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Proof of Principle: Tri-Institutional Therapeutics Discovery Institute Drug Candidates “Graduate” to Next Phase of Development

Two projects from a portfolio of 57 that the Tri-I TDI has supported have “graduated” with the demonstration that the compounds under study work in preclinical contexts. These compounds are now ready for the next phase of therapeutic development – a phase intended to lead to investigational new drugs. A third project, which originated at Weill Cornell Medicine, is expected to move forward later this month. These projects are candidates for advancement into Bridge Medicines, Inc., a for-profit company established in 2016 by the three Tri-I TDI academic founders, Takeda, and two investment firms – Bay City Capital and Deerfield Management – designed to take Tri-I TDI projects into readiness for clinical trials over a two- to three-year time frame.
A gray blob marked RAS linked to colorful rods marked ICMT
In the Lab
Deciphering How Membrane Enzymes Work, with a Little Help from Beetles

The atomic structure of an elusive type of membrane protein has finally been solved by scientists at the Sloan Kettering Institute.
Illustration of cells with blue nuclei that have green DNA bits floating in the cytoplasm
In the Lab
Escape Artists: Cancer Cells Mimic Immune Cell Activity to Spread

Researchers have discovered that cancer cells may hijack an immune response to spread from a primary tumor to distant organs.
Three-dimensional reconstruction of the blood vessels in a mouse thymus using light-sheet fluorescent microscopy
In the Lab
New Hope for Repairing a Damaged or Aging Immune System

Scientists have uncovered a molecule that, in mice, can promote the regeneration of the thymus, where T cells develop.
MP1104 binding to the kappa opioid receptor
Q&A
Building a Safer Opioid: MSK Research Seeks to Develop New Ways to Relieve Pain

Science could lead to a new type of opioid drug that blocks pain but has a lower potential for addiction or abuse.
A barred Plymouth Rock hen
Feature
How a Chicken Helped Solve the Mystery of Cancer

When this feathered patient found her way into a New York laboratory in 1909, she changed the course of cancer science.
Gears with 2016 and 2017
In the News
Year in Review: The Science and Technology that Shaped Cancer Care in 2017

As 2017 draws to a close, take a look back at the scientific discoveries that deepened our understanding of cancer in the past year.
Sloan Kettering Institute Director Joan Massagué with laboratory member Karuna Ganesh
In the Lab
When Cancer Spreads: Research Focuses on Better Ways to Treat Metastasis

MSK investigators are learning how cancer cells escape from the original tumor and hide out in the body. Their goal is to prevent metastatic tumors from forming.
A microscopic view of genetically engineered mouse tumor and a human FL-HCC tumor
In the Lab
With Help of CRISPR, Scientists Unravel the Cause of a Rare Liver Cancer

A team led by MSK molecular biologist Scott Lowe is making progress against fibrolamellar hepatocellular carcinoma.
Prostate cancer cells, colored red in scanning electron micrograph (SEM).
Science Byte
PSMA: A New Target for Prostate Cancer Treatment

Researchers have discovered how a high level of the protein PSMA in cells helps fuel prostate cancer.