Memorial Hospital Research Laboratories

The Kayvan Keshari Lab

Research

Pictured: Kayvan R. Keshari
Kayvan R. Keshari, PhD
Fred Lebow Chair at MSK

The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized magnetic resonance, allowing us the ability to bring these approaches to the clinic.

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The Kayvan Keshari Lab

Publications Highlights

DeBerardinis, R. J., & Keshari, K. R. (2022). Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell185(15), 2678–2689. https://doi.org/10.1016/j.cell.2022.06.029

Tee, S. S., Kim, N., Cullen, Q., Eskandari, R., Mamakhanyan, A., Srouji, R. M., Chirayil, R., Jeong, S., Shakiba, M., Kastenhuber, E. R., Chen, S., Sigel, C., Lowe, S. W., Jarnagin, W. R., Thompson, C. B., Schietinger, A., & Keshari, K. R. (2022). Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances8(14), eabm7985. https://doi.org/10.1126/sciadv.abm7985

Jeong, S., Savino, A. M., Chirayil, R., Barin, E., Cheng, Y., Park, S. M., Schurer, A., Mullarky, E., Cantley, L. C., Kharas, M. G., & Keshari, K. R. (2021). High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. Cell metabolism33(1), 145–159.e6. https://doi.org/10.1016/j.cmet.2020.12.005

Granlund, K. L., Tee, S. S., Vargas, H. A., Lyashchenko, S. K., Reznik, E., Fine, S., Laudone, V., Eastham, J. A., Touijer, K. A., Reuter, V. E., Gonen, M., Sosa, R. E., Nicholson, D., Guo, Y. W., Chen, A. P., Tropp, J., Robb, F., Hricak, H., & Keshari, K. R. (2020). Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell metabolism31(1), 105–114.e3. https://doi.org/10.1016/j.cmet.2019.08.024

Salamanca-Cardona, L., Shah, H., Poot, A. J., Correa, F. M., Di Gialleonardo, V., Lui, H., Miloushev, V. Z., Granlund, K. L., Tee, S. S., Cross, J. R., Thompson, C. B., & Keshari, K. R. (2017). In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell metabolism26(6), 830–841.e3. https://doi.org/10.1016/j.cmet.2017.10.001

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People

Pictured: Kayvan R. Keshari

Kayvan R. Keshari, PhD

Fred Lebow Chair at MSK

  • Biochemist and Bioengineer Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer therapeutics.
  • BA, University of California, Berkeley
  • PhD, University of North Carolina Chapel Hill
[email protected]
Email Address
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Physician profile

Members

Marjan Berishaj

Senior Research Technician

Ross Boltyanskiy, PhD
Ross Boltyanskiy

Assistant Director- Imaging & Bioengineering Lead

Yolanda Bryce, MD
Yolanda Bryce

Assistant Attending

Elizabeth Coffee
Elizabeth Coffee

Instructor, Neuro-Oncology

John Consiglio
Quinlan Cullen
Quinlan Cullen

Graduate Student

Lyric Haughton

Research Technician

Ana Mark

Project Coordinator

Celia Martinez de la Torre
Celia Martinez de la Torre

Research Scholar

Vesselin Miloushev
Vesselin Miloushev

Assistant Attending

Saket Patel
Saket Patel

Research Scholar

Thasin Peyear

Graduate Student

Paola Porcari
Paola Porcari

Senior Research Scientist

Thomas Ruan
Thomas Ruan

Graduate Student

Nancy Santiappillai
Nancy Santiappillai

Research Fellow

Tanya Schild
Tanya Schild

Research Fellow

Thomas Smoot
Thomas Smoot

Research Technician

Briana Turner

Graduate Student

Guannan Zhang
Guannan Zhang

Research Fellow

Lab Alumni
H. Nikki Aldeborgh
H. Nikki Aldeborgh

Research Technician

Julio Alvarez
Julio Alvarez

Research Technician

Giuseppe Carlucci

Research Scholar

Rachel Chirayil
Rachel Chirayil

Technician

Andrew Cho
Andrew Cho

Graduate Student

Kofi Deh
Kofi Deh

Research Fellow

Valentina Di Gialleonardo
Valentina Di Gialleonardo

Research Scholar

Lidia Dos Santos-Cunha
Lidia Dos Santos-Cunha

Research Fellow

Kristin Granlund
Kristin Granlund

Research Associate

Simran Gupta
Simran Gupta

Research Technician

Nathaniel Kim
Nathaniel Kim

Research Fellow

Hannah Lees
Hannah Lees

Research Fellow

Alex Poot, PhD
Alex Poot

Research Fellow

Lucia Salamanca-Cardona
Lucia Salamanca-Cardona

Research Fellow

Sui Seng Tee
Sui Seng Tee

Research Fellow

Steven Truong
Steven Truong

Graduate Research Assistant

Lab Affiliations

Achievements

  • NIH Pathway Independent Award 2012

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Kayvan R. Keshari discloses the following relationships and financial interests:

  • Atish Technologies, Inc.
    Equity; Intellectual Property Rights
  • Bruker BioSpin GmbH
    Professional Services and Activities (Uncompensated)
  • Imaginostics, Inc.
    Equity
  • NVision Imaging Technologies GmbH
    Equity; Professional Services and Activities

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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