Computational & Systems Biology Program

The Thomas Norman Lab


Thomas Norman
Thomas Norman, PhD

The Norman Lab aims to combine large-scale functional genomics experiments with computational modeling to enable rational engineering of cell state. Our primary model system is the fibroblast, a ubiquitous and phenotypically plastic cell type that plays a role in diverse pathologies. We played a foundational role in developing the Perturb-seq approach for single-cell CRISPR screening and continue to develop new approaches to enable functional genomics experiments beyond genome-scale. Our ultimate goal is to learn principles for precisely controlling cellular behavior, with potential applications in cell therapy and disease modeling.

View Lab Overview


Tom Norman Lab

Publications Highlights

Replogle, J.M.*, Saunders, R.A.*, Pogson, A.N., Hussmann, J.A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E.J., Adelman, K., Bonnar, J.L., Jost, M., Norman, T.M.† and Jonathan S Weissman.† Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq. Cell vol. 185 2559-2575.e28 (2022).

Norman, T.M.*, Horlbeck, M.*, Replogle, J., Ge, A., Xu, A., Jost, M., Gilbert, L., & Weissman, J.S. Exploring genetic interaction manifolds constructed from rich phenotypes. Science 365, 786-793 (2019).

Adamson, B.*, Norman, T.M.*, Jost, M., Cho, M.Y., Nuñez, J.K., Chen, Y., Villalta, J.E., Gilbert, L.A., Horlbeck, M.A., Hein, M.Y. Pak, R.A., Gray, A.N., Gross, C.A., Dixit, A. Parnas, O., Regev, A. & Weissman, J.S. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response.  Cell 167, 1867-1882 (2016).

View All Publications


Thomas Norman

Thomas Norman, PhD

  • Systems biologist Thomas Norman develops new computational and functional genomics approaches for studying how genes interact to realize complex phenotypes.
  • PhD, Harvard University
[email protected]
Email Address


Rico Ardy
Rico Ardy

Research Fellow

Daniel Cizin

Graduate Student

Ashleigh Donnellan

Administrative Assistant, Sr.

Deirdre O'Sullivan

Graduate Student

Olatunji Oni
Olatunji Oni

Graduate Student

Kaden Southard
Kaden Southard

Research Scholar

Anran Tang

Graduate Student

Lab Alumni
Emily Budhram

Research Technician

Rafaela Mendes

Laboratory Technician

Lab Affiliations


  • Josie Robertson Investigator (2019-2024)
  • Damon Runyon-Dale F. Frey Award for Breakthrough Scientists (2019)
  • Damon Runyon Cancer Research Foundation Fellowship (2015-2018)
  • NIH Director's New Innovator Award (2020)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Get in Touch

Lab Resources

Please contact:

Ashleigh Donnellan

Administrative Assistant

[email protected]


Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Thomas Norman discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

View all disclosures