Within Memorial Hospital, many scientists lead research laboratories, including some physician-scientists who apply insights from the clinic to their laboratory work. Our investigators conduct research ranging from analyzing genetic changes in patient tumor samples to developing new imaging techniques to studying the best ways to optimize radiation therapy delivery.
Learn more about our investigators who head basic and translational research laboratories within Memorial Hospital.
Scott A. Armstrong
Physician-scientist Scott Armstrong focuses on defining genetic and epigenetic programs that control the extensive self-renewal properties associated with leukemia and other cancers.
Memorial Sloan-Kettering Physician-in-Chief José Baselga studies mechanisms of resistance to targeted therapies and identification of novel therapeutic combinations in solid cancers.
Michelle S. Bradbury
Clinician-scientist Michelle Bradbury develops translational, tumor-targeting, PET-optical silica nanoparticle probes for diagnostics, drug delivery, and sensing.
Cameron W. Brennan
Physician-scientist Cameron Brennan focuses on genomic analysis of human and mouse gliomas and medulloblastomas.
Renier J. Brentjens
Physician-scientist Renier Brentjens develops novel immunotherapies for leukemias and lymphomas.
Emily H. Cheng
Physician-scientist Emily Cheng focuses on the molecular mechanisms of cell death and their implications in tumorigenesis and cancer therapy, with primary emphasis on lung and kidney cancers.
Nai-Kong V. Cheung
Physician-scientist Nai-Kong Cheung focuses on engineering of antibodies and immune cells to treat solid tumors in children.
Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic transcription factors in GIST and other solid tumors.
Joseph O. Deasy
Medical Physics Department Chair Joseph Deasy focuses on integration and analysis of dose, imaging, and molecular data to predict outcomes and guide personalized treatments.
James A. Fagin
Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.
James J. Hsieh
Physician-scientist James Hsieh focuses on developing novel therapeutics targeting cancer cell proliferation; he also directs Memorial Sloan-Kettering’s translational kidney cancer research program.
Katharine C. Hsu
Physician-scientist Katharine Hsu studies the biology of human natural killer cells and how they contribute to disease processes.
Jason T. Huse
Physician-scientist Jason Huse focuses on the molecular pathogenesis of brain tumors, particularly high-grade gliomas.
Medical physicist Andrew Jackson studies the relationship between radiotherapy dose distributions and treatment outcome and the optimization of radiotherapy treatment planning.
Jason A. Koutcher
Physician-scientist Jason Koutcher studies applications of magnetic resonance spectroscopy and imaging to enhance the therapeutic gain of different antineoplastic modalities.
Ross L. Levine
Physician-scientist Ross Levine focuses on the investigation of genetic basis of hematopoietic malignancies.
Jason S. Lewis
Radiochemist Jason Lewis develops radiopharmaceuticals for the imaging and therapy of cancer.
Gikas S. Mageras
Medical physicist Gikas Mageras focuses on radiation treatment planning and verification using CT images to guide radiation treatment and monitor and correct for patient internal and external movement during treatment delivery.
Christopher Y. Park
Physician-scientist Christopher Park focuses on the identification and characterization of molecular pathways that regulate normal and malignant stem cells in the hematopoietic system.
Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.
Physician-scientist Govind Ragupathi studies tumor vaccinology, including approaches to augmenting the antibody and T cell response to defined cancer antigens.
Optical engineer Milind Rajadhyaksha studies confocal microscopy for the imaging of cancer, technology development, and translational and clinical studies in skin and head and neck cancers.
Imaging specialist Thomas Reiner focuses on the development of novel imaging probes for both PET imaging and optical imaging technologies.
Charles M. Rudin
Physician-scientist Charles Rudin focuses on the development and testing of novel therapeutic approaches to lung cancer in preclinical models.
Physician-scientist Gary Schwartz focuses on the identification of cell-cycle inhibitors that promote chemotherapy-induced apoptosis and their use in cancer therapy.
Physician-scientist Samuel Singer studies the genomic alterations that define new targets for therapy in sarcoma.
Physician-scientist Bhuvanesh Singh focuses on delineating the role of ubiquitination in cancer pathogenesis.
David B. Solit
Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
Physician-scientist Viviane Tabar focuses on in vivo applications of neural derivatives of pluripotent stem cells (such as iPS and ES cells) and on cancer stem cells in human brain tumors.
Sunitha B. Thakur
Medical physicist Sunitha Thakur focuses on MR biomarkers for early detection and monitoring response to treatment.
Wolfgang A. Weber
Physician-scientist Wolfgang Weber specializes in imaging and therapy, with a focus on the translation of novel drugs, imaging agents, and methodologies from bench to bedside.
Martin R. Weiser
Physician-scientist Martin Weiser investigates the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.
Sam S. Yoon
Physician-scientist Sam Yoon studies the role of tumor microenvironment in the progression and radiation response of sarcomas and gastric cancer.
James W. Young
Physician-scientist James Young studies innate and adaptive immunity against tumors and viruses stimulated by human dendritic cells.
Pat B. Zanzonico
Medical physicist Pat Zanzonico fosuses on radionuclide-based methods for detecting and localizing tumor hypoxia, immune effector-cell trafficking, patient-specific dosimetry for radionuclide therapies, and small-animal and molecular imaging.