The major goal of our research is to understand how the number of an important cellular organelle — the centrosome — is maintained during cell division and development. The centrosome is the main organizer of the microtubule cytoskeleton, exerting spatial and temporal regulation over the formation of microtubule polymers. The centrosome has profound effects on mitotic spindle formation; therefore, regulation of centrosome duplication is fundamental to genome stability.
- Kim M, O’Rourke BP, Soni RK, Jallepalli PV, Hendrickson RC, Tsou MF. (2016). Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis. Cell Rep. pii: S2211-1247(16)30838-5.
- Fong CS, Mazo G, Das T, Goodman J, Kim M, O’Rourke BP, Izquierdo D, Tsou MF. (2016). 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. Elife. 5. pii: e16270.