Current Research Interests:
Dr. Ostrovnaya is interested in statistical methods in cancer genomics and proteomics. One of the recent projects she has been working on involves developing methodology for distinguishing second primary tumors from metastases using point mutations or copy number alteration profiles. Other interests include developing new methods for indentifying copy number variations and multiple testing in genomics. Dr. Ostrovnaya is a biostatistician for POETIC (Pediatric Oncology Experimental Therapeutic Consortium) studies. She also collaborates with the high throughput screening lab at MSKCC to identify small molecules or genes that may lead to novel anticancer drugs. Finally, she is working with Dr. Paul Tempst on a study of the reproducibility of serum proteomic data.
Selected Bibliography:
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Waggoner DJ, Raca G, Welch K, Dempsey M, Anderes E, Ostrovnaya I, Alkhateeb A, Kamimura J, Matsumoto N, Schaeffer GB, Martin CL, Das S. NSD1 analysis for Sotos syndrome: insights and perspectives from the clinical laboratory. Genet Med 2005; 7(8):524-33.
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Bufford J, Li Z, Reardon C, Roberg K, Tisler C, Anderson E, DaSilva D, Ostrovnaya I, Hoffjan S, Nicolae D,Gangnon R, Ober C, Lemanske RF, Gern JE. Time-dependent effects of dog exposure and genotype at immune-related genes on wheezing and atopy in early childhood. J Allergy Clin Immunol 2006; 117(2):186.
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Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Integrin beta3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol 2007;119(6):1423-9.
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Ostrovnaya I, Seshan V., Begg CB. Comparison of properties of tests for assessing tumor clonality. Biometrics 2008; 64(4):1018-22.
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Fahy BN, D'Angelica M, DeMatteo RP, Blumgart LH, Weiser MR, Ostrovnaya I, Gonen M, Jarnagin WR. Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention. Ann Surg Oncol. 2009 Feb;16(2):361-70.
