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Office Phone:646-735-8155
E-mail:bernstej@mskcc.org
Education:Yale University

Jonine Bernstein
Jonine Bernstein, PhD
Associate Attending Epidemiologist

Current Research Interests:

Dr. Bernstein is the PI of the WECARE Study (for Women's Environmental, Cancer, and Radiation Epidemiology) which examines genetic susceptibility and radiation exposure in breast cancer. Current studies are examining mutations in ATM, BRCA1/2, Chek2, 53BPI, MDC1, Rad50, and MRN genes. In addition, Dr. Bernstein has a subcontract to Dr. Patrick Concannon of the University of Virginia on his study examining the functional significance of the ATM variants detected during screening of the WECARE Study population. In addition, Dr. Bernstein and Dr. Sara Olson are collaborating on an NIH-funded multi-center study, the GLIOGENE (Genetic Epidemiology of Glioma) study, to characterize genes in familial glioma cases. Using a genome-wide single-nucleotide polymorphism (SNP) approach and linkage analysis, they will identify new genomic regions or loci that could harbor genes important for gliomagenesis and progression. The MSKCC team joins a large group in North America, Europe, and Israel on this endeavor with Melissa Bondy of MD Anderson as Principal Investigator (Malmer 2007).

Career Opportunities
Open positions for cancer epidemiologists

Selected Bibliography:

  1. Bernstein JL, Thompson W, Risch N, Holford T. Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer.Am J Epidemiol 1992;136:925-36.

  2. Bernstein JL, Thompson W, Risch N, Holford T. Survival following diagnosis of second primary breast cancer. Am J Epidemiol 1993;138:599.

  3. Bernstein JL, Thompson WD, Casey G, DiCioccio RA, Whittemore AS, Diep AT, Thakore SS, Vaziri S, Xue S, Haile RW. Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue. Cancer Epidemiol Biomarkers Prev 2002;11:809-14.

  4. Bernstein JL, Teraoka S, Haile R, Børresen-Dale A, Rosenstein B, Gatti R, Diep A, Jansen L, Atencio D, Olsen J, Bernstein L, Teitelbaum S, Thompson WD, Concannon P, and the WECARE Study Collaborative Group. Designing and implementing quality control for multi-center screening of mutations in the ATM gene among women with breast cancer. Hum Mutat 2003;21:542-550.

  5. Bernstein JL, Langholz BM, Haile RW, Bernstein L, Thomas DC, Stovall M, Malone KE, Lynch CF, Olsen JH, Anton-Culver H, Shore RE, Boice Jr. JD, Berkowitz GS, Gatti RA, Teitelbaum SL, Smith SA, Rosenstein BS, Borresen-Dale A, Concannon P, Thompson WD. Study design: evaluating gene-environment interactions in the etiology of breast cancer - the WECARE Study. Breast Cancer Res 2004; 6:R199-R214.

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