Developmental Biology Program
The Alexandra Joyner Lab
The Joyner lab studies how genes regulate the cell behaviors (proliferation, differentiation, migration) that underlie organ development, tissue repair and cancer. They focus on the brain where stem cells must produce hundreds of cell types at the right times and in the correct numbers, and the cells then migrate to the correct positions and synapse with partners. The lab uses sophisticated mouse genetics approaches to probe how cell-cell communication and cell intrinsic genetic programs determine the way by which normal cerebellar circuitry is established and regulates behaviors, or are disrupted in diseases including cancer.
Bayin N. Sumru, Mizrak Dogukan, Stephen Daniel N., Lao Zhimin, Sims Peter A., Joyner Alexandra L.. Injury-induced ASCL1 expression orchestrates a transitory cell state required for repair of the neonatal cerebellum. Science Advances. 2021 December; 7(50):eabj1598. doi: 10.1126/sciadv.abj1598.
Tan IL, Arifa RDN, Rallapalli H, Kana V, Lao Z, Sanghrajka RM, Sumru Bayin N, Tanne A, Wojcinski A, Korshunov A, Bhardwaj N, Merad M, Turnbull DH, Lafaille JJ, Joyner AL. CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model. Oncogene. 2020 Jan;40(2):396-407. doi: 10.1038/s41388-020-01536-0. Epub 2020 Nov 6. PubMed PMID: 33159168; PubMed Central PMCID: PMC7855734.
Ahmadzadeh, E., A., Bayin, N.S., Qu, X., Singh, Madisen, L., Stephen, D., Zeng, H., Joyner, A.L.* and Rosello-Diez, A.* (2020) A collection of genetic mouse lines and related tools for inducible and reversible intersectional misexpression. Development, 147 dev186650
Lawton, A., Engstrom, T., Rohrbach, D., Mamou, J., Turnbull, D.H., Zhang, T., Schwarz, J. and Joyner, A.L. (2019) Brain folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern. eLife, 8. pil: e45019.
Willett, R.T*., Bayin, N.S.*, Lee, A.S.*, Krishnamurthy, A.*, Wojcinski, A.*, N., N.S., Lao, Z., Stephen, D., Rosello-Diez, A., Dauber, K.L., Orvis, G.D., Wu, Z., Tessier-Lavigne, M. and Joyner, A.L. (2019) Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cells and organ growth. eLife, Nov 19;8. pii: e50617
Alexandra Joyner, PhD
- The Joyner laboratory studies the involvement of Hedgehog signaling and transcription factors in cerebellum development, regeneration and cancer.
- PhD, University of Toronto
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Alexandra Joyner discloses the following relationships and financial interests:
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