Molecular Biology Program

The Dirk Remus Lab

Research

Dirk Remus
Dirk Remus, PhD

We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated chromatin states. As chromosomes are the carriers of both the genetic and epigenetic information, faithful chromosome replication is of fundamental importance for genome maintenance during normal cell proliferation. Accordingly, defects in chromosome replication are a major driver of the genomic instability observed in cancer cells. To understand the molecular mechanisms by which eukaryotic cells carry out and monitor accurate genome replication we employ a fully reconstituted DNA replication system based on purified proteins from the budding yeast, S. cerevisiae. Research projects are focused on the mechanistic characterization of the DNA replication machinery, the mechanism of replication-coupled chromatin assembly, and the control of DNA replication by checkpoint genome surveillance pathways.

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The Dirk Remus Lab

Publications

Abd Wahab S and Remus D. Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53. eLife 2020; Jul 23;9:e58571. doi: 10.7554/eLife.58571.

Devbhandari S and Remus D. Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks. Nature Structural and Molecular Biology 2020; 27(5):461-471.

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People

Dirk Remus

Dirk Remus, PhD

  • Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.
  • PhD, University of California, Berkeley
remusd@mskcc.org
Email Address
212-639-5263
Office Phone

Members

Lisbelle Adorno

Administrative Assistant

Sujan Devbhandari
Sujan Devbhandari

Postdoctoral Fellow

Charanya Kumar
Charanya Kumar

Postdoctoral Associate

Dirk Remus
Dirk Remus

Associate Member

Ademola Adegbemigun
Ademola Adegbemigun

Research Technician

Juan Castaneda
Juan Castaneda

Graduate Student

Syafiq Abd Wahab
Syafiq Abd Wahab

Graduate Student

Lab Alumni
Julien Gros

Research Fellow

Gerard P. Lynch
Gerard P. Lynch

Research Fellow

Lab Affilations

Achievements

  • Louis V. Gerstner, Jr. Young Investigator Award, Memorial Sloan Kettering Cancer Center (2011)
  • Long-Term Fellow, EMBO (2006)

Open Positions

Career Opportunities

Postdoctoral positions are available.

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Dirk Remus discloses the following relationships and financial interests:

No disclosures meeting criteria for time period


The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

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