Irina Ostrovnaya

Office Phone:

646-735-8165

E-mail:

ostrovni@mskcc.org

Education:

University of Chicago

Current Research Interests

Dr. Ostrovnaya is interested in statistical methods in cancer genomics and proteomics. One of her recent projects involves developing methodology for distinguishing second primary tumors from metastases using point mutations, copy number or next generation sequencing data. Other interests include developing new methods for prognostic modeling using mutation data. Dr. Ostrovnaya is a biostatistician for neuroblastoma group, POETIC clinical trials (Pediatric Oncology Experimental Therapeutic Consortium) and for the bladder cancer group in the Department of Medicine. She is also working with the lab of Dr. James Hsieh.

Publications by Irina Ostrovnaya

Ostrovnaya, I, Nicolae, DL Estimating the proportion of true null hypotheses under dependence, Statistica Sinica, 2011, in press, doi:10.5705/ss.2010.255.

Gallagher DJ, Al-Ahmadie H, Ostrovnaya I, Gerst SR, Regazzi A, Garcia-Grossman I, Riches J, Gounder SK, Flaherty AM, Trout A, Milowsky MI, Bajorin DF. Sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response. Eur Urol. 2011 Aug;60(2):344-9.

Iasonos A, Ostrovnaya, I. Estimating the dose-toxicity curve in completed phase I studies. Stat Med. 2011, 2011 Jul 30;30(17):2117-29.

Ostrovnaya I, Seshan VE, Olshen A, Begg CB. Clonality: an R package for testing clonal relatedness of two tumors from the same patient based on their genomic profiles. Bioinformatics. 2011;27(12):1698-9. [PubMed Abstract]

Ostrovnaya I, Nanjangud G Olshen A. A classification model for distinguishing copy number variants from cancer-related alterations. BMC Bioinformatics. 2010;11:297. [PubMed Abstract]

