Li-Xuan Qin

Office Phone:

646-735-8116

Office Fax:

646-735-0010

E-mail:

qinl@mskcc.org

Education:

University of Washington

Current Research Interests

Postdoctoral Position We are seeking a motivated individual for a postdoctoral position in the Department of Epidemiology and Biostatistics. Learn more »

Dr. Qin’s research focuses on statistical methods for genomics data in the context of translational cancer research. She is the recipient of an NIH R01 grant to develop efficient statistical methods for normalizing microRNA microarrays. Dr. Qin collaborates closely with the soft tissue sarcoma group on the analysis of clinical and genomic data, as well as the design of clinical trials with a phase II emphasis. She is the Co-Director of the Biostatistics and Bioinformatics Core in the Soft Tissue Sarcoma SPORE.

Publications by Li-Xuan Qin

Qin LX and Satagopan J. Normalization method for transcriptional studies of heterogeneous samples - simultaneous array normalization and identification of equivalent expression. Statistical Applications in Genetics and Molecular Biology 2009, 8: Article 10. [PubMed Abstract]

Qin LX. An Integrative Analysis of microRNA and mRNA Expression - A Case Study. Cancer Informatics 2008, 6:369-379. [PubMed Abstract]

Qin LX and Self SG. The clustering of regression models method with applications to gene expression data. Biometrics 2006, 62: 526-533. [PubMed Abstract]

Qin LX, Beyer R, Hudson N, Linford N, Morris D, Kerr KF. Validation of data transformation methods for oligonucleotide arrays with qRT-PCR measurements. BMC Bioinformatics 2006, 7:23. [PubMed Abstract]

Qin LX, Kerr KF, Contributing Members of the Toxicogenomics Research Consortium. Empirical evaluation of data transformations and ranking statistics for microarray analysis. Nucleic Acids Research 2004, 32(18):5471-5479. [PubMed Abstract]

