Andrew Vickers, PhD

Methodology of Anticancer Research

1. Vickers AJ, Elkin EB. Decision curve analysis: a novel method for evaluating prediction models. Medical Decision Making (in press)
2. Vickers AJ, Kramer BS, Baker SG. Selecting patients for randomized trials: a systematic approach based on risk group. Trials 2006; 7(1):30
3. Vickers AJ, Ballen V, Scher HI. Setting the bar in Phase II trials: the use of historical data for determining “go / no go” decision for definitive phase III testing. Clinical Cancer Research (in press)
4. Elkin EB, Vickers AJ, Kattan MW. Primer: using decision analysis to improve clinical decision making in urology. Nature Clinical Practice Urology 2006:3:439-448
5. Vickers AJ. Whose data set is it anyway? Sharing raw data from randomized trials. Trials 2006:7:15
6. Vickers AJ. How to design a Phase I trial of an anticancer botanical. Journal of the Society for Integrative Oncology 2006;4:46-51
7. Tao Y, Klause A, Vickers A, Bae K, Ellis M. Clinical and Biomarker Endpoint Analysis in Neoadjuvant Endocrine Therapy Trials. J Steroid Biochem Mol Biol 2005; 95:91-5.
8. Vickers AJ. How to interpret data from randomized trials. The Scandinavian prostatectomy study illustrates two common errors. Nature Clinical Practice Urology 2005;9:2-3
9. Kattan MW, Vickers AJ. Incorporating predictions of individual patient risk in clinical trials. Urologic Oncology 2004;22(4):348-52
10. Vickers AJ. Botanical medicines for the treatment of cancer: rationale, overview of current data and methodological considerations for Phase I and II trials. Cancer Investigation 2002;20(7-8):1069-79

