Human Oncology & Pathogenesis Program

Our teams of physician-scientists are working to translate molecular insights into new treatments for cancer.

Physician-scientist David Solit focuses on the development of cancer therapies that target pathways responsible for cancer initiation and progression.

Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.

Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic transcription factors in GIST and other solid tumors.

Physician-scientist Sarat Chandarlapaty studies the regulation of growth factor signaling networks in cancer.

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HOPP Year in Review

One of the goals of the Human Oncology and Pathogenesis Program (HOPP) is to achieve progress in various areas of cancer research. In our 2011 Year in Review, learn about our collaborations, innovations, and training that have had an impact on Memorial Sloan Kettering and its patients.

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Pictured: José Baselga
Memorial Sloan Kettering Featured Prominently at Major Cancer Research Meeting

Discoveries made at Memorial Sloan Kettering receive recognition at the 2014 Annual Meeting of the American Association for Cancer Research.

Pictured: José Baselga
Pictured: Charles L. Sawyers, William Polkinghorn & Simon Powell
Molecular Studies Explain Effectiveness of Longtime Treatment for Prostate Cancer

Laboratory studies have revealed an explanation for why androgen-deprivation therapy makes radiation therapy more effective in the treatment of high-risk prostate cancer.

Pictured: Charles L. Sawyers, William Polkinghorn & Simon Powell
Pictured: José Baselga
Physician-in-Chief José Baselga Elected President of the American Association for Cancer Research

As leader of the world’s oldest and largest professional organization dedicated to advancing cancer research, Dr. Baselga will expand his role in accelerating cancer prevention and discovery.

Pictured: José Baselga
Study Reveals Genetic Causes for Thyroid Cancer Increase after Chernobyl

The study of some victims exposed to ionizing radiation from the 1986 Chernobyl nuclear power plant accident is yielding new information about how radiation-induced thyroid cancer develops.

Pictured: Sarat Chandarlapaty
Researchers Identify Mutations that Cause Some Breast Cancers to Resist Treatment

Memorial Sloan Kettering researchers have found genetic mutations that cause some breast cancers to develop resistance to hormone therapy.

Pictured: Sarat Chandarlapaty