Full List of Publications

Qin L, Marrs G, McKim R, Dailey M. Hippocampal mossy fibers induce assembly and clustering of PSD95-containing postsynaptic densities independent of glutamate receptor activation. The Journal of Comparative Neurology 2001, 440:284-298.[PubMed Abstract]
Qin LX, Kerr KF, Contributing Members of the Toxicogenomics Research Consortium. Empirical evaluation of data transformations and ranking statistics for microarray analysis. Nucleic Acids Research 2004, 32:5471-5479.[PubMed Abstract]
Members of the Toxicogenomics Research Consortium. Standardizing global gene expression analysis between laboratories and across platforms. Nature Methods 2005, 2:351-356. [PubMed Abstract]
Qin LX, Beyer R, Hudson N, Linford N, Morris D, Kerr KF. Evaluation of methods for oligonucleotide array data via quantitative real-time PCR. BMC Bioinformatics 2006, 7:23.[PubMed Abstract]
Qin LX and Self SG. The clustering of regression models method with applications to gene expression data. Biometrics 2006, 62: 526-533.[PubMed Abstract]
Canter RJ, Qin LX, Downey R, Brennan MF, Singer S, Maki RG. Perioperative chemotherapy in patients undergoing pulmonary resection for metastasis soft tissue sarcoma of the extremity. Cancer 2007, 110:2050-2060. [PubMed Abstract]
Qin LX. An Integrative Analysis of microRNA and mRNA Expression - A Case Study. Cancer Informatics 2008, 6:369-379. [PubMed Abstract]
Al-Ahmadie HA, Alden D, Qin LX, Olgac S, Fine SW, Gopalan A, Russo P, Motzer RJ, Reuter VE, Tickoo SK. Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing two antibodies. American Journal of Surgical Pathology 2008, 32:377-382. [PubMed Abstract]
Forslund A, Zeng A, Qin LX, Rosenberg S, Ndubuisi M, Pincas H, Gerald W, Notterman D, Barany F, Paty PB. MDM2 gene amplification is correlated to tumor progression but not to presence of SNP309 or TP53 mutational status in primary colorectal cancers. Molecular Cancer Research 2008, 6:205-211.[PubMed Abstract]
Ambrosini G, Seelman SL, Qin LX, Schwartz GK. The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. Cancer Research 2008, 68:2312-2320.[PubMed Abstract]
The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 2008, 455:1061-1068.[PubMed Abstract]
Canter RJ, Qin LX, Moraco N, Dalal KM, Maki RG, Brennan MF, Ladanyi M, Singer S. A synovial sarcoma specific preoperative nomogram supports a survival benefit to Ifosfamide-based chemotherapy and improves risk stratification for patients. Clinical Cancer Research 2008, 14:8191-8197.[PubMed Abstract]
Canter RJ, Qin LX, Ferrone CR, Maki RG, Singer S, Brennan MF. Why do patients with low grade sarcoma die? Annals of Surgical Oncology 2008, 15:3550-3560.[PubMed Abstract]
Meng RD, Shelton CC, Li YM, Qin LX, Notterman D, Paty PB, Schwartz GK. Gamma-secretase inhibitors abrogate Oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Research 2009, 69:573-582.[PubMed Abstract]
Kushner BH, Kramer K, Modak S, Qin LX, Yataghena K, Jhanwar SC, and Cheung NKV. Reduced risk of secondary leukemia with fewer cycles of dose-intensive induction chemotherapy in patients with neuroblastoma. Pediatric Blood & Cancer 2009, 53:17-22.[PubMed Abstract]
Qin LX and Satagopan J. Normalization method for transcriptional studies of heterogeneous samples - simultaneous array normalization and identification of equivalent expression. Statistical Applications in Genetics and Molecular Biology 2009, 8: Article 10.[PubMed Abstract]
Jhawer M, Coit D, Brennan M, Qin LX, Gonen M, Klimstra D, Tang L, Kelsen DP, Shah MA. Perineural invasion following preoperative chemotherapy predicts poor survival in patients with locally advanced gastric cancer: gene expression analysis with pathologic validation. American Journal of Clinical Oncology. [PubMed Abstract]
Maki RG, D'Adamo DR, Keohan ML, Saulle M, Schuetze SM, Undevia SD, Livingston MB, Cooney MM, Hensley ML, Mita MM, Takimoto CH, Kraft AS, Elias AD, Brockstein B, Blachère NE, Edgar MA, Schwartz LH, Qin LX, Antonescu CR, Schwartz GK. A phase II study of sorafenib in patients with metastatic or recurrent sarcomas. Journal of Clinical Oncology. [PubMed Abstract]
Li L, Lu Y, Qin LX, Bar-Joseph Z, Werner-Washburne M, Breeden LL. Budding yeast SSD1-V regulates transcript levels of many longevity genes and extends chronological life span in purified quiescent cells. Molecular Biology of the Cell 2009, 20:3851-3864. [PubMed Abstract]
Antonescu CR, Yoshida A, Guo T, Chang NE, Zhang L, Agaram NP, Qin LX, Brennan MF, Singer S, Maki RG. KDR activating mutations in human angiosarcomas are sensitive to specific kinase inhibitors. Cancer Research. 2009, 69:7175-7179.
Korkola JE, Houldsworth J, Feldman DR, Olshen AB, Qin LX, Patil S, Reuter VE, Bosl GJ, Chaganti RS. Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors. Journal of Clinical Oncology 2009, 27:5240-5247.
Allen PJ, Qin LX, Tang L, Klimstra D, Brennan MF, Lokshin A. Pancreatic cyst fluid protein expression profiling for discriminating between serous cystadenoma and intraductal papillary mucinous neoplasm. Annals of Surgery 2009, 250:754-760.
Gershon TR, Shirazi A, Qin LX, Gerald WL, Kenney AM, Cheung NK. Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis. PLoS One 2009, 4:e7491.
Park JO, Qin LX, Prete FP, Antonescu C, Brennan MF, Singer S. Predicting outcome by growth rate of locally recurrent retroperitoneal liposarcoma: the one centimeter per month rule. Annals of Surgery 2009, 250:977-982.
Gladdy RA, Qin LX, Moraco N, Edgar MA, Antonescu CR, Alektiar KM, Brennan MF, Singer S. Do radiation-associated soft tissue sarcomas have the same prognosis as sporadic soft tissue sarcomas? Journal of Clinical Oncology 2010, 28:2064-2069.
Kushner BH, Kramer K, Modak S, Qin LX, Cheung NK. Differential impact of high-dose cyclophosphamide, topotecan, and vincristine in clinical subsets of patients with chemoresistant neuroblastoma. Cancer 2010, 116:3054-3060.
Esemuede I, Forslund A, Khan SA, Qin LX, Gimbel MI, Nash GM, Zeng Z, Rosenberg S, Shia J, Barany F, Paty PB. Improved testing for microsatellite instability in colorectal cancer using a simplified 3-marker assay. Annals of Surgical Oncology 2010, 17:3370-3378.
Fields RC, Hameed M, Qin LX, Moraco N, Jia X, Maki RG, Singer S, Brennan MF. Dermatofibrosarcoma protuberans (DFSP): Predictors of recurrence and the use of systemic therapy. Annals of Surgical Oncology 2011, 18:328-336.
Maker AV, Katabi N, Qin LX, Klimstra DS, Schattner M, Brennan MF, Jarnagin WR, Allen PJ. Cyst fluid interleukin-1b levels predict the risk of carcinoma in intraductal papillary mucinous neoplasms of the pancreas. Clinical Cancer Research 2011, 17:1502-1508.
Gobble RM, Qin LX, Brill ER, Angeles CV, Ugras S, O'Connor RB, Moraco NH, Decarolis PL, Antonescu CR, Singer S. Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis. Cancer Research 2011, 71:2697-2705.
Shih KK, Qin LX, Tanner EJ, Zhou Q, Bisogna M, Dao F, Olvera N, Viale A, Barakat RR, Levine DA. A microRNA survival signature (MiSS) for advanced ovarian cancer. Gynecological Oncology 2011, 121:444-450.
Chen J, Guo T, Zhang L, Qin LX, Singer S, Maki RG, Taguchi T, Dematteo R, Besmer P, Antonescu CR. CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers. Genes Chromosomes & Cancer 2012, 51:186-195.
Morrogh M, Andrade VP, Patil AJ, Qin LX, Mo Q, Sakr R, Arroyo CD, Brogi E, Morrow M, King TA. Differentially expressed genes in window trials are influenced by the wound-healing process: lessons learned from a pilot study with Anastrozole. Journal of Surgical Research 2011, Epub ahead of print.
Morrogh M, Andrade VP, Giri D, Sakr RA, Paik W, Qin LX, Arroyo CD, Brogi E, Morrow M, King TA. Cadherin-catenin complex dissociation in lobular neoplasia of the breast. Breast Cancer Research and Treatment 2011, Epub ahead of print.
Cahlon O, Brennan MF, Jia X, Qin LX, Singer S, Alektiar KM. A Postoperative Nomogram for Local Recurrence Risk in Extremity Soft Tissue Sarcomas After Limb-Sparing Surgery Without Adjuvant Radiation. Annals of Surgery 2011, Epub ahead of print.

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