biology
Involvement of Hedgehog signaling and homeobox transcription factors in brain development, adult stem cells, and cancer.
Kaltschmidt, Julia
Developmental Biology
Understanding the mechanisms of synaptic specificity underlying mammalian neuronal circuit formation.
Kelly, Thomas J.
Director, Sloan-Kettering Institute
Molecular Biology
Regulatory mechanisms that control DNA replication during the cell cycle of eukaryotic cells.
Kharas, Michael
Molecular Pharmacology & Chemistry
RNA regulators of self-renewal in both normal and leukemic hematopoieis.
Kim, Kitai
Cancer Biology & Genetics
Epigenetic regulation of DNA methylation in stem cells and cancer.
King, Tari A.
Memorial Hospital Research Laboratories
Molecular genetics of high-risk breast lesions and the transition from in situ to invasive breast carcinoma.
Kircher, Moritz F.
Memorial Hospital Research Laboratories
Development of novel molecular imaging approaches with a focus on surface enhanced Raman spectroscopy and magnetic resonance imaging.
Klein, Robert J.
Cancer Biology & Genetics
Identification of genes responsible for inherited predisposition to cancer.
Koff, Andrew
Molecular Biology
The role of cell cycle inhibitors in differentiation and how their loss affects tumorigenesis.
Kolesnick, Richard
Molecular Pharmacology & Chemistry
The role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.
Koutcher, Jason A.
Memorial Hospital Research Laboratories
Applications of magnetic resonance spectroscopy and imaging to enhance the therapeutic gain of different anti-neoplastic modalities.
Lacy, Elizabeth H.
Developmental Biology
Mechanisms of gastrulation and organogenesis during mouse development.
Ladanyi, Marc
Human Oncology & Pathogenesis Program
Molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.
Lai, Eric C.
Developmental Biology
Control of developmental patterning by Notch signaling and microRNAs.
Larson, Steven
Molecular Pharmacology & Chemistry
Molecular imaging in animals and humans using high-resolution diagnostic instruments, such as positron emission tomography, and single photon emission tomography.
Leslie, Christina
Computational Biology
Machine learning algorithms for computational and systems biology.
Levine, Douglas A.
Memorial Hospital Research Laboratories
Genomics of ovarian and endometrial cancers.
Levine, Ross L.
Human Oncology & Pathogenesis Program
Investigation of genetic basis of hematopoietic malignancies.
Lewis, Jason S.
Memorial Hospital Research Laboratories
Development of radiopharmaceuticals for the imaging and therapy of cancer.
Li, Gloria C.
Memorial Hospital Research Laboratories
Response of cells to stressors such as heat and radiation.
Li, Ming
Immunology
Mechanisms of T Cell homeostasis, tolerance, and immunity, and their relevance to autoimmune diseases and cancer.
Li, Yueming
Molecular Pharmacology & Chemistry
Function and regulation of transmembrane proteases and development of novel protease-based cancer therapies.
Lima, Christopher D.
Structural Biology
Structural biology of post-translational protein modification and RNA processing.
Ling, C. Clifton
Molecular Pharmacology & Chemistry
The study and noninvasive imaging of tumor hypoxia.
Liu, Jidong
Cell Biology
Molecular mechanism of RNA interference, function, and regulation of mammalian cytoplasmic processing bodies.
Livingston, Philip O.
Memorial Hospital Research Laboratories
Tumor vaccinology, including approaches to augmenting the antibody and T cell response to defined cancer antigens.
Long, Stephen B.
Structural Biology
Structural biology of ion channels and enzymatic membrane proteins.
Lowe, Scott W.
Cancer Biology & Genetics
Tumor-suppressor gene networks that control apoptosis and senescence.
Luo, Minkui
Molecular Pharmacology & Chemistry
Developing chemical tools to elucidate protein-posttranslational modification and designing inhibitors for cancer therapies.
Mageras, Gikas S.
Chief, Computer Service
Memorial Hospital Research Laboratories
Radiation treatment planning and verification using CT images to guide radiation treatment and monitor and correct for patient internal and external movement during treatment delivery.
Marians, Kenneth J.
Program Chair and Dean, Gerstner Sloan-Kettering Graduate School
Molecular Biology
Mechanisms of replication restart and chromosome segregation.
Marks, Paul A.
Cell Biology
The study of agents that selectively target histone deacetylases and cause transformed cell growth arrest, terminal differentiation, apoptosis, and/or cell death.
