The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design as complementary approaches to ligand discovery. Our work in both of these areas is influenced at multiple levels by insights from natural products. At the core of these efforts is the development of new chemical methodologies to provide flexible, efficient, systematic access to these structures. We leverage multidisciplinary collaborations with biologists to evaluate these molecules to probe key biological processes and to explore new therapeutic opportunities in cancer and infectious diseases.
Derek Tan, PhD
Chairman and Member, Chemical Biology Program, SKI; Tri-Institutional Professor
Research FocusDerek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.
- BS, Stanford University
- PhD, Harvard University
- Structure-based design, synthesis, and biological evaluation of non-acyl sulfamate inhibitors of the adenylate-forming enzyme MenE.
Evans, C. E.†; Si, Y.†; Matarlo, J. S.; Yin, Y.; French, J. B.; Tonge, P. J.*; Tan, D. S.* Biochemistry 2019, 58, 1918–1930.
[ Abstract | PubMed ]
- Kinetic analyses of the siderophore biosynthesis inhibitor salicyl-AMS and analogues as MbtA inhibitors and antimycobacterial agents.
Bythrow, G. V.; Mohandas, P.; Guney, T.; Standke, L. C.; Germain, G. A.; Lu, X.; Ji, C.; Levendosky, K.; Chavadi, S. S.; Tan, D. S.*; Quadri, L. E. N.* Biochemistry 2019, 883–847.
[ Abstract | PubMed |
- Development of salicyl-AMS, a novel antibacterial agent to treat tuberculosis and other infections
- Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2010)
- Dean's Award for Excellence in Teaching and Mentoring, Weill Cornell Graduate School of Medical Sciences (2013)