Chemical Biology Program

The Yael David Lab


Yael David
Yael David, PhD

Research efforts in the David lab apply core techniques in chemical biology, biochemistry, and cell biology to address fundamental questions in the epigenetic regulation of transcription. Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and utilize chemical methods to synthesize site-specifically modified histones in vitro and in vivo and study the roles that these modifications play in disease states, with the ultimate goal of targeting them for therapeutics.

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Publications Highlights

Zheng Q, Omans ND, Leicher R, Osunsade A, Agustinus AS, Finkin-Groner E, D’Ambrosio H, Liu B, Chandarlapaty S, Liu S, David Y. Reversible histone glycation is associated with disease-related changes in chromatin architecture. Nat Commun. 2019 Mar 20;10(1):1289. doi: 10.1038/s41467-019-09192-z

Osunsade A, Prescott NA, Hebert JM, Ray DM and David Y. A Robust Method for the Purification and Characterization of the Human Histone H1 Variants. Biochemistry. 2018 Dec 26. doi: 10.1021/acs.biochem.8b01060.

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Yael David

Yael David, PhD

  • Yael David’s lab develops and applies methods in chemical biology toward studying epigenetic regulation and its correlation with disease states.
  • Ph.D – The Weizmann Institute of Science
  • B.Sc SUNY Stony Brook
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Yael David
Yael David

Assistant Member

Ifeh Akano
Ifeh Akano

WCM Pharmacology Graduate Student

Brittney Bobowski

WCM Pharmacology Graduate Student

Sarah Faulkner

Research Fellow

Rasmus Pihl
Rasmus Pihl

Research Fellow

Nicholas Prescott, Graduate Student
Nicholas Prescott

TPCB Graduate Student

Devin Ray
Devin Ray

TPCB Graduate Student

Nicole Walker

TPCB Graduate student

Yang Xiao

TPCB Graduate student

Lab Alumni
Hannah D'Ambrosio

Research Assistant

Albert Agustinus, Research Technician
Albert Agustinus

Research Technician

Efrat Finkin, Research Associate
Efrat Finkin

Research Associate

Jakob Hebert, TPCB Graduate Student
Jakob Hebert

TPCB Graduate Student

Igor  Maksimovic
Igor Maksimovic

TPCB Graduate Student

Nathaniel Omans, Graduate Student
Nathaniel Omans

Rotation Student

Adewola Osunsade, TPCB Graduate Student
Adewola Osunsade

TPCB Graduate Student

Akhil Upad

Research Technician

Qingfei Zheng, Research Fellow
Qingfei Zheng

Research Fellow

Lab Affiliations


  • Josie Robertson Investigator (2016-2021)
  • Pershing Square Sohn Cancer Alliance Award
  • Experimental Therapeutic Discovery Center grant
  • Specialized Program of Research Excellence (SPORE) Award
  • CEBRA award
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  • Parker Institute for Cancer Immunotherapy Award
  • Star Cancer Consortium grant
  • The Center for Educational Resources Project Collaborative Grant
  • National Institute of General Medical Sciences grant

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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Yael David discloses the following relationships and financial interests:

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