Molecular Biology Program

The Iestyn Whitehouse Lab

Iestyn Whitehouse, PhD

Director of the Center for Epigenetics Research (CER)

The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches. We like to develop new technology and are particularly interested in the development and application of single molecule technologies such as Nanopore sequencing and single molecule indexing strategies.

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Research Projects

Featured News

At Work: Molecular Biologist Iestyn Whitehouse

Iestyn Whitehouse translated an early interest in woodworking into a career as a molecular biologist focused on the human genome's building blocks.

Recipients of the Louis V. Gerstner, Jr. Young Investigators Fund, pictured with Mr. Gerstner. (From left) Iestyn Whitehouse, Hans-Guido Wendel, Mr. Gerstner, Stephen Long, and Timothy Chan.

Memorial Sloan Kettering Names First Gerstner Fund Recipients

Memorial Sloan Kettering has announced the creation of the Louis V. Gerstner, Jr. Young Investigators Fund and has named the fund's first four recipients.

Publications Highlights

Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X.Genes Dev. 2023 Jan 26. doi: 10.1101/gad.350054.122.PMID: 36702483

Single-molecule mapping of replisome progression. Claussin C, Vazquez J, Whitehouse I.Mol Cell. 2022 Apr 7;82(7):1372-1382.e4. doi: 10.1016/j.molcel.2022.02.010. Epub 2022 Mar 2.PMID: 35240057

DNA replication through a chromatin environment. Bellush JM, Whitehouse I.Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731):20160287. doi: 10.1098/rstb.2016.0287.PMID: 28847824

DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNAreplication. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K.Elife. 2017 Mar 18;6:e22799. doi: 10.7554/eLife.22799.PMID: 28315523

Spatiotemporal coupling and decoupling of gene transcription with DNAreplication origins during embryogenesis in C. elegans. Pourkarimi E, Bellush JM, Whitehouse I.Elife. 2016 Dec 23;5:e21728. doi: 10.7554/eLife.21728.PMID: 28009254

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People

Iestyn Whitehouse, PhD

Director of the Center for Epigenetics Research (CER)

Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.
PhD, The University of Dundee

[email protected]: Email Address
212-639-8398: Office Phone

Members

Clémence Claussin
Sr. Research Scientist

Rebecca MacLean
SKI Administrative Assistant II

Lab Alumni

Lisbelle Adorno

Administrative Assistant

Jennifer Yavid — Jennifer A Yavid
Research Technician

Jieqing (Jenny) Jiang

Graduate Student

Graduate Student

Postdoctoral Fellow

Graduate Student

Postdoctoral Fellow

Graduate Student

Lab Affiliations

Get in Touch

[email protected]

Lab Head Email
212-639-8398

Office Phone

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Iestyn Whitehouse discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].

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