Chemical Biology Program

The Derek Tan Lab

Research

Derek Tan, research lab head
Derek Tan, PhD
Chair, Chemical Biology Program, SKI; Tri-Institutional Professor

The identification of small-molecule probes and therapeutic lead compounds to address novel biological targets is a significant current challenge in chemical biology and drug discovery. We are engaged in a two-pronged approach to this problem involving diversity-oriented synthesis and rational design as complementary approaches to ligand discovery. Our work in both of these areas is influenced at multiple levels by insights from natural products. At the core of these efforts is the development of new chemical methodologies to provide flexible, efficient, systematic access to these structures. We leverage multidisciplinary collaborations with biologists to evaluate these molecules to probe key biological processes and to explore new therapeutic opportunities in cancer and infectious diseases. Our group is strongly committed to promoting diversity and inclusion at all levels and welcomes scientists from all backgrounds!

View Lab Overview

Research Projects

Publications

Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes.
Kinarivala, N; Standke, L. C; Guney, T.; Cheng, J.; Naoyoshi, N.; Yasutomi, A.; Tan, D. S.*Method Enzymol. 2020, 638, 69–87.
Abstract | PubMed |PMC ]

Total synthesis of the bacterial diisonitrile chalkophore SF2768.
Xu, Y.; Tan, D. S. Org. Lett. 2019, 8731–8735.
Abstract | PubMed ]

Structural basis for adenylation and thioester bond formation in the ubiquitin E1.
Hann, Z. S.; Ji, C.; Olsen, S. K.; Lu, X.; Lux, M. C.; Tan, D. S. *; Lima, C. D.* Proc. Natl. Acad. Sci. U.S.A. 2019, 15475–15484.
Abstract | PubMed | PMC ]

Synthesis of bicyclic ethers by a palladium-catalyzed oxidative cyclization-redox relay-π-allyl-Pd cyclization cascade reaction.
Lux, M. C.; Boby, M. L.; Brooks, J. L.; Tan, D. S.* Chem. Commun. 2019, 55, 7013–7016.
Abstract | PubMed | PMC ]

Targeting adenylate-forming enzymes with designed sulfonyladenosine inhibitors.
Lux, M. C.; Standke, L. C.; Tan, D. S.* J. Antibiot. 2019, 72, 325–349.
Abstract | PubMed | PMC ]

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People

Derek Tan, research lab head

Derek Tan, PhD

Chair, Chemical Biology Program, SKI; Tri-Institutional Professor

  • Derek Tan’s lab studies diversity-oriented synthesis and rational drug design of probes and lead compounds for chemical biology and drug discovery.
  • BS, Stanford University
  • PhD, Harvard University
tand@mskcc.org
Email Address
646-888-2234
Office Phone
Download CV
PDF File

Members

Derek Tan, PhD
Derek Tan

Member and Lab Head

Kristin Hulsaver, MA
Kristin Hulsaver

Senior Administrative Assistant

Dipti Barman

Research Associate

Melissa  Boby
Melissa Boby

Graduate Student

Farhan Chowdhury
Farhan Chowdhury

Research Assistant

Broderick Corless
Broderick Corless

Pharmacology Graduate Student

Avelyn Delos Reyes

Graduate Student

Jonghan Peter Lee

Graduate Student

Alberto Muñoz
Alberto Muñoz

Postdoctoral Fellow

Lisa Standke
Lisa Standke

Graduate Student

Samantha Stone

Research Assistant

Shibin Zhao, PhD
Shibin Zhao

Postdoctoral Fellow

Lab Alumni
Renato Bauer

Graduate Student

Justin Cisar

Graduate Student

Tony Davis

Graduate Student

Christopher Evans

Graduate Research Assistant

Sirkka Moilanen Stephan

Graduate Student

Justin Potuzak

Graduate Student

Sharanya Rajagopal

Graduate Student

Nihar Kinarivala
Nihar Kinarivala

Postdoctoral Fellow

Shiying Shang

Graduate Student

Christopher Stratton

Graduate Student

Alyssa Verano

Graduate Research Assistant

Michaelyn Lux
Michaelyn Lux

Graduate Student

William Walkowicz

Co-founder & Chief Scientific Officer at Chemitope Glycopeptide, New York, NY

Kyle Planck

Pharmacology Rotation Student

Gianna Stella

TPCB Rotation Student

Kha Nguyen
Kha Nguyen

Undergraduate Research Assistant

Jacqueline Wurst

Graduate Student

Joshua Brooks

Postdoctoral Fellow

Yao Xu , PhD
Yao Xu

Postdoctoral Fellow

Shalini Balakrishnan

Postdoctoral Fellow

Maria Chiriac, PhD
Maria Chiriac

Postdoctoral Fellow

Christine DiBlasi

Postdoctoral Fellow

Corinne Foley

Postdoctoral Fellow

Tezcan Guney, PhD
Tezcan Guney

Postdoctoral Fellow

Jessica  Hurtak, PhD
Jessica Hurtak

Postdoctoral Fellow

Indrajeet Sharma

Postdoctoral Fellow

Cheng Ji

Postdoctoral Fellow

Felix Kopp

Postdoctoral Fellow

Guodong Liu

Postdoctoral Fellow

Xuequan Lu

Postdoctoral Fellow

Daniel Macks

Postdoctoral Fellow

Gustavo Moura-Letts

Postdoctoral Fellow

Debarshi Pratihar

Postdoctoral Fellow

Christina Rotsides

Research Scholar

Jae-Sang Ryu

Postdoctoral Fellow

Daniel Tao

Research Scholar

Todd Wenderski

Postdoctoral Fellow

Kwesi Amoa

Visiting Scientist

Mark Coster

Visiting Scientist (2013)

