Our laboratory studies tumor-suppressor networks controlling apoptosis and senescence and how their disruption influences malignant behavior.


Chen, C., Liu, Y., Rappaport, A.R.,  Kitzing, T., Schultz, N., Zhao, Z., Shroff, A.S., Dickins, R.A., Vakoc, C.R., Bradner, J.E., Stock, W., Le Beau, M.M., Shannon, K.M., Kogan, S., Zuber, J., and Lowe, S.W. (2014). MLL3 is a a haploinsufficient 7q tumor suppressor in acute myeloid leukemia. Cancer Cell. 2014 May 12;25(5):652-65. doi: 10.1016/j.ccr.2014.03.016. Epub 2014 May 1.  PMID: 24794707. PubMed in Process. NIHMS:NIHMS592990.

Weissmueller, S., Manchado, E., Saborowski, M., Morris IV, J.P., Wagenblast, E., Davis, C.A., Moon, S-H., Pfister, N.T., Tschaharganeh, D.F., Kitzing, T., Aust, D., Markert, E.K., Jianmin, W., Grimmond, S.M., Pilarsky, C., Prives, C.P., Biankin, A.V., and Lowe, S.W. (2014). Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor beta signaling. Cell. 157(2):382-94. PMID: 24725405. PMCID: PMC4001090.

Miething, C., Scuoppo, C., Bosbach, B., Appelmann, I., Nakitandwe, J., Ma, G., Wu, G., Lintault, L., Auer, M., Premsrirut, P., Teruya-Feldstein, J., Hicks, J., Benveniste, H., Speicher, M.R., Downing, J.R. and Lowe, S.W. (2014). PTEN action in leukemia dictated by the tissue microenvironment. Nature. Nature. 2014 May 4. doi: 10.1038/nature13239. [Epub ahead of print] PMID:24805236. PubMed in Process. NIHMS:NIHMS574496.

Lujambio A, Akkari L, Simon J, Grace D, Bolden JE, Zhao Z, Thapar V, Joyce J, Krizhanovsky V, Lowe SW (2013). Non-cell-autonomous tumor suppression by p53. Cell. 153(2):449-60. PMID: 23562644. PMCID: PMC3702034.

Tschaharganeh, D.F., Xue, W., Calvisi, D.F., Evert, M., Michurina, T.V., Dow, L.E., Banito, A., Katz, S.F., Kastenhuber, E.R., Weissmueller, S., Huang, C-H., Lechel, A., Andersen, J.B., Capper, D., Zender, L., Longerich, T., Enikolopov, G., and Lowe, S.W. (2014) p53 dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. Cell. 158(3):579-592. PMID: 25083869.

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Pictured: Scott Lowe

At Work: Cancer Biology and Genetics Program Chair Scott Lowe

Biologist Scott W. Lowe is an expert on the processes that naturally inhibit cancer development.