Surgical Urology

1. Koppie TM, Vickers AJ, Vora K, Dalbagni G, Bochner BH. Standardization of pelvic lymphadenectomy performed at radical cystectomy: Can we establish a minimum number of lymph nodes that should be removed? Cancer (in press)
2. Bochner B, Vickers AJ, Ganesh R, Martinez Salamanca J, Koppie T, Secin F. An evaluation of regional lymph node dissection in patients with upper urinary tract urothelial cancer. International Journal of Urology (in press)
3. Raj GV, Tal R, Vickers AJ, Bochner BH, Serio A, Donat SM, Herr H, Olgac S, Dalbagni G. Significance of intraoperative ureteral evaluation at radical cystectomy for urothelial cancer. Cancer. 2006 (in press)
4. Raj GV, Bochner BH, Serio AM, Vickers AJ, Donat SM, Herr H, Lin O, Dalbagni G. Natural history of patients with positive urinary cytologies after radical cystectomy. Journal of Urology2006;176(5):2000-5
5. Sandhu JS, Vickers AJ, Bochner B, Donat SM, Herr HW, Dalbagni G. Clinical characteristics of bladder cancer in patients previously treated with radiation for prostate cancer. BJU International 2006;98(1):59-62
6. Secin FP, Bianco FJ, Vickers AJ, Fearn P, Scardino PT, Eastham JA. Cancer-specific survival and predictors of prostate-specific antigen recurrence and survival in patients with seminal vesicle invasion after radical prostatectomy. Cancer 2006;106(11):2369-75
7. Touijer K, Kuroiwa K, Vickers AJ, Reuter VE, Guillonneau B. Impact of a multidisciplinary continuous quality improvement program on the positive surgical margin rate after laparoscopic radical prostatectomy. European Urology 2006;49(5):853-8
8. Dash A, Galsky MD, Vickers AJ, Serio AM, Koppie TM, Dalbagni G, Bochner BH. Impact of renal impairment on eligibility for adjuvant cisplatin-based chemotherapy in patients with urothelial carcinoma of the bladder. Cancer. 2006; 107(3):506-13
9. Huang WC, Levey AS, Serio AM, Snyder M, Vickers AJ, Raj G, Scardino PT, Russo P. Chronic kidney disease following nephrectomy in patients with renal cortical tumors. Lancet Oncology 2006;7(9):735-40.
10. Yossepowitch O, Eggener SE, Serio A, Huang WC, Snyder ME, Vickers AJ, Russo P. Temporary renal ischemia during nephron-sparing surgery is associated with short-term but not long-term impairment of renal function. Journal of Urology 2006;176(4):1339-43
11. Donohue JF, Bianco FJ, Kuroiwa K, Vickers AJ, Wheeler TM, Scardino PT, Reuter V, Eastham JA. Poorly differentiated prostate cancer treated by radical prostatectomy: Long-term outcome and incidence of downgrading. Journal of Urology 2006; 176(3):991-5
12. Carver BS, Bianco FJ, Shavegan B, Vickers AJ, Motzer RJ, Bosl GJ, Sheinfeld J. Predicting teratoma in the retroperitoneum for men undergoing post-chemotherapy retroperitoneal lymph node dissection. Journal of Urology 2006;176(1):100-4
13. Raj GV, Bochner BH, Vickers AJ, Teper E, Lin O, Donat SM, Herr H, Dalbagni G. Association between urinary cytology and pathology for nontransitional cell malignancies of the urinary tract. Journal of Urology 2006;175(6):2038-41
14. Dash A, Vickers AJ, Schacter L, Bach A, Snyder M, Russo P. Elective partial versus elective radical nephrectomy for clear cell renal cell carcinoma 4-7 cm in size. BJU International 2006; 97(5):939-45
15. DiBlasio CJ, Masterson TA, Fearn PA, Seo HS, Rabbani F, Vickers AJ, Eastham JA, Scardino PT. The association between total and positive lymph node counts, disease progression in clinically localized prostate cancer. Journal of Urology 2006;175(4):1320-4
16. Sandhu JS, Vickers AJ, Bochner B, Donat SM, Herr HW, Dalbagni G. Clinical Characteristics of Bladder Cancer in Patients Previously Treated with Radiation for Prostate Cancer. BJU International 2006;98(1):59-62
17. Secin FP, Bianco FJ, Vickers AJ, Fearn P, Scardino PT, Eastham JA. Characteristics, Predictors of recurrence and survival of patients with seminal vesicle invasion after radical prostatectomy. Cancer 2006;106(11):2369-75
18. Touijer K, Kuroiwa K, Vickers AJ, Reuter VE, Guillonneau B. . Impact of a multidisciplinary continuous quality improvement program on the positive surgical margin rate after laparoscopic radical prostatectomy. European Urology 2006;49(5):853-8
19. Vickers AJ, Bianco FJ, Boorjian S, Scardino P, Eastham JA. Does delay between diagnosis and radical prostatectomy increase the risk of cancer recurrence? Cancer 2006;106(3):576-80
20. Secin FP, Karanikolas N, Kuroiwa K, Vickers A, Touijer K, Guillonneau B. Positive surgical margins and accessory pudendal artery preservation during laparoscopic radical prostatectomy. Eur Urol. 2005; 48(5):786-92
21. Secin FP, Karanikolas N, Touijer AK, Salamanca JI, Vickers AJ, Guillonneau B. Anatomy of accessory pudendal arteries in laparoscopic radical prostatectomy. J Urology 2005;174(2):523-6.

