Jonine Bernstein, PhD

Attending Epidemiologist, Co-Program Leader Survivorship, Outcomes and Risk Program
Office Phone:
646-735-8155
Education:
Yale University

Current Research Interests

Dr. Bernstein is the Principal Investigator (PI) of the WECARE Study (Women’s Environmental, Cancer, and Radiation Epidemiology) which examines genetic susceptibility and radiation exposure in breast cancer. Current investigations involving this resource include studies of the roles of mutations in the ATM, BRCA1, BRCA2 , Chek2, TP53BPI, MDC1, Rad50, and MRN genes.  Recently, Dr. Bernstein was awarded a grant from NIH to conduct a multi-stage genome-wide association study (GWAS) which involves genome-wide screening of the existing WECARE Study cases and controls, and recruitment of a validation data set, in order to discover single-nucleotide polymorphism (SNPs) associated with second primary breast cancer and with radiation. This year the investigators have finished the screening and are currently involved in analyzing the results.  

In 2012,  Dr. Bernstein  received a grant award to  examine the role of  mammographic density as a risk factor  for contralateral breast cancer. In addition, Dr. Bernstein and Dr. Sara Olson are collaborating on an NIH-funded multi-center study, the GLIOGENE (Genetic Epidemiology of Glioma) Study, to characterize genes in familial and sporadic glioma cases. The Memorial Sloan Kettering team joins a large group in North America, Europe, and Israel on this endeavor with Melissa Bondy of MD Anderson as Principal Investigator.  Lastly Dr. Bernstein, along with Drs. Jennifer Brooks and Malcolm Pike, are working with Dr. Elizabeth Morris and other clinical colleagues examining background parenchymal enhancement (BPE) as seen on MRI as a biomarker of breast cancer risk. Dr. Bernstein serves as a member of the board of the American College of Epidemiology (ACE), the National Council on Radiation Protection and Measurement (NCRP),  the NCI Board of Scientific Counselors (BSC), the AACR Molecular Epidemiolgoy (MEG) Steering Committee,  and a member of the American Epidemiological Society (AES). In 2011, she was co-Chair of the Third North American Congress of Epidemiology which occurs every 5 years and is compromised of over 25 participating epidemiology societies. .

Publications by Jonine Bernstein

Bernstein JL, Haile RW, Stovall M, Boice JD Jr, Shore RE, Langholz B, Thomas DC, Bernstein L, Lynch CF, Olsen JH, Malone KE, Mellemkjaer L, Borresen-Dale AL, Rosenstein BS, Teraoka SN, Diep AT, Smith SA, Capanu M, Reiner AS, Liang X, Gatti RA, Concannon P, The WECARE Study Collaborative Group. Radiation exposure, the ATM Gene, and contralateral breast cancer in the women's environmental cancer and radiation epidemiology study. J Natl Cancer Inst 2010; 102(7):475-483.

Malone KE, Begg CB, Haile RW, Borg A, Concannon P, Tellhed L, Xue S, Teraoka S, Bernstein L, Capanu M, Reiner AS, Riedel ER, Thomas DC, Mellemkjaer L, Lynch CF, Boice JD Jr, Anton-Culver H, Bernstein JL. Population-based study of the risk of second primary contralateral breast cancer associated with carrying a mutation in BRCA1 or BRCA2. J Clin Oncol 2010; 28(14):2404-2410.

Reiner AS, John E, Brooks JD, Lynch CF, Bernstein L, Mellemkjær L, Malone KE, Knight JA, Capanu M, Teraoka SN, Concannon P, Liang X, Figueiredo JC, Smith SA, Stovall M, Pike MC,  Haile RW, Thomas DC, Begg CB, The WECARE Study Collaborative Group, Bernstein JL. Risk of asynchronous contralateral breast cancer in non-carriers of BRCA1 and BRCA2 mutations with a family history of breast cancer: A report from the WECARE Study. J Clin Oncol 2013; 31(4):433-9.

Bernstein JL,  Thomas DC, Shore R, Robson ME, Boice J, Stovall M, Andersson M, Bernstein L, Malone K, Reiner AS, Lynch C, Capanu M, Smith SA, Tellhed L, Teraoka SN, Begg CB, Olsen J, Mellemkjaer L, Liang X, Diep A, Borg A, Concannon P, Haile RW, The WECARE Study Collaborative Group. Contralateral Breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: A WECARE Study report. Eur J Cancer 2013. [In Press]