Evan Rosenbaum
Department of Medicine
Project: Developing a Machine-Learning Model to Predict Responses to Immune Checkpoint Blockade in Sarcomas.

Andrew Koff
Molecular Biology Program
Project: Role of Senescence in the Resistance Landscape to CDK4/6i in DDLS.

Asmin Tulpule
Department of Pedatrics
Human Oncology and Pathogenesis Program
Project: Targeting DNA Repair Defects in FET Fusion Sarcomas.

Liang Deng
Department of Medicine
Memorial Hospital Research Laboratories
Project: Activating Neutrophils by Immunogenic Recombinant Modified Vaccinia Viruses for the Treatment of “Immune-Desert” Sarcomas.

Cristina Antonescu
Department of Pathology
Memorial Hospital Research Laboratories
Project: Establish Appropriate Cellular Contexts and Vulnerabilities to Model Sarcoma-Relevant Translocations across Cell Lineages: Exploiting the Gene Fusion Promiscuity as a Common Pathway of Transformation.

Ping Chi
Department of Medicine
Human Oncology and Pathogenesis Program
Project: Understanding and Targeting MYC-Mediated Tumorigenesis and Plasticity in Angiosarcoma

Luis Parada
Cancer Biology and Genetics Program
Project: Cancer Stem Cells in NF1-Associated MPNST

Nai-Kong Cheung
Department of Pediatrics
Memorial Hospital Research Laboratories
Project: CD24xCD3 Bispecific Antibody (BsAb) for Compartmental Immunotherapy and Radioimmunotherapy in Desmoplastic Small Round Cell Tumors

Alex Kentsis
Department of Pediatrics
Molecular Pharmacology Program
Project: Combination Epigenetic Therapies for BAF-Deficient Sarcomas

Sandra D’Angelo
Department of Medicine
Project: The Efficacy of CDK4 Inhibition and Immune Checkpoint Blockade in Locally Advanced, Resectable, and Metastatic Dedifferentiated Liposarcoma — Identifying Senescence and Immune Biomarkers Predictive of Clinical Benefit

Ping Chi
Department of Medicine
Human Oncology and Pathogenesis Program
Project: Immune Evasion and Immunotherapeutic Intervention of PRC2-Deficient Tumors

Aimee Crago
Department of Surgery
Memorial Hospital Research Laboratories
Project: Investigating HIF1A Signaling to Identify Predictive Markers and Therapeutic Targets in Desmoid Tumors

Frederic Geissmann
Immunology Program
Project: Targeting Lung Macrophages in Metastatic Osteosarcoma

Hans-Guido Wendel
Cancer Biology and Genetics Program
Project: Determinants of Escape from Natural Killer Cells in Sarcoma

Andrew Kung
Department of Pediatrics
Project: Optimizing T Cell-Based Immunotherapies for Pediatric Sarcomas and AML

Two sarcoma research projects are being funded as part of this larger project:

Christopher Klebanoff
Department of Medicine
Human Oncology and Pathogenesis Program
Project: TCR Immunotherapy Targeting Shared Neoantigens Derived from Sarcoma-Associated EWSR1-WT1 Oncogenic Gene Fusions

Renier Brentjens
Department of Medicine
Human Oncology and Pathogenesis Program
Project: Axl/EphA2 Dual Targeted CAR T Cells Modified to Secrete the IL-18 Cytokine for the Treatment of Osteosarcoma

Christopher Klebanoff
Department of Medicine
Human Oncology and Pathogenesis Program
Project: Therapeutic Targeting of a Recurrent Fusion-Derived “Public” Neoantigen Expressed by Desmoplastic Small Round Cell Tumors Using T Cell Receptor (TCR) Gene Therapy (renewal)

Edmund Bartlett
Department of Surgery
Project: Assessing the Efficacy of Radiation Therapy Combined with CDK4/6 Inhibition in the Treatment of Retroperitoneal Dedifferentiated Liposarcoma

Fabio Vanoli
Memorial Hospital Research Laboratories
Project: Modeling and Investigating the Pathogenesis of MYOD1 and RAS Mutant Spindle and Embryonal Rhabdomyosarcoma: Two Histotypes with Opposite Clinical Behavior

Christopher Klebanoff
Department of Medicine
Human Oncology and Pathogenesis Program
Project: Therapeutic Targeting of a Recurrent Fusion-Derived “Public” Neoantigen Expressed by Desmoplastic Small Round Cell Tumors Using T Cell Receptor (TCR) Gene Therapy

Christopher Hackett
Department of Medicine
Project: Multi-Armored CAR T Cells for Sarcoma

Evan Rosenbaum
Department of Medicine
Project: A Phase II Study of the Dual Adenosine Receptor Antagonist AB928 with the Anti-PD-1 Antibody Zimberelimab in Patients with Advanced Dedifferentiated Liposarcoma and Undifferentiated Pleomorphic Sarcoma

Jason Chan
Department of Medicine
Cancer Biology and Genetics Program
Project: Dissecting Tumor Heterogeneity in Undifferentiated Pleomorphic Sarcomas

Benjamin Nacev
Department of Medicine
Project: Identifying Chromatin-Pathway Dependencies in FUS-DDIT3 Expressing Myxoid Liposarcoma Using Chemical and Genetic Strategies

Ciara Kelly
Department of Medicine
Project: Development of a Customized, Multi-Modal Treatment Response Assessment Measurement in Gastrointestinal Stromal Tumors 

Sandra D’Angelo
Department of Medicine
Project: CDK4 Inhibition to Trigger Anti-Tumor Immunity and Augment Efficacy of Combined Checkpoint Blockade in Patients with Metastatic Liposarcomas