Massagué, Joan
Chair, Cancer Biology & Genetics Program, SKI
Cancer Biology & Genetics
Control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.
Mayr, Christine
Cancer Biology & Genetics
Gene regulation and definition of the end of an mRNA or a transcription unit.
Mehrara, Babak J.
Memorial Hospital Research Laboratories
Regulation of lymphatic regeneration after surgery and development of lymphedema.
Mellinghoff, Ingo K.
Human Oncology & Pathogenesis Program
Signal transduction alterations in primary brain tumors.
Moore, Malcolm A. S.
Cell Biology
The characterization of normal and cancer stem cells and development of selective therapies.
Niethammer, Philipp
Cell Biology
Investigation of wound responses in vertebrates on a systems biology level using advanced imaging approaches and genomic techniques.
Nikolov, Dimitar B.
Structural Biology
Structural, biophysical, and biochemical characterization of the molecular mechanisms of cell-cell interactions and signal transduction in the nervous system.
Nimer, Stephen
Molecular Pharmacology & Chemistry
Defining the molecular and biological abnormalities, and the underlying transcriptional regulation mechanisms involved in the development and growth of hematologic cancers.
O'Reilly, Richard J.
Immunology
Genetic disparities and cellular interactions between donor and host that affect allogeneic hematopoietic cell transplantation.
Offit, Kenneth
Memorial Hospital Research Laboratories
Cancer genetics: gene characterization, genetic/epidemiologic studies of cancer-predisposing alleles, and the therapeutic, prognostic, and psychosocial translation of these findings.
Overholtzer, Michael
Cell Biology
Mechanisms of tumor initiation / progression; cell adhesion; cell death.
Pamer, Eric G.
Immunology
T cell and innate inflammatory responses to bacterial and fungal infections.
Pan, Ying-Xian
Memorial Hospital Research Laboratories
Transcription regulation and function of opioid receptor genes.
Park, Christopher Y.
Human Oncology & Pathogenesis Program
Identification and characterization of molecular pathways that regulate normal and malignant stem cells in the hematopoietic system.
Pasternak, Gavril W.
Molecular Pharmacology & Chemistry
Molecular mechanisms of opioid receptor actions, analgesics, and G-protein-coupled receptors.
Patel, Dinshaw
Structural Biology
Structural biology of macromolecular recognition: RNA catalysis, RNA interference, and bypass of DNA damage.
Pavletich, Nikola
Chair, Structural Biology Program, SKI
Structural Biology
Structural biology of oncogenes and tumor suppressors.
Pertsinidis, Alexandros
Structural Biology
Structural molecular and structural cell biology using novel optical imaging and spectroscopy technologies to understand the function of complex macromolecular machines inside living cells.
Petrini, John
Molecular Biology
Repair of chromosomal breaks and the activation of the DNA damage-induced cell cycle checkpoints.
Ponomarev, Vladimir
Memorial Hospital Research Laboratories
Development of new reporter genetic systems for specific applications such as sequential in-vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.
Powell, Simon N.
Molecular Biology
DNA replication and recombination, chromosome dynamics, and human genetics.
Rajadhyaksha, Milind
Memorial Hospital Research Laboratories
Confocal microscopy for imaging of cancer; technology development and translational/clinical studies in skin and head-and-neck cancers.
Resh, Marilyn
Cell Biology
Regulation of protein function by fatty acylation; development of Hedgehog palmitoylation inhibitors to block pancreatic cancer.
Rosen, Neal
Molecular Pharmacology & Chemistry
Understanding biochemical mechanisms underlying phenotypes caused by tyrosine kinase activation in epithelial tumors and the development of new therapeutic strategies.
Rudensky, Alexander
Immunology
Immunological tolerance and the differentiation and function of T cells.
Rutishauser, Urs Stephen
Cell Biology
The role of polysialic acid in regulating the nervous system and the use of polysialic acid to promote tissue repair.
Ryan, Timothy A.
Cell Biology
The study of the molecular basis of synaptic transmission in the mammalian brain.
Sadelain, Michel
Molecular Pharmacology & Chemistry
Mechanisms governing transgene expression, stem cell engineering, and genetic strategies to enhance immunity against cancer.
Sander, Chris
Chair, Computational Biology Program, SKI
Computational Biology
Using computational biology to analyze and simulate biological processes at different levels of organization.
