Sloan-Kettering Institute // Structural Biology Program

Christopher D. Lima, PhD

Pictured: Christopher Lima

In this lab

We are a basic research laboratory that studies the structural, biochemical, and functional basis for macromolecules involved in post-translational protein modification by SUMO, an ubiquitin-like protein modifier, and pathways that contribute to co-transcriptional RNA maturation and post-transcriptional RNA decay.

Publications

Armstrong AA, Mohideen F, Lima CD. Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature. 2012 Feb 29;483(7387):59-63. doi: 10.1038/nature10883.

Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 2010 Feb 18;463(7283):906-12. doi: 10.1038/nature08765.

Reverter D, Lima CD. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature. 2005 Jun 2;435(7042):687-92.

Wasmuth EV, Lima CD. Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel. Mol Cell. 2012 Oct 12;48(1):133-44. doi: 10.1016/j.molcel.2012.07.012. Epub 2012 Aug 16.

Liu Q, Greimann JC, Lima CD. Reconstitution, activities, and structure of the eukaryotic RNA exosome. Cell. 2006 Dec 15;127(6):1223-37.

On Our Blog
Recommended Links
Office phone:
212-639-8205
Office fax:
212-717-3047
Laboratory phone:
212-639-8170 / 8057 / 8763
Laboratory fax:
212-717-3047
E-mail:
limac@mskcc.org
Affiliations
Selected Achievements

Investigator, Howard Hughes Medical Institute (2013)

Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan-Kettering Cancer Center (2006)

Scholar, Rita Allen Foundation (2003-2006)

Mayor's Award for Excellence in Science and Technology, NYC Department of Cultural Affairs and New York Academy of Sciences (2003)

Young Investigator Award, Arnold and Mabel Beckman Foundation (1999-2002)