The Max Wilkinson Lab
Research
Genetic information typically flows in one direction: from DNA to RNA to protein. Our lab is fascinated by reverse transcription, where this flow is flipped on its head, allowing RNA to be rewritten back into DNA. Reverse transcriptases are famously used by retroviruses like HIV to invade genomes, but it turns out they are used by more than just genomic parasites.
In the Wilkinson lab, we explore the frontiers of RNA biology by discovering new functions for reverse transcription. We already recognise that fundamental phenomena in molecular biology like splicing and telomere extension evolved from this ancient process, and we want to know: What else is out there? Using a combination of biochemistry, microbiology, and structural biology, we aim to discover new biological functions and harness them for applications in genomic medicine.
More information about our research can be found at wilkinsonlab.bio.
Research Projects
Publications Highlights
Wilkinson ME, Li D, Gao A, Macrae RK, Zhang F
Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA.
Science. 2024 Apr 5;384(6690):61-67. doi: 10.1126/science.adj3563
PMID: 39208082
Wilkinson ME, Frangieh CJ, Macrae RK, Zhang F
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription.
Science. 2023 Apr 7;380(6640):eabn8990. doi: 10.1126/science.abn8990
PMID: 37023171
Faure G*, Saito M*, Wilkinson ME*, Quinones-Olvera N, Xu P, Flam-Shepherd D, Kim S, Reddy N, Zhu S, Evgeniou L, Koonin EV, Macrae RK, Zhang F
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses.
Science. 2025 Jul 5;381(6651):50-57. doi: 10.1126/science.ado2503
PMID: 40014690
Wilkinson ME*, Charenton C*, Nagai K*
RNA Splicing by the Spliceosome.
Annu Rev Biochem. 2020 Jun 20;89:359-388. doi: 10.1146/annurev-biochem-011520-104722
PMID: 31794245
Wilkinson ME, Fica SM, Galej WP, Norman CM, Newman AJ, Nagai K
Postcatalytic spliceosome structure reveals mechanism of 3’-splice site selection.
Science. 2017 Nov 17;358(6368):1283-1288. doi: 10.1126/science.aao6535
PMID: 29146871
People
Max Wilkinson, PhD
- The Wilkinson laboratory studies reverse transcriptases and retrotransposons using biochemistry, structural biology, and genome mining.
- BSc (Hons) Biochemistry, University of Otago (2015)
- PhD, MRC Laboratory of Molecular Biology, University of Cambridge (2019)
- Postdoc, Broad Institute / Massachusetts Institute of Technology (2025)
- [email protected]
- Email Address
Achievements
- Helen Hay Whitney Postdoctoral Fellowship (2022-2024)
- RNA Society/Scaringe Young Scientist Award (2019)
- Max Perutz Student Prize (MRC LMB) (2018)
- Cambridge-Rutherford Memorial Scholarship (Royal Society of New Zealand) (2015 – 2017)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Postdocs / PhD students / Technicians
Get in Touch
-
Lab Head Email
Disclosures
Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.
MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.
Max Wilkinson discloses the following relationships and financial interests:
-
Broad Institute of MIT and Harvard
Intellectual Property Rights
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2025 through disclosure submission in spring 2026). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].