The Alban Ordureau Lab

Alban Ordureau: Publications

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McKenna, M.J.*, Sim, S.I.*, Ordureau, A., Wei, L., Harper, J.W., Shao. S., Park E. (2020) The endoplasmic reticulum P5A-ATPase is a transmembrane helix dislocase. Science 369(6511)

Sinha, N.K.*, Ordureau, A.*, Best, K.M.*, Saba, J.A., Zinshteyn, B., Sundaramoorthy, E., Fulzele, A., Garshott, D.M., Denk, T., Thoms, M., Paulo, J.A., Harper, J.W., Bennett, E.J., Beckmann, R., Green, R. (2020) EDF1 coordinates cellular responses to ribosome collisions. eLife 9, e58828

An, H.*, Ordureau, A.*, Korner, M., Paulo, J.A., Harper, J.W. (2020) Systematic Quantitative Analysis of Ribosome Inventory During Nutrient Stress. Nature 583(7815), 303-309

Martinez-Chacin, R.C., Bodrug, T., Bolhuis, D.L., Kedziora, K.M., Bonacci, T., Ordureau, A., Gibbs, M.E., Weissmann, F., Qiao, R., Grant, G.D., Cook, J.G., Peters, J-M., Harper, J.W., Emanuele, M.J., Brown, N.G. (2020) Ubiquitin chain elongating E2 UBE2S activates the RING E3 APC/C for substrate priming with UBE2C. Nature Structural & Molecular Biology 27(6):550-560.

Ordureau, A., Paulo, J.A., Zhang, J., An, H., Swatek, K.N., Cannon, J.R., Wan, Q., Komander, D., Harper J.W. (2020) Global landscape and dynamics of Parkin and USP30-dependent ubiquitylomes in iNeurons during mitophagic signaling. Molecular Cell. 77(5):1124-1142.

Ahfeldt, T., Ordureau, A., Bell, C., Sarrafha, L., Sun, C., Piccinotti, S., Grass, T., Parfitt, G.M., Paulo, J.A., Yanagawa, F., Uozumi, T., Kiyota, Y., Harper, J.W., Rubin, L.L. (2020) Pathogenic pathways in early onset autosomal recessive Parkinson’s disease discovered using isogenic human dopaminergic neurons. Stem Cell Reports. 14 (1), 75-90.

Jacoupy, M., Hamon-Keromen, E., Ordureau, A., Erpapazoglou, Z., Coge, F., Corvol, J-C., Nosjean, O., Mannoury La Cour, C., Millan, M. J., Boutin, J. A., Harper, J. W., Brice, A., Guedin, D., Gautier, C. A., Corti, O. (2019) The PINK1 kinase-driven ubiquitin ligase Parkin promotes mitochondrial protein import through the presequence pathway in living cells. Scientific Reports. 9(1):11829

Gottlieb, C.D.*, Thompson, A.C.S.*, Ordureau, A., Harper, J.W., Kopito, R.R. (2019) Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes. J Biol Chem. 294 (45), 16511-16524

Najafov, A., Mookhtiar, A.K., Luu, H.S., Ordureau, A., Pan, H., Amin, P.P., Li, Y., Lu, Q., Yuan, J. (2019) TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. Molecular Cell. 75(3):457-468

An, H., Ordureau, A., Paulo, J.A., Shoemaker, C.J., Denic, V., Harper, J.W. (2019) TEX264 is an ER-resident ATG8-interacting protein critical for endoplasmic reticulum remodeling during nutrient stress. Molecular Cell. 74(5):891-908.