Biomarkers and Medical Prediction

1. Lilja H, Ulmert D, Björk T, Becker C, Serio AM, Nilsson JA, Abrahamsson PA, Vickers AJ, Berglund G. Long-term prediction of prostate cancer in a large, representative Swedish cohort: prostate kallikreins measured at age 44-50 predict prostate cancer up to 25 years before diagnosis. Journal of Clinical Oncology (in press)
2. Steuber T, Vickers AJ, Haese A, Danø K, Høyer-Hansen G, Kattan MW, Eastham JA, Scardino PT, Huland H, Lilja H. Free PSA isoforms and intact and cleaved forms of urokinase plasminogen activator receptor in serum improve selection of patients for prostate cancer biopsy. International Journal of Cancer (in press)
3. Khokhar A, Vickers AJ, Moore MS, Mironov S, Stover DE, Feinstein MB. Significance of non-calcified pulmonary nodules among patients with extra-pulmonary cancers. Thorax 2006;61(4):331-6
4. Cheung NKV, Vickers AJ, Gorlick R. FcγRIIa polymorphism correlates with treatment outcome of metatastic neuroblastoma following immunotherapy using murine IgG3 anti-GD2 antibody and GM-CSF. Journal of Clinical Oncology 2006;24(18):2885-90
5. Cheung IY, Vickers AJ, Cheung NK. Sialyltransferase STX (ST8SiaII): a novel molecular marker of neuroblastoma. International Journal of Cancer 2006;119(1):152-6
6. Steuber T, Vickers AJ, Haese A, Becker C, Pettersson K, Chun FK-H, Kattan MW, Eastham JA, Scardino PT, Huland H, Lilja H. Risk assessment for biochemical recurrence prior to radical prostatectomy: Significant enhancement contributed by human glandular kallikrein 2 and free prostate-specific antigen (PSA) in men with moderate PSA-elevation in serum. International Journal of Cancer 2006;118(5):1234-40
7. Jenkins M, Vickers AJ. Poor reliability of IgE / IgG4 antibody testing as a diagnostic tool in food intolerance. Clinical and Experimental Allergy 1998;28:1526-9

Alternative Cancer Treatments

1. Vickers A. Alternative cancer cures: “unproven” or “disproven”? CA Cancer J Clin. 2004;54(2):110-8.
2. Risberg T, Vickers AJ, Bremnes RM, Wist EA, Kaasa S, Cassileth BR. Does alternative medicine use predict survival in cancer? European Journal of Cancer 2003;39: 372-377

Laboratory Research

1. Cheung NK, Modak S, Vickers AJ. Physical chemical characterization of oral -glucan that enhances anti-tumor effects of antibodies in mice. Cancer Immunology and Immunotherapy 2002;51(10):557-64
2. Modak S, Koehne G, Vickers A, O'Reilly RJ, Cheung NK. Rituximab therapy of lymphoma is enhanced by orally administered beta-glucan. Leukemia Research 2005;29:679-83
3. Lassman AB, Dai C, Fuller GN, Vickers A, Holland EC. Overexpression of c-Myc promotes an undifferentiated phenotype in cultured astrocytes and allows elevated Ras and Akt signaling to induce gliomas from GFAP-expressing cells in mice. Neuron Glia Biology 2004;1:157-163
4. Lin H, Simm MS, Cassileth BR, Vickers AJ, Cunninham-Rundles S. Maitake D-fraction reduces hematopoietic toxicity of Doxorubicin for human cord blood stem cells. Proc Amer Assoc Cancer Res 44:2758;2003

Clinical Trials of Complementary Therapies For Symptom Control

1. Vickers AJ, Rusch VW, Malhotra VT, Downey RJ, Cassileth BR. Acupuncture is a feasible treatment for post-thoracotomy pain: Results of a prospective clinical trial. BMC Anaesthesia 2006;6:5
2. Vickers AJ, Feinstein MB, Deng GE, Cassileth BR Acupuncture for dyspnea in advanced cancer: a randomized, placebo-controlled pilot trial (ISRCTN89462491). BiomedCentral Palliative Medicine 2005;4(1):5
3. Cassileth BR, Vickers AJ. Massage therapy for symptom control: Outcome study at a major cancer center. Journal of Pain and Symptom Management 2004;28:244-9
4. Vickers AJ. Cassileth BR. Strauss D. Acupuncture for post-chemotherapy fatigue: a Phase II study. Journal of Clinical Oncology 2004;22(9):1731-5
5. Vickers AJ, Rees RW, Zollman CE, McCarney R, Smith C, Ellis N, Fisher P, Van Haselen R. Acupuncture for chronic headache in primary care: a large, pragmatic, randomised trial. British Medical Journal 2004;328:744-7
6. Wonderling D, Vickers AJ, Grieve R, McCarney R. Cost-effectiveness analysis of a randomised trial of acupuncture for migraine and chronic tension headache in primary care. British Medical Journal 2004;328:747-9
7. Cassileth BR, Vickers AJ, Magill LA. Music therapy for mood disturbance during hospitalization for autologous stem cell transplantation: a randomized controlled trial. Cancer 2003;98(12):2723-2729
8. Irnich D, Behrens N, Gleditsch JM, Stör W, Schrieber MA, Schöps P, Vickers AJ, Beyer A. Immediate effects of dry needling and acupuncture at distant points in chronic neck pain: results of a randomized, double-blind, sham-controlled crossover trial. Pain 2002;99(1-2):83-9
9. Vickers AJ, Fisher P, Smith C, Wyllie SE, Rees RW. Homoeopathic Arnica 30x is ineffective for muscle soreness after long-distance running: a randomised, double-blind, placebo-controlled trial. Clinical Journal of Pain 1998;14:227-31

