Read up on the latest publications in diversity-oriented synthesis, rational drug design, and chemical biology research from the Tan Lab!

            Selected Publications:
            Complete Publications:

Full-text versions of articles are available from the publisher with online journal subscription. PubMed Central (PMC) versions of articles are available free of charge.

2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | Postdoctoral | Graduate | Undergraduate ]

Tan Lab Publications

  1. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.
    Davis, T. D.; Gerry, C. J.; Tan, D. S.* ACS Chem. Biol. 2014, 9, 2535–2544.
    Abstract | PubMed | PMC ]
    (Highlighted in ACS Chem. Biol.)

  2. Solvent-dependent divergent functions of Sc(OTf)3 in stereoselective epoxide-opening spiroketalizations.
    Sharma, I.; Wurst, J. M.; Tan, D. S.* Org. Lett. 2014, 16, 2474–2477.
    Abstract | PubMed | PMC ]

  3. Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice.
    Lun, S.; Guo, H.; Adamson, J.; Cisar, J. S.; Davis, T. D.; Sundaramn Chavadi, S.; Warren, J. D.; Quadri, L. E. N.*; Tan, D. S.*; Bishai, W. R.* Antimicrob. Agents Chemother. 2013, 57, 5138–5140.
    Abstract | PubMed | PMC  ]

  4. Diversifying complexity.
    Sharma, I.; Tan, D. S.* Nat. Chem. 2013, 5, 157–158.
    Abstract | PubMed ]

  5. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion.
    Bauer, R. A.; Wenderski, T. A.; Tan, D. S.* Nat. Chem. Biol. 2013, 9, 21–29.
    Abstract | PubMed | PMC ]

  6. Stereoselective synthesis of acortatarins A and B.
    Wurst, J. M.; Verano, A. L.; Tan, D. S.* Org. Lett. 2012, 14, 4442–4445.
    Abstract | PubMed  | PMC ]

  7. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion.
    Kopp, F.; Stratton, C. F.; Akella, L. B.; Tan, D. S.* Nat. Chem. Biol. 2012, 8, 358–365.
    Abstract | PubMed | PMC ]
    (Highlighted in SciBX )

  8. Stable analogues of OSB-AMP: Potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquninone biosynthesis.
    Lu, X.; Zhou, R.; Sharma, I.; Li, X.; Kumar, G.; Swaminathan, S.; Tonge, P. J.*; Tan, D. S.* ChemBioChem 2012, 13, 129–136.
    Abstract | PubMed | PMC ]

  9. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals.
    Wurst, J. M.; Liu, G.; Tan, D. S.* J. Am. Chem. Soc. 2011, 133, 7916–7925.
    Abstract | PubMed | PMC ]

  10. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library.
    Moura-Letts, G.; DiBlasi, C. M.; Bauer, R. A.; Tan, D. S.* Proc. Natl. Acad. Sci. USA 2011, 108, 6745–6750.
    Abstract | PubMed | PMC ]

  11. The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis.
    Bauer, R. A.; DiBlasi, C. M.; Tan, D. S.* Org. Lett. 2010, 12, 2084–2087.
    Abstract | PubMed | PMC ]

  12. Expanding the range of 'druggable' targets with natural product-based libraries: An academic perspective.
    Bauer, R. A.; Wurst, J. M.; Tan, D. S.* Curr. Opin. Chem. Biol. 2010, 14, 308–314.
    Abstract | PubMed | PMC ]

  13. Active site remodelling accompanies thioester bond formation in the SUMO E1.
    Olsen, S. K.; Capili. A. D.; Lu, X.; Tan, D. S.*; Lima, C. D.* Nature 2010, 463, 906–912.
    Abstract | PubMed | PMC ]
    (Highlighted in Nature, Chem. Eng. News, Nat. Rev. Mol. Cell Biol., Nat. Chem. Biol., Structure, ACS Chem. Biol., and Faculty of 1000 Biology )

  14. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes.
    Lu, X.; Olsen, S. K.; Capili, A. D.; Cisar, J. S.; Lima, C. D.*; Tan, D. S.* J. Am. Chem. Soc. 2010, 132, 1748–1749.
    Abstract | PubMed | PMC ]
    (Highlighted in Chem. Eng. News, Nat. Rev. Mol. Cell Biol., ACS Chem. Biol., and Faculty of 1000 Biology )

  15. Stereoselective synthesis of benzannulated spiroketals: Influence of the aromatic ring on reactivity and conformation.
    Liu, G.; Wurst, J. M.; Tan, D. S.* Org. Lett. 2009, 11, 3670–3673.
    Abstract | PubMed | PMC ]

  16. Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis.
    Lu, X.; Zhang, H.; Tonge, P. J.*; Tan, D. S.* Bioorg. Med. Chem. Lett. 2008, 18, 5963–5966.
    Abstract | PubMed | PMC ]

  17. Small molecule inhibition of microbial natural product biosynthesis – An emerging antibiotic strategy.
    Cisar, J. S.; Tan, D. S.* Chem. Soc. Rev. 2008, 37, 1320–1329.
    Abstract | PubMed | PMC ]

  18. Mycobacterial phenolic glycolipid virulence factor biosynthesis: Mechanism and small-molecule inhibition of polyketide chain initiation.
    Ferreras, J. A.; Stirrett, K. L.; Lu, X.; Ryu, J.-S.; Soll, C. E.; Tan, D. S.; Quadri, L. E. N.* Chem. Biol. 2008, 15, 51–61.
    Abstract | PubMed | PMC ]
    (Highlighted in Chem. Biol. )