Heo, J.M., Ordureau, A., Swarup, S., Paulo, J.A., Shen, K., Sabatini, D.M., Harper, J.W. (2018) RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Science Advances. Nov 21;4(11)

Ordureau, A., Paulo, J.A., Zhang, W., Ahfeldt, T., Zhang, J., Cohn, E.F., Hou, Z., Heo, J.M., Rubin, L.L., Sidhu, S.S., Gygi, S.P., Harper, J.W. (2018) Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Molecular Cell. 70(2) 211-227

Harper, J.W., Ordureau, A., Heo, J.M. (2018) Building and decoding ubiquitin chains for mitophagy. Nat Rev Mol Cell Biol. 19(2):93-108

Mohideen, F., Paulo, J.A., Ordureau, A., Gygi, S.P., Harper, J.W. (2017) Quantitative Phospho-proteomic Analysis of TNFα/NFκB Signaling Reveals a Role for RIPK1 Phosphorylation in Suppressing Necrotic Cell Death. Mol Cell Proteomics. 16(7):1200-1216.

Wang, B., Jie, Z., Joo, D., Ordureau, A., Liu, P., Gan, W., Guo, J., Zhang, J., North, B.J., Dai, X., Cheng, X., Bian, X., Zhang, L., Harper, J.W., Sun, S.C., Wei, W. (2017) TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. Nature, 545(7654):365-369.

Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kołodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. (2017) G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol. 19(3):177-188.

Rose C.M.*, Isasa M.*, Ordureau A., Prado M.A., Beausoleil S.A., Jedrychowski M.P., Finley D.J., Harper J.W., Gygi S.P. (2016). Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes. Cell Systems 3(4):395-403

Brown, N. G.*, VanderLinden, R.*, Watson, E. R.*, Weissmann, F., Ordureau, A., Wu, K.-P., Zhang, W., Yu, S., Mercredi, P.Y., Harrison, J.S., Davidson, I.F., Qiao, R., Lu, Y., Dube, P., Brunner, M.R., Grace, C.R., Miller, D.J., Haselbach, D., Jarvis, M.A., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, S.S., Kuhlman, B., Kirschner, M.W., Harper, J.W., Peters, J.M., Stark, H., Schulman, B.A. (2016). Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell 165(6), 1440–1453.

Zhang, W.*, Wu, K.-P.*, Sartori, M.A., Kamadurai, H.B., Ordureau, A., Jiang, C., Mercredi, P.Y., Murchie, R., Hu, J., Persaud, A., Mukherjee, M., Li, N., Doye, A., Walker, J.R., Sheng, Y., Hao, Z., Li, Y., Brown, Y.K., Lemichez, E., Chen, J., Tong, Y., Harper, J.W., Moffat, J., Rotin, D., Schulman, B.A., and Sidhu, S.S (2016). System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Molecular Cell 62, 121–136.

Heo, J.H., Ordureau, A., Paulo, J.A., Rinehart, J., and Harper, J.W. (2015) The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Molecular Cell 60, 7–20.

Huttlin, E.L., Ting, L., Bruckner, R.J., Gebreab, F., Gygi, M.P., Szpyt, J., Tam, S., Zarraga, G., Colby, G., Baltier, K., Dong, R., Guarani, V., Vaites, L.P., Ordureau, A., Rad, R., Erickson, B.K., Wuhr, M., Chick, J., Zhai, B., Kolippakkam, D., Mintseris, J., Obar, R.A., Harris, T., Artavanis-Tsakonas, S., Sowa, M.E., De Camilli, P., Paulo, J.A., Harper, J.W., and Gygi, S.P. (2015). The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 162, 425-440.

Pickrell, A.M.*, Huang, C.H.*, Kennedy, S.R., Ordureau, A., Sideris, D.P., Hoekstra, J.G., Harper, J.W., and Youle, R.J. (2015). Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron 87, 371-381.

Ordureau, A., Munch, C., and Harper, J.W. (2015). Quantifying ubiquitin signaling. Molecular Cell 58, 660-676.

Ordureau, A., Heo, J.M., Duda, D.M., Paulo, J.A., Olszewski, J.L., Yanishevski, D., Rinehart, J., Schulman, B.A., and Harper, J.W. (2015). Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy. Proc Natl Acad Sci USA 112, 6637-6642.

