Research in the Bachovchin lab focuses on characterizing the functions of enzymes in normal and pathological processes. In particular, we are interested in the roles that serine proteases play in cancer and immune system signaling. We use a variety of tools and approaches to study these enzymes and pathways, including new chemical probes developed in our lab, mass spectrometry-based proteomics, activity-based protein profiling, and genome engineering (CRISPR).
- Okondo, M.; Johnson, D. C., Sridharan, R., Go, E. B., Chui, A. J., Wang, M. S., Poplawski, S. E., Wu, W., Liu, Y.; Lai, J. H.; Sanford, D. G.; Arciprete, M. O.; Golub, T. R.; Bachovchin, W. W.; Bachovchin, D. A. “Inhibition of DPP8/9 induces pro-caspase-1-dependent pyroptosis in monocytes and macrophages.” Nat Chem Biol. 2016, in press.
- Bachovchin, D. A.; Mohr, J. T.; Speers, A. E.; Wang, C.; Berlin, J. M.; Spicer, T. P.; Fernandez-Vega, V.; Chase, P.; Hodder, P. S.; Schürer, S. C.; Nomura, D. K.; Rosen, H.; Fu, G. C.; Cravatt, B. F. “Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.” Proc Natl Acad Sci. 2011, 108, 6811-6816.
- Josie Robertson Investigator (2015-2020)
- California Breast Cancer Research Program Fellowship (2011-2012)
- National Science Foundation Predoctoral Fellowship (2006-2007)