  19. Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.
    Cisar, J. S.; Ferreras, J. A.; Soni, R. K.; Quadri, L. E. N.*; Tan, D. S.* J. Am. Chem. Soc. 2007, 129, 7752–7753.
    Abstract | PubMed | PMC ]
    (Highlighted in Faculty of 1000 Biology )

  20. A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.
    Shang, S.; Iwadare, H.; Macks, D. E.; Ambrosini, L. M.; Tan, D. S.* Org. Lett. 2007, 9, 1895–1898.
    Abstract | PubMed | PMC ]

  21. Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration.
    Moilanen, S. B.; Potuzak, J. S.; Tan, D. S.* J. Am. Chem. Soc. 2006, 128, 1792–1793.
    Abstract | PubMed | PMC ]
    (Highlighted in Nature )

  22. Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction.
    Potuzak, J. S.; Moilanen, S. B.; Tan, D. S.* J. Am. Chem. Soc. 2005, 127, 13796–13797.
    Abstract | PubMed  ]

  23. Diversity-oriented synthesis: Exploring the intersections between chemistry and biology.
    Tan, D. S.* Nat. Chem. Biol. 2005, 1, 74–84.
    Abstract | PubMed ]

  24. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.
    Ferreras, J. A.; Ryu, J.-S.; Di Lello, F.; Tan, D. S.*, Quadri, L. E. N.* Nat. Chem. Biol. 2005, 1, 29–32.
    Abstract | PubMed ]
    (Highlighted in Nature, Nat. Chem. Biol., Chem. Eng. News., and Mercosur Económico )

  25. Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries.
    Shang, S.; Tan, D. S.* Curr. Opin. Chem. Biol. 2005, 9, 248–258.
    Abstract | PubMed ]

  26. An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis.
    DiBlasi, C. M.; Macks, D. E.; Tan, D. S.* Org. Lett. 2005, 7, 1777–1780.
    Abstract | PubMed ]
    (Highlighted in Lett. Org. Chem. [PDF] )

  27. Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: New insights into glycal reactivity.
    Moilanen, S. B.; Tan, D. S.* Org. Biomol. Chem. 2005, 3, 798–803.
    Abstract | PubMed ]

  28. Current progress in natural product-like libraries for discovery screening.
    Tan, D. S.* Comb. Chem. High-Throughput Screen. 2004, 7, 631–643.
    Abstract | PubMed ]

  29. Synthesis of C1-alkyl and C1-acylglycals from glycals using a B-alkyl Suzuki–Miyaura cross coupling approach.
    Potuzak, J. S.; Tan, D. S.* Tetrahedron Lett. 2004, 45, 1797–1801.
    Abstract ]

  30. Discovery and applications of small molecule probes for studying biological processes.
    Potuzak, J. S.; Moilanen, S. B.; Tan, D. S.* Biotechnol. Genet. Eng. Rev. 2004, 21, 11–78.
    TOC | PDF | PubMed ]

  31. Sweet surrender to chemical genetics.
    Tan, D. S.* Nat. Biotechnol. 2002, 20, 561–563.
    Abstract | PubMed ]

Postdoctoral Publications

  1. Total synthesis of guanacastepene A: A route to enantiomeric control.
    Mandal, M.; Yun, H.; Dudley, G. B.; Lin, S.; Tan, D. S.; Danishefsky, S. J.* J. Org. Chem. 2005, 70, 10619–10637.
    Abstract | PubMed ]
    (Featured on the Cover )

  2. Synthesis of the functionalized tricyclic skeleton of guanacastepene A: A tandem epoxide-opening β-elimination/Knoevenagel cyclization.
    Tan, D. S.; Dudley, G. B; Danishefsky, S. J.* Angew. Chem., Int. Ed. 2002, 41, 2185–2188.
    Abstract | PubMed ]

  3. A stereoselective route to guanacastepene A through a surprising epoxidation.
    Lin, S.; Dudley, G. B.; Tan, D. S.; Danishefsky, S. J.* Angew. Chem., Int. Ed. 2002, 41, 2188–2191.
    Abstract | PubMed ]

  4. Remarkable stereoselectivity in the alkylation of a hydroazulenone: Progress toward the total synthesis of guanacastepene.
    Dudley, G. B.; Tan, D. S.; Kim, G.; Tanski, J. M.; Danishefsky, S. J.* Tetrahedron Lett. 2001, 42, 6789–6791.
    Abstract ]

Graduate Publications

  1. A mercury-catalyzed transetherification cyclization leading to fused cyclic polyethers.
    Tan, D. S.; Schreiber, S. L.* Tetrahedron Lett. 2000, 41, 9509–9513.
    Abstract ]

  2. Ligand discovery using encoded combinatorial libraries.
    Tan, D. S.*; Burbaum, J. J.* Curr. Opin. Drug Discovery Dev. 2000, 3, 439–453.
    Abstract | PubMed ]

  3. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays.
    Tan, D. S.; Foley, M. A.; Stockwell, B. R.; Shair, M. D.; Schreiber, S. L.* J. Am. Chem. Soc. 1999, 121, 9073–9087.
    Abstract ]

  4. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays.
    Tan, D. S.; Foley, M. A.; Shair, M. D.; Schreiber, S. L.* J. Am. Chem. Soc. 1998, 120, 8565–8566.
    Abstract ]
    (Highlighted in Science, Chem. Eng. News. )

Undergraduate Publication

  1. Enzymatic resolution coupled with substrate racemization using a thioester substrate.
    Tan, D. S.; Günter, M. M.; Drueckhammer, D. G.* J. Am. Chem. Soc. 1995, 117, 9093–9094.
    Abstract ]