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Dana Pe'er, Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute
Year in Review: Top 10 MSK Cancer Science Breakthroughs of 2020

Take a look back at some of the biggest cancer science stories from this past year.
Structure of an intermediate during the homologous recombination reaction.
Wielding Powerful Imaging Tools, MSK Researchers Decipher Process of DNA Repair

The high-resolution views provided by cryo-electron microscopy are helping scientists learn how proteins and DNA collaborate to repair broken DNA.
Nadeem Riaz (left) and Jorge Reis-Filho (right)
For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment

Human data and results from mouse experiments suggest that people with BRCA2 mutations may respond well to immunotherapy drugs.
Systems biologist Joao Xavier in his lab
Finding
MSK Study Is the First to Link Microbiota to Dynamics of the Human Immune System

MSK researchers have shown for the first time that the concentration of different types of immune cells in the blood changes in relation to the presence of different bacterial strains in the gut.
SKI cell biologists Junmei Yi and Xuejun Jiang
In the Lab
More Evidence that Cellular ‘Death by Iron’ Could Be Promising Avenue of Cancer Treatment

Cancers with certain mutations are vulnerable to ferroptosis, a form of iron-dependent cell death.
An illustration of a reel of film
In the Lab
Feature Presentation: 3D Movies of Cell Signaling in Early Development from the Hadjantonakis Lab

Grab your popcorn and pull up a chair for these video shorts of cell signaling in early mouse development.
MSK immunologist Ming Li.
In the Lab
MSK-led Studies Support the Concept of “Cancer Environment Immunotherapy”

Targeting the cancer environment, rather than the cancer itself, could be a new avenue for immunotherapy.
MSK developmental biologist Lorenz Studer
Q&A
Taking Aim at Parkinson’s Disease: A Conversation with Developmental Biologist Lorenz Studer

In an interview in September 2020, Dr. Studer spoke about what he hopes he and his fellow investigators can accomplish with this generous support.
Regulatory proteins (gold balls) bind to enhancer regions (light blue) and promoter regions (pink) of DNA to form clusters that enable transcription (purple).
Going the Distance: How DNA Enhancers Communicate with Their Target Genes

Scientists at the Sloan Kettering Institute are learning how far-flung regions of genes connect to start the process of making proteins.
An illustration of a beta-amyloid plaque among the neurons in a brain.
Article
MSK Study Links Inflammation to Alzheimer’s Disease Development

An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.