Cell Biology Program
The Lydia Finley Lab
Research

The Finley Lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. We combine genetic and metabolomic approaches to investigate cell-type specific growth requirements and elucidate how flux through central metabolic pathways regulates key cellular activities, including self-renewal and differentiation. In particular, we are interested in understanding how changes in metabolite availability shape the chromatin landscape to influence gene expression programs that control cell survival, growth and differentiation. Our work aims to answer fundamental questions about how cells regulate the commitment to differentiation and how failure to execute terminal differentiation can underlie diseases such as cancer.
Inside My Lab: Lydia Finley

Featured News



Publications
A non-canonical tricarboxylic acid cycle underlies cellular identity. Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. Nature. 2022 Mar;603(7901):477-481. doi: 10.1038/s41586-022-04475-w. Epub 2022 Mar 9. PMID: 35264789; PMCID: PMC8934290.
Extracellular serine controls epidermal stem cell fate and tumour initiation. Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E#, Finley LWS#. Nat Cell Biol. 2020 Jul;22(7):779-790. doi: 10.1038/s41556-020-0525-9. Epub 2020 May 25. Erratum in: Nat Cell Biol. 2020 Nov;22(11):1396. PMID: 32451440; PMCID: PMC7343604. (#co-corresponding author)
People

Lydia Finley, PhD
Geoffrey Beene Junior Faculty Chair
- Lydia Finley studies the mechanisms that link metabolic pathways to cell fate decisions.
- PhD, Harvard University
- BS, Yale University
- [email protected]
- Email Address
- 212-639-6722
- Office Phone
Members


- Phd in Immunology, Medical University of Vienna






Research Associate

Research Fellow

Graduate Student

Graduate Student

Graduate Student

Graduate Student

MSK Bridge Program Scholar

Research Fellow

Sr. Administrative Assistant

- BS, Duke University


- B.S.
Lab Alumni

Postdoctoral Associate at Rockefeller University, New York, NY

Research Technician

Graduate Student

Medical Resident

Graduate Research Assistant
Lab Affiliations
Achievements
- New York Stem Cell Foundation – Robertson Investigator (2023)
- Louise and Allston Boyer Young Investigator Award for Basic Research (2022)
- National Cancer Institute R37 MERIT Award (2020)
- Pershing Square Sohn Prize for Cancer Research (2020)
- Searle Scholar (2018)
Read more
- Dale F. Frey Breakthrough Award of the Damon Runyon Cancer Research Foundation (2017)
Lab News & Events
Accolades
Team Recognitions
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Paige Arnold, Gerstner Sloan Kettering Chairman’s Prize (2022)
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Paige Arnold, Weintraub Award (2022)
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Sanjeethan Baksh, STAT Wunderkind (2022)
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Benjamin Jackson, NIH/NICHD F31 (2022)
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Katrina Paras, Bruce Charles Forbes Pre-Doctoral Fellowship (2021)
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Benjamin Jackson, Gerstner Sloan Kettering Grayer Fellowship (2021)
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Julia Brunner, Human Frontier Science Program Fellowship (2021)
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Sanjeethan Baksh, Olaf S. Anderson Physician-Scientist Award (2021)
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Paige Arnold, NIH/NICHD F31 (2019)
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Jossie Yashinskie, AACR Minority Scholar in Cancer Research Award (2018)
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Jossie Yashinskie, NIH/NICHD T32 fellowship (2018)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
Get in Touch
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