Methodology of Symptom Control and Quality of Life Studies

1. Vickers AJ. How to randomize. Journal of the Society for Integrative Oncology 2006;4(4):194-8
2. Vickers AJ. Multiple assessment in quality of life trials: how many questionnaires? How often should they be given? Journal of the Society for Integrative Oncology 2006;4:135-139
3. Vickers AJ. How to measure quality of life in integrative oncology research. Journal of the Society for Integrative Oncology 2006;4:100-103
4. Vickers AJ. Parametric versus non-parametric statistics in the analysis of randomized trials with non-normally distributed data. BiomedCentral Medical Research Methodology 2005;5:35
5. Vickers AJ. Analysis of variance is easily misapplied in the analysis of randomized trials: a critique and discussion of alternative statistical approaches. Psychosomatic Medicine 2005;67:652-5
6. Vickers AJ. Statistical reanalysis of four recent randomized trials of acupuncture for pain using analysis of covariance. Clinical Journal of Pain 2004;20(5):319-23
7. Vickers AJ. Statistical considerations for use of composite health-related quality-of-life scores in randomized trials. Quality of Life Research 2004;13 :717 -723
8. Vickers AJ, McCarney R. Use of a single global assessment to reduce missing data in a clinical trial with follow-up at one year. Controlled Clinical Trials 2003;24(6):731-5
9. Vickers AJ. How many repeated measures in repeated measures designs? Statistical issues for comparative trials. Biomed Central Medical Research Methodology 2003;3:22
10. Vickers AJ. Underpowering in randomized trials reporting a sample size calculation. Journal of Clinical Epidemiology 2003;56(8):717-20
11. Vickers AJ, Altman DG. Analysing controlled trials with baseline and follow-up measurements. British Medical Journal 2001;323:1123-1124
12. Vickers AJ. The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study. Biomed Central Medical Research Methodology 2001;1:6
13. Vickers AJ. Time course of muscle soreness following different types of exercise. Biomed Central Musculoskelet Disord 2001;2(1):5
14. Vickers AJ. de Craen AJM. Why use placebos in clinical trials? A narrative review of the methodological literature. Journal of Clinical Epidemiology 2000;53(2):157-161
15. Vickers AJ. Comparison of an ordinal and a continuous measure of muscle soreness. International Journal of Technology Assessment in Health Care 1999;15:709-16
16. de Craen AJM, Vickers AJ, Tijssen JGP , Kleijnen J. The number-needed-to-treat and placebo-controlled trials. Lancet 1998;351:310