Hayato Iwadare

Visiting Scientist

Jeffrey Rothman

Visiting Scientist

Kory Byrns

MD Summer Research Student

Chun Tracy Liu

Research Assistant

Steven Pak

Research Assistant

James Rogér

Research Assistant

Marcus Williams
Marcus Williams

Summer Intern

Sean Abbott

Summer Intern

Junia Alsinawi

Summer Intern

Lisa Ambrosini

Summer Intern

Neal Amin

Summer Intern

Susan Xue Bai

Summer Intern

Matthew Boudreau

Summer Intern

Caitlin Conant

Summer Intern

Mikaela DiBello
Mikaela DiBello

Summer Intern

Alice Fok

Summer Intern

Derek Garcia

Summer Intern

Christopher Gerry

Summer Intern

Eun Bin Go

Summer Intern

Emily Lim

Summer Intern

Leon Moskatel

Summer Intern

Nevena Popovic

Summer Intern

Anna Soltys

Summer Intern

Amanda Ramdular

Summer Intern

Allison Rerick

Summer Intern

Campbell Echols

Administrative Assistant

Danielle Rose

Administrative Assistant

Ayo Shanti

Administrative Assistant

Eleanor Allen

Pharmacology Rotation Student

Gil Blum

TPCB Rotation Student

Elliott Brea

MD-PhD Rotation Student

Chan Hee Choi

MD-PhD Rotation Student (2013)

Ethan Chiang

TPCB Rotation Student

Paul Dossa

TPCB Rotation Student

Paolo Esquivel

TPCB Rotation Student

Jarrod French

TPCB Rotation Student

Elizabeth George Cisar

TPCB Rotation Student

Amrita Hazra

TPCB Rotation Student

Jakob Hebert

TPCB Rotation Student

Alexis Jaramillo

TPCB Rotation Student

Rashad Karimov

TPCB Rotation Student

Zeinul Kazhkenov

TPCB Rotation Student

Muris Kobaslija

TPCB Rotation Student

Michael Langberg

GSK Rotation Student

Christina Maksymiuk

Pharm Rotation Student

Jason Morton

TPCB Rotation Student

Pengju Nie, BS
Pengju Nie

Pharmacology Rotation Student

Inish O'Doherty

TPCB Rotation Student

Jeremy Paige

Pharmacology Rotation Student

Nathaniel Park

TPCB Rotation Student

Julie Pickett

Pharmacology Rotation Student

Rudolph Pisa

TPCB Rotation Student

Cristina Santarossa

TPCB Rotation Student

Shi Chen

TPCB Rotation Student (2013)

Kam Siu

TPCB Rotation Student

Adam Rosenzweig

TPCB Rotation Student

Michael Stokes

Pharmacology Rotation Student

Taku Tsukidate

TPCB Rotation Student

Svena Verma
Svena Verma

Pharmacology Rotation Student

John Wallach

MD-PhD Rotation Student

Evelyn Warner, BA
Evelyn Warner

TPCB Rotation Student

Isa Watson
Isa Watson

Pharmacology Rotation Student

Lina Yi

TPCB Rotation Student

Lab Affilations

Achievements

  • Development of salicyl-AMS, a novel antibacterial agent to treat tuberculosis and other infections
  • Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2010)
  • Dean's Award for Excellence in Teaching and Mentoring, Weill Cornell Graduate School of Medical Sciences (2013)

Lab News & Events

Upcoming event

Building Microbial Chemical Factories

This seminar will be conducted by Zoom Webinar.

Open Positions

Career Opportunities

Graduate Students The Tan Laboratory welcomes graduate students interested in organic chemistry and chemical biology research, particularly diversity-oriented synthesis and rational drug design, via the following graduate programs: Tri-Institutional PhD Program in Chemical Biology (TPCB) Tri-Institutional MD-PhD Program Weill Cornell Medical College Pharmacology Program Gerstner Sloan Kettering Graduate Program Rockefeller University Graduate Program Students interested in laboratory rotations should contact Dr.

Apply now

Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Derek Tan discloses the following relationships and financial interests:

  • Adjuvance Technologies
    Intellectual Property Rights
  • Amgen
    Ownership / Equity Interests
  • Biogen Idec
    Ownership / Equity Interests
  • Bristol-Myers Squibb
    Ownership / Equity Interests
  • CVS Caremark Corp
    Ownership / Equity Interests
  • Cerner Corporation
    Ownership / Equity Interests
  • Emerson Collective
    Provision of Services
  • Institute for Research of Barcelona
    Provision of Services
  • Merck & Co Inc.
    Ownership / Equity Interests
  • United Health Group
    Ownership / Equity Interests

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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