Molecular Biology Program
The Dirk Remus Lab
We are interested in the mechanism of chromosome replication, a process that is highly conserved across eukaryotes and that involves the duplication of both the chromosomal DNA and its associated chromatin states. As chromosomes are the carriers of both the genetic and epigenetic information, faithful chromosome replication is of fundamental importance for genome maintenance during normal cell proliferation. Accordingly, defects in chromosome replication are a major driver of the genomic instability observed in cancer cells. To understand the molecular mechanisms by which eukaryotic cells carry out and monitor accurate genome replication we employ a fully reconstituted DNA replication system based on purified proteins from the budding yeast, S. cerevisiae. Research projects are focused on the mechanistic characterization of the DNA replication machinery, the mechanism of replication-coupled chromatin assembly, and the control of DNA replication by checkpoint genome surveillance pathways.
Multistep loading of a DNA sliding clamp onto DNA by replication factor C. Schrecker M, Castaneda JC, Devbhandari S, Kumar C, Remus D, Hite RK. Elife. 2022 Aug 8;11:e78253. doi: 10.7554/eLife.78253.
CMG helicase activity on G4-containing DNA templates. Batra S, Devbhandari S, Remus D. Methods Enzymol. 2022;672:233-260. doi: 10.1016/bs.mie.2022.02.020. Epub 2022 Mar 25.
Yeast ORC sumoylation status fine-tunes origin licensing. Regan-Mochrie G, Hoggard T, Bhagwat N, Lynch G, Hunter N, Remus D, Fox CA, Zhao X. Genes Dev. 2022 Aug 4. doi: 10.1101/gad.349610.122. Online ahead of print.
A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Chen T, Alcorn H, Devbhandari S, Remus D, Lacy E, Huangfu D, Anderson KV. Biol Open. 2022 Aug 15;11(8):bio059307. doi: 10.1242/bio.059307. Epub 2022 Aug 8.
Dirk Remus, PhD
- Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.
- PhD, University of California, Berkeley
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- Louis V. Gerstner, Jr. Young Investigator Award, Memorial Sloan Kettering Cancer Center (2011)
- Long-Term Fellow, EMBO (2006)
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