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Scientists at the Sloan Kettering Institute are learning why some immune cells are stubbornly hard to revive with immunotherapy.
In the Lab
Why Immune Cells Sometimes Fail to Fight Cancer (and What to Do about It)

By looking at how DNA is packaged in cells, scientists are teasing apart a long-standing conundrum about the immune response to cancer.
MSK Symposium Honors Dinshaw Patel, Titan of Structural Biology
Announcement
MSK Symposium Honors Dinshaw Patel, Titan of Structural Biology

Scientists came to MSK to celebrate the 75th birthday of a leader in the field of structural biology.
Cancer biologist and pediatric oncologist Alex Kentsis
In the Lab
Jumping Genes and the Dark Genome: MSK Researchers Gain New Insight into Childhood Cancers

Researchers have discovered a genetic mechanism that may trigger most childhood cancers.
Mount Rushmore viewed through face-detection software.
Making a Splash: Researchers Apply Face-Detection Technology to the Study of Genes

Taking a cue from smartphone technology, scientists are using face-recognition algorithms to improve RNA interference.
Grey T lymphocytes
Finding
#AACR17: Researchers Shed Light on Biological Activity of a New, First-in-Class Immunotherapy

A team at MSK uncovered how TRX518, a new immunotherapy drug in early development, works in the body.
Wearable device on woman’s arm with labels indicating beams going into nanotubes and coming back out for analysis.
In the Lab
Detective Work: How Implantable Nanosensors Could Monitor Cancer Activity

Learn how tiny sensors made of nanotubes could serve as implantable devices that offer a noninvasive way to monitor cancer and its treatments.
Adrienne Boire at the lab bench
In the Lab
Inspired by a Patient, a Doctor Finds Answers for a Devastating Cancer Complication

Research is providing new clues about how cancer spreads to spinal fluid, a condition called leptomeningeal metastasis.
Molecular biologist John Petrini of the Sloan Kettering Institute.
Feature
Understanding the DNA-Damage “First Responders”: John Petrini at Work

Scientists know that cancer can result from mistakes in DNA repair. But understanding what controls the repair process itself has been a hard nut to crack.
CAR T Cells More Powerful When Built With CRISPR, MSK Researchers Find

MSK researchers used the genome-editing tool CRISPR to create more potent chimeric antigen receptor (CAR) T cells that don't tire as easily when attacking cancer cells. The unexpected findings were published in the journal Nature on February 22 and underscore the potential of genome editing to advance immunotherapy for cancer.
CAR T cells attacking cancer
In the Lab
CRISPR Genome-Editing Tool Takes Cancer Immunotherapy to the Next Level

What do you get when you combine two of the hottest areas of biotechnology? A new paper from MSK researchers explains.