This laboratory is taking a biochemical approach to four problems in nucleic acid metabolism: the coordination of eukaryotic mRNA synthesis and processing, the structure and function of eukaryotic type I DNA topoisomerases, DNA damage recognition and repair by DNA ligases, and the mechanisms and biological roles of RNA repair enzymes.
Stewart Shuman, MD, PhD
Research FocusMolecular biologist Stewart Shuman studies mechanisms and structures of the mRNA cap-forming enzymes and the means by which capping is coupled to transcription.
EducationMD, PhD, Albert Einstein College of Medicine
- Changela A, Ho CK, Martins A, Shuman S, Mondragon A. (2001) Structure and mechanism of the RNA triphosphatase component of mammalian mRNA capping enzyme. EMBO J. 2001;20:2575-2586.
- Krogh BO, Shuman S. (2002) A poxvirus-like type IB topoisomerase family in bacteria. Proc Natl Acad Sci USA. 2002;99:1853-1858.