Molecular Biology Program
The Kenneth Marians Lab
Research
Kenneth J. Marians, PhD
William E. Snee Chair
Research in my laboratory centers on: (i) the events that occur when the replisome (the multi-component enzyme machine that replicates chromosomal DNA) encounters blockages to replication fork progression, and (ii) the mechanisms by which chromosomes are condensed and separated during cell division. Our studies on the consequences of replication fork blockage and restart utilize purified replication, recombination, and transcription proteins in various well-defined systems reconstituted in vitro that model all steps of these events. Our studies on chromosome condensation and segregation utilize a combination of biochemical, cell biological, and molecular genetic approaches.
Research Projects
Featured News
Feature
Remembering Jerard Hurwitz, a Giant of Molecular Biology
MSK colleagues pay tribute to molecular biologist Jerard Hurwitz’s scientific accomplishments and passion for discovery.
Q&A
Reflecting on 15 Years of Leadership: An Interview with Outgoing GSK Dean Ken Marians
Meet the man who helped make the Gerstner Sloan Kettering Graduate School of Biomedical Sciences a reality.
In the News
MSK’s Graduate School Welcomes New Dean, Bids Farewell to Its First
Cell biologist Michael Overholtzer will succeed DNA replication expert Ken Marians.
People
Kenneth J. Marians, PhD
William E. Snee Chair
- Kenneth Marians focuses on mechanisms of replication restart and chromosome segregation.
- PhD, Cornell University
- [email protected]
- Email Address
- 212-639-5890
- Office Phone
Members
Research Scholar
Senior Research Assistant
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Postdoctoral Fellow
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