Irina Ostrovnaya - Staff Member | Memorial Sloan-Kettering Cancer Center

Office Phone:

646-735-8165

E-mail:

ostrovni@mskcc.org

Education:

University of Chicago

Current Research Interests

Dr. Ostrovnaya is interested in statistical methods in cancer genomics and proteomics. One of her recent projects involves developing methodology for distinguishing second primary tumors from metastases using point mutations or copy number alteration profiles. Other interests include developing new methods for indentifying copy number variations and multiple testing in genomics. Dr. Ostrovnaya is a biostatistician for POETIC clinical trials (Pediatric Oncology Experimental Therapeutic Consortium) and for the bladder cancer group in the Department of Medicine. She also collaborates with the high throughput screening laboratory to identify small molecules or genes that may lead to novel anticancer drugs. Finally, she is working with Dr. Paul Tempst on a study of the reproducibility of serum proteomic data.

Publications by Irina Ostrovnaya

Selected Bibliography

Waggoner DJ, Raca G, Welch K, Dempsey M, Anderes E, Ostrovnaya I, Alkhateeb A, Kamimura J, Matsumoto N, Schaeffer GB, Martin CL, Das S. NSD1 analysis for Sotos syndrome: insights and perspectives from the clinical laboratory. Genet Med 2005; 7(8):524-33.

Bufford J, Li Z, Reardon C, Roberg K, Tisler C, Anderson E, DaSilva D, Ostrovnaya I, Hoffjan S, Nicolae D,Gangnon R, Ober C, Lemanske RF, Gern JE. Time-dependent effects of dog exposure and genotype at immune-related genes on wheezing and atopy in early childhood. J Allergy Clin Immunol 2006; 117(2):186.

Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Integrin beta3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol 2007;119(6):1423-9.

Ostrovnaya I, Seshan V., Begg CB. Comparison of properties of tests for assessing tumor clonality. Biometrics 2008; 64(4):1018-22.

Fahy BN, D'Angelica M, DeMatteo RP, Blumgart LH, Weiser MR, Ostrovnaya I, Gonen M, Jarnagin WR. Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention. Ann Surg Oncol. 2009 Feb;16(2):361-70.

Full List of Publications

Ostrovnaya, I, Nicolae, DL Estimating the proportion of true null hypotheses under dependence, Statistica Sinica, 2011, in press, doi:10.5705/ss.2010.255
Gallagher DJ, Al-Ahmadie H, Ostrovnaya I, Gerst SR, Regazzi A, Garcia-Grossman I, Riches J, Gounder SK, Flaherty AM, Trout A, Milowsky MI, Bajorin DF. Sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response. Eur Urol. 2011 Aug;60(2):344-9
Iasonos A, Ostrovnaya, I. Estimating the dose-toxicity curve in completed phase I studies. Stat Med. 2011, 2011 Jul 30;30(17):2117-29
Ostrovnaya I, Seshan VE, Olshen A, Begg CB. Clonality: an R package for testing clonal relatedness of two tumors from the same patient based on their genomic profiles. Bioinformatics. 2011;27(12):1698-9. PMCID: PMC3106202
Ostrovnaya I, Nanjangud G Olshen A. A classification model for distinguishing copy number variants from cancer-related alterations. BMC Bioinformatics. 2010;11:297. PMCID: PMC2897829
Ostrovnaya I, Olshen A, Seshan V E, Orlow I, Albertson DG, Begg CB. A metastasis or a second independent cancer? Evaluating the clonal origin of tumors using array copy number data. Stat Med. 2010;29(15):1608-21.
Ostrovnaya I, Begg CB. Testing clonal relatedness of tumors using array comparative genomic hybridization: a statistical challenge. Clin Cancer Res. 2010;16(5):1358-67. PMCID: PMC2831112
Girard N, Ostrovnaya I, Lau C, Park B, Ladanyi M, Finley D, Deshpande C, Rusch V, Orlow I, Travis WD, Pao W, Begg CB. Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers. Clin Cancer Res. 2009;15(16):5184-90. PMCID: PMC2892178
Orlow I, Tommasi D, Bloom B, Ostrovnaya I, Cotignola J, Mujumdar U, Busam K J, Jungbluth AA, Scolyer RA, Thompson JF, Armstrong BK, Berwick M, Thomas N, Begg CB. Evaluation of the clonal origin of multiple primary melanomas using molecular profiling. J Invest Dermatol. 2009;129(8):1972-82. PMCID: PMC2745834
Fahy BN, D'Angelica M, DeMatteo RP, Blumgart LH, Weiser MR, Ostrovnaya I, Gonen M, Jarnagin WR. Synchronous hepatic metastases from colon cancer: changing treatment strategies and results of surgical intervention. Ann Surg Oncol. 2009;16(2):361-70.
Ostrovnaya I, Seshan V, Begg CB. Comparison of properties of tests for assessing tumor clonality. Biometrics. 2008;64(4):1018-22. PMCID: PMC2761024
Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Integrin beta3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol. 2007;119(6):1423-9.
Bufford J, Li Z, Reardon C, Roberg K, Tisler C, Anderson E, DaSilva D, Ostrovnaya I, Hoffjan S, Nicolae D,Gangnon R, Ober C, Lemanske RF, Gern JE. Time-dependent effects of dog exposure and genotype at immune-related genes on wheezing and atopy in early childhood. J Allergy Clin Immunol. 2006;117(2):186.
Waggoner DJ, Raca G, Welch K, Dempsey M, Anderes E, Ostrovnaya I, Alkhateeb A, Kamimura J, Matsumoto N, Schaeffer GB, Martin CL, Das S. NSD1 analysis for Sotos syndrome: insights and perspectives from the clinical laboratory. Genet Med. 2005;7(8):524-33.
Hoffjan S, Nicolae D, Ostrovnaya I, Roberg K, Evans M, Mirel D, Steiner L, Walker K, Shult P, Gangnon R, Gern J, Martinez F, Lemanske R, Ober C. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Am J Hum Genet. 2005;76(4): 696-704. PMCID: PMC1199307
Hoffjan S, Ostrovnaya I, Nicolae D, Newman DL, Nicolae R, Gangnon R, Steiner L, Walker K, Reynolds R, Greene D, Mirel D, Gern JE, Lemanske RF Jr, Ober C. Genetic variation in immunoregulatory pathways and atopic phenotypes in infancy. J Allergy Clin Immunol. 2004;113(3):511-8.

Topics Recommended by Irina Ostrovnaya

Biostatistics: Discussion of Predicting False Discovery Proportion Under Dependence

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Irina Ostrovnaya, PhD

Current Research Interests

Selected Bibliography

About Our Research

Research Programs & Departments

Research Resources

Pre- and Postdoctoral Training

Career Opportunities

About Memorial
Sloan-Kettering

Irina Ostrovnaya, PhD

Current Research Interests

Selected Bibliography

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About MemorialSloan-Kettering

About Memorial
Sloan-Kettering