Sarat Chandarlapaty, MD, PhD

Slideshow

Figures from the Chandarlapaty Laboratory

My lab focuses on understanding the integration and dysregulation of growth factor signal transduction pathways that are aberrantly activated in the majority of cancers. My current research centers on determining how the PI3K/AKT/mTOR pathway regulates itself and other signaling networks as well as the functional significance of this feedback and cross talk in tumorigenesis and resistance to PI3K/AKT/mTOR directed therapies. Major efforts include identification and characterization of feedback and cross-talk pathways among the different subtypes of breast cancer that feature PI3K/AKT/mTOR activation, determination of the biological significance of the negative feedback pathway in major tumor phenotypes, preclinical and early-phase clinical development of pharmacologic strategies to overcome feedback-mediated resistance to PI3K/AKT/mTOR inhibitors,  and analysis of human tumor samples to more comprehensively understand therapeutic resistance to targeted therapy in breast cancer.