Sawyers, Charles L.
Chair, Human Oncology and Pathogenesis Program
Human Oncology & Pathogenesis Program
Molecularly targeted cancer therapy.
Scheinberg, David
Chair, Molecular Pharmacology & Chemistry Program, SKI
Molecular Pharmacology & Chemistry
Discovery and development of novel, specific immunotherapeutic agents and targeted nanodevices for cancer therapy.
Schwartz, Gary
Memorial Hospital Research Laboratories
Identification of cell cycle inhibitors which promote chemotherapy induced apoptosis and their use in cancer therapy.
Shi, Songhai
Developmental Biology
Molecular and cellular mechanisms underlying mammalian neuronal development and circuit formation.
Shuman, Stewart
Molecular Biology
Mechanisms and structures of the mRNA cap-forming enzymes and the means by which capping is coupled to transcription.
Singer, Sam
Memorial Hospital Research Laboratories
Genomic alterations that define new targets for therapy in sarcoma.
Singh, Bhuvanesh
Memorial Hospital Research Laboratories
Delineation of the role of ubiquitination in cancer pathogenesis.
Solit, David B.
Human Oncology & Pathogenesis Program
Human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
Spriggs, David R.
Memorial Hospital Research Laboratories
Molecular mechanisms of drug resistance in ovarian cancer.
Studer, Lorenz
Developmental Biology
Stem cells as tool to understand normal and pathological development in the CNS and to develop cell based strategies for neural repair.
Tabar, Viviane
Memorial Hospital Research Laboratories
In vivo applications of neural derivatives of pluripotent stem cells (iPS, ES); cancer stem cells in human brain tumors.
Tan, Derek S.
Molecular Pharmacology & Chemistry
Diversity-oriented synthesis and rational drug design for chemical biology and drug discovery in cancer and infectious disease.
Tang, Laura H.
Memorial Hospital Research Laboratories
Molecular pathogenesis of cell transformation in neuroendocrine neoplasms of the gastrointestinal tract and pancreas and adenocarcinoma of the stomach and gastrointestinal junction.
Tempst, Paul
Molecular Biology
Development of proteomic technologies and approaches for studying the eukaryotic transcriptional machineries and for cancer biomarker discovery.
Thakur, Sunitha B.
Memorial Hospital Research Laboratories
MR biomarkers for early detection and monitoring response to treatment.
Thompson, Craig B.
Cancer Biology & Genetics
Molecular signaling pathways that regulate nutrient uptake and the role these pathways play in the regulation of cell growth and survival.
Tolwinski, Nicholas S.
Developmental Biology
The molecular mechanisms by which cells respond to signals and how the Wingless/Wnt pathway functions in cell behavior.
Tsou, Meng-Fu Bryan
Cell Biology
Cell cycle control of centrosome duplication/degeneration and cilia assembly/disassembly.
Weinstein, Harel
Computational Biology
Structural, dynamic and integrative determinants of molecular and cellular mechanisms underlying physiological function and pharmacological activity.
Weiser, Martin R.
Memorial Hospital Research Laboratories
Investigation of the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.
Wendel, Hans-Guido
Cancer Biology & Genetics
Modeling the genetics of tumor initiation, progression, and treatment response in vivo.
Whitehouse, Iestyn
Molecular Biology
Chromatin structure and the function of ATP dependent chromatin remodelling enzymes.
Wolchok, Jedd D.
Immunology
Tumor immunology and novel approaches for cancer immunotherapy; mechanisms of tumor cell-immune cell interactions.
Wong, Richard J.
Memorial Hospital Research Laboratories
Mechanisms of cancer cell chemotaxis in perineural invasion.
Xavier, Joao
Computational Biology
Computational models and quantitative experiments of biofilm and cancer growth.
Young, James W.
Memorial Hospital Research Laboratories
Innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.
Zallen, Jennifer
Developmental Biology
Generation of tissue structure through the collective action of cell populations.
Zanzonico, Pat B.
Memorial Hospital Research Laboratories
Radionuclide-based methods for detecting and localizing tumor hypoxia, immune effector-cell trafficking, patient-specific dosimetry for radionuclide therapies, and small-animal and molecular imaging.
Zhao, Xiaolan
Molecular Biology
Chromosomal organization, telomere metabolism, DNA repair, and dynamic protein modification in stable genome maintenance.
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