Irina Ostrovnaya, PhD

Assistant Attending Biostatistician
Office Phone:
University of Chicago

Current Research Interests

Dr. Ostrovnaya is interested in statistical methods in cancer genomics and proteomics. One of her recent projects involves developing methodology for distinguishing second primary tumors from metastases using point mutations, copy number or next generation sequencing data. Other interests include developing new methods for prognostic modeling using mutation data. Dr. Ostrovnaya is a biostatistician for neuroblastoma group, POETIC clinical trials (Pediatric Oncology Experimental Therapeutic Consortium) and for the bladder cancer group in the Department of Medicine. She is also working with the lab of Dr. James Hsieh.

Publications by Irina Ostrovnaya

Ostrovnaya, I, Nicolae, DL Estimating the proportion of true null hypotheses under dependence, Statistica Sinica, 2011, in press, doi:10.5705/ss.2010.255.

Gallagher DJ, Al-Ahmadie H, Ostrovnaya I, Gerst SR, Regazzi A, Garcia-Grossman I, Riches J, Gounder SK, Flaherty AM, Trout A, Milowsky MI, Bajorin DF. Sunitinib in urothelial cancer: clinical, pharmacokinetic, and immunohistochemical study of predictors of response. Eur Urol. 2011 Aug;60(2):344-9.

Iasonos A, Ostrovnaya, I. Estimating the dose-toxicity curve in completed phase I studies. Stat Med. 2011, 2011 Jul 30;30(17):2117-29.

Ostrovnaya I, Seshan VE, Olshen A, Begg CB. Clonality: an R package for testing clonal relatedness of two tumors from the same patient based on their genomic profiles. Bioinformatics. 2011;27(12):1698-9. [PubMed Abstract]

Ostrovnaya I, Nanjangud G Olshen A.  A classification model for distinguishing copy number variants from cancer-related alterations. BMC Bioinformatics. 2010;11:297. [PubMed Abstract]