Hayato Iwadare, PhD

Visiting Scientist (2005 - 2007)
Hayato Iwadare

Visiting Scientist
Medicinal Chemistry Research Laboratories, Daiichi Sankyo Co., Ltd., Japan

PhD, Tokyo University of Science, 1999

MS, Tokyo University of Science, 1996

BS, Tokyo University of Science, 1994

Japanese Patents: 7

8) Shang, S.; Iwadare, H.; Macks, D. E.; Ambrosini, L. M.; Tan, D. S.* “A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.” Org. Lett. 2007, 9, 1895-1898.

[ Abstract | PDF | Supporting Info | PMC ]
7) Mukaiyama, T.*; Shiina, I.*; Iwadare, H.; Saitoh, M.; Nishimura, T.; Ohkawa, N.; Sakoh, H.; Nishimura, K.; Tani, Y.; Hasegawa, M.; Yamada, K.; Saitoh, K. “Asymmetric total synthesis of Taxol.” Chem. Eur. J. 1999, 5, 121-161.

[ Abstract | PDF ]
6) Mukaiyama, T.*; Shiina, I.*; Iwadare, H.; Sakoh, H.; Tani, Y.; Hasegawa, M.; Saitoh, K. “Asymmetric total synthesis of Taxol.” Proc. Japan Acad., Ser. B. 1997, 73, 95-100.

[ Journal ]
5) Shiiina, I.*; Iwadare, H.; Sakoh, H.; Tani, Y.; Hasegawa, M.; Saitoh, K.; Mukaiyama, T.* “Stereocontrolled synthesis of the BC ring system of Taxol.” Chem. Lett. 1997, 26, 1139-1140.

[ Abstract | PDF ]
4) Yamada, K.; Iwadare, H.; Mukaiyama, T.* “Construction of AB-ring system of taxane framework by A-ring annulation strategy: Synthesis of 1-hydroxy-8,11,11-trimethylbicyclo [5.3.1]undec-7-en-9-one by way of intramolecular aldol cyclization to form the C1-C10 bond.” Chem. Pharmaceut. Bull. 1997, 1898-1905.

[ Journal ]
3) Mukaiyama, T.*; Shiina, I.*; Iwadare, H.; Saitoh, M.; Nishimura, K.; Nishimura, T.; Ohkawa, N.; Sakoh, H.; Saitoh, K. “An asymmetric synthesis of the BC ring system of 8-epitaxoids by way of intramolecular aldol and successive stereoselective methylation reactions.” Chem. Lett. 1996, 25, 483-484.

[ Abstract | PDF ]
2) Shiina, I.*; Iwadare, H.; Saitoh, M.; Ohkawa, N.; Nishimura, T.; Mukaiyama, T.* “An asymmetric synthesis of the fully functionalized AB ring system of 12-demethyltaxol via successive stereoselective allylation and intramolecular aldol reactions.” Chem. Lett. 1995, 24, 781-782.

[ Abstract | PDF ]
1) Mukaiyama, T.*; Shiina, I.*; Kimura, K.; Akiyama, Y.; Iwadare, H. “Synthesis of AB ring model system of Taxol via allylation of 8-membered ring compound and intramolecular aldol condensation.” Chem. Lett. 1995, 24, 229-230.

[ Abstract | PDF ]