Full List of Publications

Cheung NK, Cheung IY, Ostrovnaya I, Kushner BH “Reply to L. Moreno et al.”, J Clin Oncol. 2013 Feb 10;31(5):650-1
Apolo AB, Ostrovnaya I, Halabi S, Iasonos A, Philips GK, Rosenberg JE, Riches J,E Small EJ, Milowsky M, Bajorin DF ”Prognostic model for predicting survival of patients with metastatic urothelial cancer treated with cisplatin-based chemotherapy”, J Natl Cancer Inst, 2013 Feb 14. [Epub ahead of print] [PubMed Abstract]
Balar A, Apolo A, Ostrovnaya I, Mironov S, Iasonos A, Trout A, Regazzi AM, Garcia-Grossman IR, Gallagher DJ, Milowsky MI, and Bajorin DF, ”Phase II Study of Gemcitabine, Carboplatin,and Bevacizumab in Patients with Advanced Unresectable or Metastatic Urothelial Cancer”, JCO, 2013 Jan 22 [Epub ahead of print] [PubMed Abstract]
Kobos R, Nagai M, Tsuda M, Merl MY, Saito T, Laé M, Mo Q, Olshen A, Lianoglou S, Leslie C, Ostrovnaya I, Antczak C, Djaballah H, Ladanyi M “`Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein”', J Pathol. 2013 Jan 3. doi: 10.1002/path.4158
Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, Solit DB, ”Genome Sequencing Identifies a Basis for Everolimus Sensitivity”, Science, 2012 Aug 23 [Epub ahead of print]
Cheung NKV, Cheung IY, Kushner BH, Ostrovnaya I, Kramer K, Modak S, ”Murine Anti-GD2 Monoclonal Antibody 3F8 combined with Granulocyte- Macrophage Colony Stimulating Factor and 13-Cis-Retinoic Acid is Effective against Chemoresistant Marrow MRD among High-Risk Patients with Stage 4 Neuroblastoma in First Remission”, J Clin Oncol. 2012 Aug 6. [Epub ahead of print]
Andrade VP, Ostrovnaya I, Seshan VE, Morrogh M, Giri D, Olvera N, De Brot M, Morrow M, Begg C and King T, ”Clonal Relatedness Between Lobular Carcinoma In Situ and Synchronous Malignant Lesions”, Breast Cancer Research, 2012 July 9;14(4):R103.
Ostrovnaya I. ”Testing clonality of three and more tumors using their loss of heterozygosity profiles”, Statistical Applications in Genetics and Molecular Biology, 2012 July, Volume 11, Issue 4, Pages , ISSN (Online) 1544-6115, DOI: 10.1515/1544-6115.1757
Ostrovnaya I, Nicolae DL. Estimating the proportion of true null hypotheses under dependence. Statistica Sinica. 2012 doi:10.5705/ss.2010.255
Gallagher DJ, Al-Ahmadie H, Ostrovnaya I, Gerst SR, Regazzi A, Garcia-Grossman I, Riches J, Gounder SK, Flaherty AM, Trout A, Milowsky MI, Bajorin DF. Sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response. Eur Urol. 2011;60(2):344-9. [PubMed Abstract]
Iasonos A, Ostrovnaya, I. Estimating the dose-toxicity curve in completed phase I studies. Stat Med. 2011;30(17):2117-29. [PubMed Abstract]
Ostrovnaya I, Seshan VE, Olshen A, Begg CB. Clonality: an R package for testing clonal relatedness of two tumors from the same patient based on their genomic profiles. Bioinformatics. 2011;27(12):1698-9. [PubMed Abstract]
Ostrovnaya I, Nanjangud G Olshen A. A classification model for distinguishing copy number variants from cancer-related alterations. BMC Bioinformatics. 2010;11:297. [PubMed Abstract]
Ostrovnaya I, Olshen A, Seshan V E, Orlow I, Albertson DG, Begg CB. A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data. Stat Med. 2010;29(15):1608-21.
Ostrovnaya I, Begg CB. Testing clonal relatedness of tumors using array comparative genomic hybridization: a statistical challenge. Clin Cancer Res. 2010;16(5):1358-67. [PubMed Abstract]
Girard N, Ostrovnaya I, Lau C, Park B, Ladanyi M, Finley D, Deshpande C, Rusch V, Orlow I, Travis WD, Pao W, Begg CB. Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers. Clin Cancer Res. 2009;15(16):5184-90. [PubMed Abstract]
Orlow I, Tommasi D, Bloom B, Ostrovnaya I, Cotignola J, Mujumdar U, Busam K J, Jungbluth AA, Scolyer RA, Thompson JF, Armstrong BK, Berwick M, Thomas N, Begg CB. Evaluation of the clonal origin of multiple primary melanomas using molecular profiling. J Invest Dermatol. 2009;129(8):1972-82. [PubMed Abstract]
Fahy BN, D'Angelica M, DeMatteo RP, Blumgart LH, Weiser MR, Ostrovnaya I, Gonen M, Jarnagin WR. Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention. Ann Surg Oncol. 2009;16(2):361-70.
Ostrovnaya I, Seshan V, Begg CB. Comparison of properties of tests for assessing tumor clonality. Biometrics. 2008;64(4):1018-22. [PubMed Abstract]
Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Integrin beta3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007;119(6):1423-9.
Bufford J, Li Z, Reardon C, Roberg K, Tisler C, Anderson E, DaSilva D, Ostrovnaya I, Hoffjan S, Nicolae D,Gangnon R, Ober C, Lemanske RF, Gern JE. Time-dependent effects of dog exposure and genotype at immune-related genes on wheezing and atopy in early childhood. J Allergy Clin Immunol. 2006;117(2):186.
Waggoner DJ, Raca G, Welch K, Dempsey M, Anderes E, Ostrovnaya I, Alkhateeb A, Kamimura J, Matsumoto N, Schaeffer GB, Martin CL, Das S. NSD1 analysis for Sotos syndrome: insights and perspectives from the clinical laboratory. Genet Med. 2005;7(8):524-33.
Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel D, Steiner L, Walker K, Shult P, Gangnon R, Gern J, Martinez F, Lemanske R, Ober C. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet. 2005;76(4): 696-704. [PubMed Abstract]
Hoffjan S, Ostrovnaya I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF Jr, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol. 2004;113(3):511-8.

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