Developmental Biology Program

The Junhong Choi Lab

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Research

Junhong Choi
Junhong Choi, PhD
Assistant Member

The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development. During development, cells differentiate into various cell types with distinct functions. To understand how different cell types are made, we need a tool to observe cells’ previous and current states, as well as the sequence of events they undergo. We focus on developing such new tools through:

  1. Cellular engineering
  2. Molecular circuitry
  3. DNA as an information storage medium, and
  4. Synthetic models for cellular development

These novel tools will provide new insights into understanding cell-fate decisions and facilitate cellular engineering for future therapy.
 

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Research Projects

Publications Highlights

Junhong Choi#, Wei Chen, Anna Minkina, Florence M. Chardon, Chase C. Suiter, Samuel G. Regalado, Silvia Domcke, Nobuhiko Hamazaki, Choli Lee, Beth Martin, Riza M. Daza, Jay Shendure#. “A time-resolved, multi-symbol molecular recorder via sequential genome editing” Nature 608, 98-107 (2022)

Wei Chen*,#, Junhong Choi*, Jenny F. Nathans, Vikram Agarwal, Beth Martin, Eva Nichols, Anh Leith, Choli Lee, Jay Shendure#. “Multiplex genomic recording of enhancer and signal transduction activity in mammalian cells” bioRxiv (preprint) (2021)

Junhong Choi#, Wei Chen, Hanna Liao, Xiaoyi Li, Jay Shendure#. “A molecular proximity sensor based on an engineered, dual-component guide RNA” bioRxiv (preprint) (2023)

Junhong Choi*,#, Wei Chen*, Chase C. Suiter, Choli Lee, Florence M. Chardon, Wei Yang, Anh Leith, Riza M. Daza, Beth Martin, Jay Shendure#. “Precise genome deletions using paired prime editing” Nature Biotechnology 40, 218-226 (2021)

Xiaoyi Li, Wei Chen, Beth K. Martin, Diego Calderon, Choli Lee, Junhong Choi, Florence M. Chardon, Troy McDiarmid, Haedong Kim, Jean-Benoit Lalanne, Jenny F. Nathans, Jay Shendure. “Chromatin context-dependent regulation and epigenetic manipulation of prime editing” bioRxiv (preprint) (2023)

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People

Junhong Choi

Junhong Choi, PhD

Assistant Member

  • The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.
[email protected]
Email Address

Members

Stephanie Martinez

Administrative Assistant

Lab Affiliations

Achievements

  • Damon Runyon-Dale F. Frey Award for Breakthrough Scientists (2024-2026)
  • K99/R00 Pathway to Independence Award (2023-2027)
  • Damon Runyon Cancer Research Fellowship (2020-2023)
  • Stanford Bio-X Graduate Fellowship (2015-2018)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

General Opportunities

We are actively recruiting research scientists, postdoctoral fellows, and graduate students who are interested in synthetic biology, stem-cell biology, single-cell genomics, and developmental biology.

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