Molecular Cytology

Overview

Murray Tipping
Director

The Molecular Cytology Core Facility (MCCF) delivers specialized histology, microscopy, and cytogenetics services in support of research projects at MSK. The methodologies employed by the Core allow for detection in situ (cells, tissue sections, organoids, and whole mounts) of biomarkers (proteins, glycoproteins, lipids, nucleic acids) and molecular processes in normal and pathological conditions. Using machine-based protocols and advanced spatial biology instrumentation, many nucleic acid and protein markers (up to 50) can be visualized by multiplex staining in the same sample. In collaboration with end users, the Core performs comprehensive antibody validation on cells and tissues. The Core trains investigators in basic staining principles and assists with experimental assay design and downstream analysis. Using the Core’s widefield and confocal microscopes, users can image biological samples at all scales from subcellular compartments to live embryos. The Core maintains four whole-slide scanners and provides support for quantitative whole-slide analysis. Microscopy and dedicated image analysis staff provide strong post-acquisition support for simple or complex analysis pipelines. The Core’s optical tweezers instrument and two Atomic Force microscopes are heavily used to study molecular interactions at nanometer resolution, to evaluate the effect of inhibitors on pathologic processes, and to assess stiffness, tension, and rheology of cells and tissues from normal and cancer bearing animal models, as well as tissues from cancer patients. The Core provides in-house research cytogenetics services for preclinical mouse and human samples through in situ hybridization, karyotyping, whole chromosome painting, and optical genome mapping assays.

Intranet

Molecular Cytology’s Intranet site

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People

Members

Afsar Barlas
Afsar Barlas

Senior Research Scientist, Automated Histology

Ning Fan
Ning Fan

Research Assistant, Sr., Manual Histology

Yevgeniy Romin
Yevgeniy Romin

Digital Microscopy Specialist/Operations Coordinator, Microscopy

Jahkwaun Budhai

Research Technician, Histology

Eric Chan, MEng
Eric Chan

Research Assistant, Microscopy

Danica Clarke

Administrative Assistant

Trevor Fisher

Research Technician, Histology

Michael Galiano

Research Assistant, Microscopy

Crystal Huang

Research Technician, Histology

Wenfei Kang

Senior Research Scientist, Manual Histology

Young Hun Kim

Research Fellow, Microscopy

Prajakta Kokate

Senior Research Assistant, Histology

Francesca Mazzoni

Senior Reseatch Scientist, Histology

Shevin Narine

Research Assistant, Histology

 Eric Rosiek, MS
Eric Rosiek

Senior Research Technician, Microscopy

Anthony Santella

Senior Research Scientist, Microscopy

Bikhyat Shrestha

Research Assistant, Histology

Nada Wahman

Research Technician, Microscopy

Yicong Wang

Research Technician, Histology

Alumni
Sho Fujisawa
Sho Fujisawa

Research Assistant, Sr., Microscopy

Madeline Leung
Madeline Leung

Administrative Assistant

Xirong (Frank) Liu
Xirong (Frank) Liu

Lab Assistant

Mesruh Turkekul, BS
Mesruh Turkekul

Research Assistant, Manual Histology

Vitaly Boyko
Vitaly Boyko

Senior Research Scientist, Microscopy

Matthew Brendel

Junior Digital Microscopist

Evan Darling

Junior Digital Microscopist

Elvin Feng

Junior Digital Microscopist

Sharon Huang
Sharon Huang

Research Technician

Radoslaw Junka

Research Assistant, Manual Histology

Navid Paknejad
Navid Paknejad

Research Technician, Microscopy

Mamiko Swanson

Research Technician, Histology

Sadé Thomas

Administrative Assistant II

Dmitry Yarilin
Dmitry Yarilin

Senior Research Scientist, Automated Histology

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

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