Systematic Reviews and Meta-analyses

1. Ezzo JM, Richardson MA, Vickers AJ, Allen C, Dibble SL, Issell BF, Lao L, Pearl M, Ramirez G, Roscoe JA, Shen J, Shivnan JC, Streitberger K, Treish I, Zhang G. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD002285.
2. Ezzo JM, Vickers AJ, Richardson MA, Allen C, Dibble SL, Issell BF, Lao L, Pearl M, Ramirez G, Roscoe JA, Shen J, Shivnan JC, Streitberger K, Treish I, Zhang G. Acupuncture-Point Stimulation for Chemotherapy-Induced Nausea and Vomiting: a systematic review. Journal of Clinical Oncology 2005; 23(28):7188-98
3. Linde K, ter Riet G, Hondras M, Vickers A, Saller R, Melchart D. Systematic reviews of complementary therapies. Part 2: Herbal Medicine. BMC Complementary and Alternative Medicine 2001;1:5
4. Linde K, Vickers A, Hondras M, ter Riet G, Thormaehlen J, Berman B, Melchart D. Systematic reviews of complementary therapies. Part 1: Acupuncture. BMC Complementary and Alternative Medicine 2001;1:3
5. Vickers AJ, Smith C. Oscillococcinum in the prevention and treatment of influenza and influenza-like syndromes. (Cochrane Review) In: The Cochrane Library, Issue 4, 1999. Oxford: Update Software.
6. Melchart D, Linde K, Fischer P, White A, Allais G, Vickers AJ, Berman B. Acupuncture for chronic headache: a systematic review of randomized controlled trials. Cephalalgia. 1999;19:779-86
7. Vickers AJ, Ohlsson A, Lacy JB, Horsley A. Massage therapy for premature and/or low birth-weight infants to improve weight gain and/or to decrease hospital length of stay. (Cochrane Review) In: The Cochrane Library, Issue 3. Oxford: Update Software; 1998.
8. Vickers AJ. Can acupuncture have specific effects on health? A systematic review of acupuncture antiemesis trials. Journal of the Royal Society of Medicine 1996;89:303-11

Methodology of Systematic Reviews

1. Vickers AJ, Smith C. Incorporating data from dissertations in systematic reviews. International Journal of Technology Assessment in Health Care 2000;16(2):711-3
2. Vickers AJ, Harland R, Goyal N, Rees R. Do certain countries produce only positive results? A systematic review of controlled trials. Controlled Clinical Trials 1998;19:159-66

Other Cancer Studies

1. Vickers AJ, Kuo J, Cassileth BR. Unconventional anticancer agents: a systematic review of clinical trials. Journal of Clinical Oncology 2006;24(1):136-40
2. Su YB, Vickers AJ, Zelefsky MJ, Kraus DH, Shaha AR, Shah JP, Serio AM, Barrison LB, Bosl GJ, Pfister DG. Double-blind, placebo-controlled, randomized trial of granulocyte-colony stimulating factor (G-CSF) during post-operative radiotherapy for squamous head and neck cancer. Cancer Journal Cancer Journal 2006;12(3):182-8

Surveys and Sociologic Research

1. Cassileth BR, Schraub S, Robinson E, Vickers A. Alternative medicine use worldwide: The International Union Against Cancer survey. Cancer 2001;91(7):1390-3
2. Rees RW, Feigel I, Vickers A, Zollman C, McGurk R, Smith C. Prevalence of complementary therapy use by women with breast cancer. a population-based survey. Eur J Cancer 2000;36(11):1359-64
3. Vickers AJ, Rees RW, Robin A. Advice given by health food shops: is it clinically safe? Journal of the Royal College of Physicians of London 1998;32:426-8

Methodology of Complementary Medicine Research

1. Vickers AJ. Placebo controls in randomized trials of acupuncture. Evaluation and the Health Professions 2002;25(4):421-35
2. Vickers A, Cassileth B, Ernst E, Fisher P, Goldman P, Jonas W, Kang S, Lewith G, Schulz K, Silagy C. How should we research unconventional therapies? A panel report from the conference on Complementary and Alternative Medicine Research Methodology, National Institutes of Health. International Journal of Technology Assessment in Health Care 1997;13:111-21
3. Vickers AJ. Methodological issues in complementary and alternative medicine research. Journal of Alternative and Complementary Medicine 1996;2:515-24
4. Vickers AJ. Old myths given new voice. The Nuffield Report. Complementary Therapies in Medicine 1996;4:198-201

