The major theme of our work is how DNA repair processes are disrupted in human cancers and how this can be exploited therapeutically. The biologically significant DNA damage caused by ionizing radiation and a number of cytotoxic drugs requires double-strand break repair for survival. We have largely focused on the role of double-strand break repair and homologous recombination in particular.

Laboratory phone:
646-888-3064
At Work: Radiation Oncology Department Chair Simon Powell

At Work: Radiation Oncology Department Chair Simon Powell

Radiation oncologist Simon Powell eagerly tackles the challenge of translating discoveries from the laboratory to the clinic as effectively as possible.