Kinetic analysis of human ES cell migration from the SVZ to OB
The lab studies human ES cells as potential tools for cell replacement therapy. Our focus is on neural differentiation and neuronal/glial subtype specification as well as on the interaction of human ES cells with the adult brain environment. Our projects include the study of radiation damage in the brain with emphasis on the fate of stem cells and oligoprogenitors, as well as the possibility of cell replacement as a means of ameliorating cognitive decline. Other translational applications of human ES cells are in neurodegenerative models, such as ALS and Parkinson's disease.