Colin Begg, PhD

Attending Biostatistician
Office Phone:
646-735-8108
Office Fax:
646-735-0009
E-mail:
beggc@mskcc.org
Education:
University of Glasgow, UK

Current Research Interests

Dr. Begg is interested in cancer epidemiology, health services research, clinical trials, and the statistical methods that support scientific studies in these disciplines. In recent years he has been pursuing the idea that cancer risk can be uniquely informed by studying patients with multiple primary malignancies. Currently his work on this topic is focused on three areas. In the first, he is developing models for estimating the cancer risks of rare genetic variants. In the second area he has been developing statistical techniques for clonality assessment, used to distinguish independent second primary cancers from metastases on the basis of the somatic molecular profiles of the tumors. In the third area of investigation, he is developing methods for using somatic and germ-line profiles of double primary malignancies to make inferences of about the etiologic heterogeneity of tumor sub-types. He collaborates closely with various other members of the department on these projects, notably Drs Bernstein, Capanu, Ostrovnaya and Seshan.

Mutations that cause cancer: A Q&A session with Drs. Marinela Capanu and Colin Begg

Publications by Colin Begg

Selected Publications

  1. Begg CB, Eng KH, Hummer AJ. Statistical tests for clonality. Biometrics 2007; 63:522-530. [PubMed Abstract]
  2. Capanu M, Orlow I, Berwick M, Hummer AJ, Thomas DC, Begg CB. The use of hierarchical models for estimating relative risks of individual genetic variants: an application to a study of melanoma. Statistics in Medicine 2008; 27:1973-1992. [PubMed Abstract]
  3. Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C, Bernstein JL. Variation of breast cancer risk among BRCA1/2 carriers: An investigation by the WECARE Study Group. JAMA 2008; 299:194-201. [PubMed Abstract]
  4. Girard N, Ostrovnaya I, Lau C, Park B, Ladanyi M, Finley D, Deshpande C, Rusch V, Orlow I, Travis WD, Pao W, Begg CB. Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers. Clinical Cancer Research 2009;15:5184-5190. [PubMed Abstract]
  5. Ostrovnaya I, Olshen AB, Seshan VE, Orlow I, Albertson DG, Begg CB. A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data. Statistics in Medicine, in press.