Human Oncology & Pathogenesis Program

Our teams of physician-scientists are working to translate molecular insights into new treatments for cancer.

Physician-scientist David Solit focuses on the development of cancer therapies that target pathways responsible for cancer initiation and progression.

Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.

Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic transcription factors in GIST and other solid tumors.

Physician-scientist Sarat Chandarlapaty studies the regulation of growth factor signaling networks in cancer.

Browse our lab heads

HOPP Year in Review

One of the goals of the Human Oncology and Pathogenesis Program (HOPP) is to achieve progress in various areas of cancer research. In our 2011 Year in Review, learn about our collaborations, innovations, and training that have had an impact on Memorial Sloan-Kettering and its patients.

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Charles Sawyers Discusses New Report about Cancer Progress and Challenges

Memorial Sloan-Kettering physician-scientist Charles Sawyers, who serves as president of the American Association for Cancer Research, highlights findings from the group’s new report.

Pictured:  Timothy Chan
Investigators Sequence the Genome of a Rare Head and Neck Cancer

Investigators have sequenced the genome of adenoid cystic carcinoma, a rare and deadly head and neck cancer. The work sets the stage for the sequencing of additional rare cancers at Memorial Sloan-Kettering.

Pictured: Timothy Chan
Pictured: Scott Lowe & Zhen Zhao
A Look Inside the Geoffrey Beene Cancer Research Center

Watch our scientists discuss how the Geoffrey Beene Center helped Memorial Sloan-Kettering establish a progressive approach to modern cancer research.

Pictured: Scott Lowe & Zhen Zhao
Pictured: Luciano Martelotto, Catherine Cowell & Jorge Reis-Filho
At Work: Experimental Pathologist Jorge Reis-Filho

Jorge Reis-Filho studies the genetic alterations that drive the malignant behavior of cells in rare types of breast cancer.

Pictured: Luciano Martelotto, Catherine Cowell & Jorge Reis-Filho
Pictured: Scott Armstrong, Michael Kuehn, Haijhua Chu, Monica Cusan & Andrei Kritsov
At Work: Pediatric Oncologist Scott Armstrong

Scott Armstrong specializes in the treatment of leukemia in children. His research focuses on the disease in children and adults.

Pictured: Scott Armstrong, Michael Kuehn, Haijhua Chu, Monica Cusan & Andrei Kritsov
Pictured: Charles Sawyers
Research Suggests a New Approach for Overcoming Resistance to a Targeted Therapy for Prostate Cancer

Research suggests that a new drug could be effective in patients with prostate cancer who develop resistance to the targeted therapy enzalutamide.

Pictured: Charles Sawyers