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57. Raiff, A., Zhao, S., Bekturova, A., Zenge, C., Mazor, S., Chen, X., Ru, W., Makaros, Y., Ast, T., Ordureau, A., Xu, C., Koren, I. TOM20-driven E3 ligase recruitment regulates mitochondrial dynamics through PLD6. Nat Chem Biol. AOP
56. Pham, B.Q., Yi, S.A., Ordureau, A., An, H. (2025) mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase. Cell Report 44(1):115179
55. Zenge, C., Ordureau, A. (2024) Ubiquitin system mutations in neurological diseases. Trends Biochem. Sci. 49, 875–887
53. Sinha, N.K., McKenney, C., Yeow, Z.Y.*, Li, J.J.*, Nam, K.H.*, Yaron-Barir, T.M., Johnson, J.L., Huntsman, E.M., Cantley, L.C., Ordureau, A.†, Regot, S.†, Green, R.†. (2024) The ribotoxic stress response drives UV-mediated cell death. Cell, 187(14):3652-3670 (†Co-Corresponding Author)
52. Yi, S.A., Sepic, S., Schulman, B.A., Ordureau, A., An, H. (2024) mTORC1-CTLH E3 Ligase Regulates the Degradation of HMG-CoA Synthase 1 through the Pro/N-Degron Pathway. Mol Cell, 84(11):2166-2184
51. Nam, K.H. and Ordureau, A. (2024) How does the neuronal proteostasis network react to cellular cues? Biochem. Soc. Trans. 52(2), 581-592.
48. Paul, S., Sarraf, S.A., Nam, K.H., Zavar, L., DeFoor, N., Biswas, S.R., Fritsch, L.E., Yaron, T.M., Johnson, J.L., Huntsman, E.M., Cantley, L.C., Ordureau, A., Pickrell, A.M. (2024) NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. J Cell Biol. 223(2):e202303082.
42. Nam, KH., Ordureau, A. (2022) Quantitative proteome remodeling characterization of two human reference pluripotent stem cell lines during neurogenesis and cardiomyogenesis. Proteomics. Oct;22(19-20):e2100246
39. Antico, O.*, Ordureau, A.*, Stevens, M., Singh, F., Nirujogi, R.S., Gierlinski, M., Barini, E., Rickwood, M.L., Prescott, A., Toth, R., Ganley, I.G., Harper, J.W., Muqit, M.M.K. (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Science Advances. 7(46):eabj0722.
38. Ordureau, A.†, Kraus, F., Zhang, J., An, H., Park, S., Ahfeldt, T., Paulo, J.A., Harper, J.W.†. (2021) Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy. Molecular Cell. 81(24):5082-5098.e11.
37. Ordureau, A., Yu, Q., Bomgarden., R.D., Rogers, J.C., Harper, J.W., Gygi, S.P., Paulo, J.A. (2021) Super Heavy TMTpro Labeling Reagent: An Alternative and Higher-Charge-State-Amenable Stable-Isotope-Labeled TMTpro Variant. J Proteome Res. 7;20(5):3009-3013.
34. Sinha, N.K.*, Ordureau, A.*, Best, K.M.*, Saba, J.A., Zinshteyn, B., Sundaramoorthy, E., Fulzele, A., Garshott, D.M., Denk, T., Thoms, M., Paulo, J.A., Harper, J.W., Bennett, E.J., Beckmann, R., Green, R. (2020) EDF1 coordinates cellular responses to ribosome collisions. eLife 9, e58828.
33. An, H.*, Ordureau, A.*, Korner, M., Paulo, J.A., Harper, J.W. (2020) Systematic Quantitative Analysis of Ribosome Inventory During Nutrient Stress. Nature 583(7815), 303-309.
31. Ordureau, A., Paulo, J.A., Zhang, J., An, H., Swatek, K.N., Cannon, J.R., Wan, Q., Komander, D., Harper, J.W. (2020) Global landscape and dynamics of Parkin and USP30-dependent ubiquitylomes in iNeurons during mitophagic signaling. Molecular Cell. 77(5):1124-1142.
26. An, H., Ordureau, A., Paulo, J.A., Shoemaker, C.J., Denic, V., Harper, J.W. (2019) TEX264 is an ER-resident ATG8-interacting protein critical for endoplasmic reticulum remodeling during nutrient stress. Molecular Cell. 74(5):891-908.
24. Ordureau, A., Paulo, J.A., Zhang, W., Ahfeldt, T., Zhang, J., Cohn, E.F., Hou, Z., Heo, J.M., Rubin, L.L., Sidhu, S.S., Gygi, S.P., Harper, J.W. (2018) Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Molecular Cell. 70(2) 211-227.
23. Harper, J.W., Ordureau, A., Heo, J.M. (2018) Building and decoding ubiquitin chains for mitophagy. Nat Rev Mol Cell Biol. 19(2):93-108.
16. Heo, J.H., Ordureau, A., Paulo, J.A., Rinehart, J., and Harper, J.W. (2015) The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Molecular Cell 60, 7–20.
13. Ordureau, A., Munch, C., and Harper, J.W. (2015). Quantifying ubiquitin signaling. Molecular Cell 58, 660-676.
12. Ordureau, A., Heo, J.M., Duda, D.M., Paulo, J.A., Olszewski, J.L., Yanishevski, D., Rinehart, J., Schulman, B.A., and Harper, J.W. (2015). Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy. Proc Natl Acad Sci USA 112, 6637-6642.
9. Ordureau, A., Sarraf, S.A., Duda, D.M., Heo, J.M., Jedrychowski, M.P., Sviderskiy, V.O., Olszewski, J.L., Koerber, J.T., Xie, T., Beausoleil, S.A., Wells, J.A., Gygi, S.P., Schulman, B.A., and Harper, J.W. (2014). Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Molecular Cell 56, 360-375.
7. Emmerich, C.H., Ordureau, A., Strickson, S., Arthur, J.S., Pedrioli, P.G., Komander, D., and Cohen, P. (2013). Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci USA 110, 15247-15252.
6. Ordureau, A., Enesa, K., Nanda, S., Le Francois, B., Peggie, M., Prescott, A., Albert, P.R., and Cohen, P. (2013). DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA. J Biol Chem 288, 24569-24580.
5. Enesa, K., Ordureau, A., Smith, H., Barford, D., Cheung, P.C., Patterson-Kane, J., Arthur, J.S., and Cohen, P. (2012). Pellino1 is required for interferon production by viral double-stranded RNA. J Biol Chem 287, 34825-34835.
4. Gleason, C.E., Ordureau, A., Gourlay, R., Arthur, J.S., and Cohen, P. (2011). Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon beta. J Biol Chem 286, 35663-35674.
1. Ordureau, A.*, Smith, H.*, Windheim, M., Peggie, M., Carrick, E., Morrice, N., and Cohen, P. (2008). The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem J. 409, 43-52.