Reviews

1. Cassileth BR, Vickers AJ. Complementary therapy. In: Prostate Cancer. Ed by P Carroll and A D'Amico. New York: Lippincott, Williams and Wilkins 2004
2. Vickers AJ, Zollman CE. Complementary therapies. In: Jones R, Britten N, Culpepper L, Gass D, Grol R, Mant D, Silagy C, editors. Oxford Textbook of Primary Medical Care. Oxford: Oxford University Press, 2003
3. Cassileth BR, Vickers AJ. Localized Prostate Cancer: Complementary and alternative therapies. Urologic Clinics of North America 2003;30:369-76
4. Cassileth BR, Vickers AJ. Questionable cancer therapies. In: Cancer Medicine Ed by JF Holland, E Frei, R Bast, D Kufe, R Pollock, R Weichselbaum. Hamilton, Canada: BC Decker Inc, 2002.
5. Vickers AJ. Complementary and Alternative Medicine for Cancer. In: Physicians' Information and Education Resource [online database]. Philadelphia, American College of Physicians-American Society of Internal Medicine, 2002.
6. Vickers AJ, Cassileth BR. Complementary and alternative medicine approaches in colorectal cancer. In: Colorectal cancer: multimodality management. Ed by Saltz L. Totowa, NJ: Humana (2002)
7. Vickers AJ, Cassileth BR. A review of unconventional therapies used for treatment of cancer and cancer-related symptoms. Lancet Oncology 2001;2:226-32
8. Vickers AJ. Recent advances in complementary medicine. British Medical Journal 2000:321(7262):683-6
9. Vickers AJ, Christos P. Bezwoda: evidence of fabrication in original paper. Journal of Clinical Oncology 2000;18(15):2933
10. Vickers AJ. Why aromatherapy works (even if it doesn't) and why we need less research [editorial]. British Journal of General Practice 2000;50:444-5
11. Vickers AJ. Complementary medicine. In: Sackett D, Straus S, Richardson S, Rosenberg W & Haynes B (Eds). Evidence-Based Medicine: How to Practise and Teach EBM. London: Harcourt Brace (2000)
12. Zollman CE, Vickers AJ. ABC of complementary medicine: Complementary medicine and the doctor. British Medical Journal 1999;319:1558-61
13. Zollman CE, Vickers AJ. ABC of complementary medicine: Complementary medicine and the patient. British Medical Journal 1999;319:1486-9
14. Zollman CE, Vickers AJ. ABC of complementary medicine: Unconventional approaches to nutritional medicine. British Medical Journal 1999;319:1419-22
15. Vickers AJ, Zollman CE. ABC of complementary medicine: Hypnosis and relaxation therapies. British Medical Journal 1999;319:1346-9
16. Vickers AJ, Zollman CE. ABC of complementary medicine: Massage therapies. British Medical Journal 1999;319:1254-7
17. Vickers AJ, Zollman CE. ABC of complementary medicine: The manipulative therapies: osteopathy and chiropractic. British Medical Journal 1999;319:1176-9
18. Vickers AJ, Zollman CE. ABC of complementary medicine: Homoeopathy. British Medical Journal 1999;319:1115-8
19. Vickers AJ, Zollman CE. ABC of complementary medicine: Herbal medicine. British Medical Journal 1999;319:1050-3
20. Vickers AJ, Zollman CE. ABC of complementary medicine: Acupuncture. British Medical Journal 1999;319:973-6
21. Zollman CE, Vickers AJ. ABC of complementary medicine: Complementary medicine in conventional practice. British Medical Journal 1999;319:901-4
22. Zollman CE, Vickers AJ. ABC of complementary medicine: Users and practitioners of complementary medicine. British Medical Journal 1999;319:836-8
23. Zollman CE, Vickers AJ. ABC of complementary medicine: What is complementary medicine?. British Medical Journal 1999;319:693-6
24. Ezzo J, Berman BM, Vickers AJ, Linde K. Complementary Medicine, Evidence-based Medicine and the Cochrane Collaboration. Journal of the American Medical Association 1998;280:1628-30
25. Vickers AJ. Evidence-based medicine and complementary medicine[editorial]. Evidence-Based Medicine 1998;3:168-9
26. Vickers AJ. Research, uncertainty and alternative medicine [editorial]. Cancer Prevention International 1996;2:179-80