Cirulli, E.T., Lasseigne, B.N., Petrovski, S., Sapp, P.C., Dion, P.A., Leblond, C.S., Couthouis, J., Lu, Y.F., Wang, Q., Krueger, B.J., Ren, Z., Keebler, J., Han, Y., Levy, S.E., Boone, B.E., Wimbish, J.R., Waite, L.L., Jones, A.L., Carulli, J.P., Day-Williams, A.G., Staropoli, J.F., Xin, W.W., Chesi, A., Raphael, A.R., McKenna-Yasek, D., Cady, J., Vianney de Jong, J.M., Kenna, K.P., Smith, B.N., Topp, S., Miller, J., Gkazi, A., Consortium, F.S., Al-Chalabi, A., van den Berg, L.H., Veldink, J., Silani, V., Ticozzi, N., Shaw, C.E., Baloh, R.H., Appel, S., Simpson, E., Lagier-Tourenne, C., Pulst, S.M., Gibson, S., Trojanowski, J.Q., Elman, L., McCluskey, L., Grossman, M., Shneider, N.A., Chung, W.K., Ravits, J.M., Glass, J.D., Sims, K.B., Van Deerlin, V.M., Maniatis, T., Hayes, S.D., Ordureau, A., Swarup, S., Landers, J., Baas, F., Allen, A.S., Bedlack, R.S., Harper, J.W., Rouleau, G.A., Brown, R., Harms, M.B., Cooper, G.M., Harris, T., Myers, R.M., and Goldstein, D.B. (2015). Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science 347, 1436-1441.

Li, N., Fassl, A., Chick, J., Inuzuka, H., Li, X., Mansour, M.R., Liu, L., Wang, H., King, B., Shaik, S., Gutierrez, A., Ordureau, A., Otto, T., Kreslavsky, T., Baitsch, L., Bury, L., Meyer, C.A., Ke, N., Mulry, K.A., Kluk, M.J., Roy, M., Kim, S., Zhang, X., Geng, Y., Zagozdzon, A., Jenkinson, S., Gale, R.E., Linch, D.C., Zhao, J.J., Mullighan, C.G., Harper, J.W., Aster, J.C., Aifantis, I., von Boehmer, H., Gygi, S.P., Wei, W., Look, A.T., and Sicinski, P. (2014). Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol 16, 1080-1091.

Ordureau, A., Sarraf, S.A., Duda, D.M., Heo, J.M., Jedrychowski, M.P., Sviderskiy, V.O., Olszewski, J.L., Koerber, J.T., Xie, T., Beausoleil, S.A., Wells, J.A., Gygi, S.P., Schulman, B.A., and Harper, J.W. (2014). Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Molecular Cell 56, 360-375.

Ordureau, A., and Harper, J.W. (2014). Cell biology: balancing act. Nature 510, 347-348.

Emmerich, C.H., Ordureau, A., Strickson, S., Arthur, J.S., Pedrioli, P.G., Komander, D., and Cohen, P. (2013). Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci USA 110, 15247-15252.

Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P.R., and Cohen, P. (2013). DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA. J Biol Chem 288, 24569-24580.

Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P.C., Patterson-Kane, J., Arthur, J.S., and Cohen, P. (2012). Pellino1 is required for interferon production by viral double-stranded RNA. J Biol Chem 287, 34825-34835.

Gleason, C.E., Ordureau, A., Gourlay, R., Arthur, J.S., and Cohen, P. (2011). Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon beta. J Biol Chem 286, 35663-35674.

Nanda, S.K., Venigalla, R.K., Ordureau, A., Patterson-Kane, J.C., Powell, D.W., Toth, R., Arthur, J.S., and Cohen, P. (2011). Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med 208, 1215-1228.

Nichols, R.J., Dzamko, N., Morrice, N.A., Campbell, D.G., Deak, M., Ordureau, A., Macartney, T., Tong, Y., Shen, J., Prescott, A.R., and Alessi, D.R. (2010). 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson’s disease-associated mutations and regulates cytoplasmic localization. Biochem J. 430, 393-404.

Ordureau, A.*, Smith, H.*, Windheim, M., Peggie, M., Carrick, E., Morrice, N., and Cohen, P. (2008). The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem J. 409, 43-52.

(*) Indicates equal contribution by authors.

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